IP Library › Granted Patent US 8,183,350
Granted Patent B2
US 8,183,350 · App. 10/513,573 · Granted May 22, 2012

Compositions and methods for promoting neuronal outgrowth

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Quick Facts
Patent No.
US 8,183,350
App. No.
10/513,573
Granted
May 22, 2012
Kind
B2
Abstract

Neural outgrowth in the central nervous system is achieved by administering chondroitinase AC and/or chondroitinase B to degrade chondroitin sulfate proteoglycans that inhibit or contribute to the inhibition of nervous tissue regeneration.

Claims (7)

1. A method of promoting neurite outgrowth of central nervous system neural cells in a mammal comprising contacting injured central nervous system neural cells directly at the site of a central nervous system injury with a composition comprising a compound selected from the group consisting of chondroitinase AC and chondroitinase B; whereby neurite outgrowth occurs from said central nervous system neural cells.

2. A method as in claim 1 , wherein the compound is chondroitinase AC.

3. A method as in claim 1 , wherein the compound is chondroitinase B.

4. A method as in claim 1 , wherein the composition further comprises a pharmaceutically acceptable carrier.

5. A method as in claim 1 , wherein the composition further comprises a stabilizer.

6. The method of claim 1 , wherein the site of the central nervous system injury is the spinal cord.

7. The method of claim 1 , wherein the mammal is a human.

Assignments (3)
RELEASE OF SECURITY INTEREST Recorded May 31, 2017
From: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
To: NEURONEX, INC.; CIVITAS THERAPEUTICS, INC.; ACORDA THERAPEUTICS, INC.
Reel/Frame 042643/0878 →
SECURITY INTEREST Recorded Jun 10, 2016
From: ACORDA THERAPEUTICS, INC.; CIVITAS THERAPEUTICS, INC.; NEURONEX, INC.
To: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 038950/0436 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 7, 2006
From: GRUSKIN, ELLIOTT A.; IACI, JENNIFER F.; VECCHIONE, ANDREA M.; KASPERBAUER, SARAH; ROY, GARGI
To: ACORDA THERAPEUTICS, INC.
Reel/Frame 017267/0539 →