Self-administered contraceptive injection of oily solution
The subject invention provides a pharmaceutical formulation in the form of an oily solution for injection to a subject comprising a contraceptively and/or therapeutically effective amount of a long-acting progestogen and a contraceptively and/or therapeutically effective amount of a long-acting androgen dissolved in a pharmaceutically acceptable oily medium wherein the injection is administered by the subject itself with a needle-less device, a mini-needle device or a pre-filled subcutaneous syringe.
1 - 72 . (canceled)
73 . An oily solution for injection to a subject comprising a 50-400 mg/ml of a long-acting progestogen and 25-200 mg/ml of a long-acting androgen dissolved in a pharmaceutically acceptable oily medium.
74 . A solution according to claim 1 wherein the long acting progestogen is an ester with a fatty chain length of C7 to C15.
75 . A solution according to claim 2 wherein the long acting progestogen is an ester or a progestogen selected from the group consisting of ethisterone, norethisterone, dimethisterone, norethynodrel, norgestrienone, lynestrenol, ethynodiol, norgestrel, levo-norgestrel, desogestrel, gestodene, allylestrenol, etonogestrel and dienogest.
76 . A solution according to claim 3 wherein the ester of progestogen is etonogestrel undecanoate.
77 . A solution according to claim 1 wherein the long-acting androgen is an ester with a fatty chain length of C6 to C12.
78 . A solution according to claim 5 wherein the long-acting androgen is an ester of testosterone or an ester of 7-alpha-methyl-19-nortestosterone.
79 . A solution according to claim 6 wherein the ester of the androgen is 7-alpha-methyl-19-nortestostetone undecanoate.
80 . A solution according to claim 1 wherein the oily medium is arachis oil or ethyl undecanoate.
81 . A needle-less device, a mini-needle device or a pre-filled subcutaneous syringe, each for injection administration by the subject himself, comprising less than 1 millilitre of the solution according to claim 1 .