Preventives remedies for bone and joint diseases
A compound or its salt that inhibits the activity of a protein having an amino acid sequence which is the same or substantially the same amino acid sequence represented by SEQ ID NO: 1, an antibody to the above protein, an antisense nucleotide having a base sequence which is complementary or substantially complementary to the base sequence of a DNA encoding the above protein or its peptide fragment, etc. are usable as prophylactic/therapeutic agents for bone and joint diseases.
1 . A prophylactic/therapeutic agent for bone and joint diseases, comprising a compound or its salt that inhibits the activity of a protein having an amino acid sequence which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, its partial peptide, or a salt thereof.
2 . A prophylactic/therapeutic agent for bone and joint diseases, comprising a compound or its salt that inhibits the expression of a gene for a protein having an amino acid sequence which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, its partial peptide, or a salt thereof.
3 . A prophylactic/therapeutic agent for bone and joint diseases, comprising an antisense nucleotide having a base sequence which is complementary or substantially complementary to the base sequence of a polynucleotide encoding a protein having an amino acid sequence which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, or its partial peptide, or a part of the base sequence.
4 . A prophylactic/therapeutic agent for bone and joint diseases, comprising an antibody to a protein having an amino acid sequence which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, its partial peptide, or a salt thereof.
5 . The prophylactic/therapeutic agent according to claim 1 wherein the bone and joint diseases are chondrodysplasia, bone dysplasia, osteoporosis, osteoarthritis, chronic articular rheumatism, arthritis, synovitis, metabolic arthropathy or sports-related joint disorders.
6 . A diagnostic agent for bone and joint diseases, comprising an antibody to a protein having an amino acid sequence which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, its partial peptide, or a salt thereof.
7 . A diagnostic agent for bone and joint diseases, comprising a polynucleotide encoding a protein having an amino acid sequence which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, or its partial peptide.
8 . The diagnostic agent according to claim 6 , wherein the bone and joint diseases are chondrodysplasia, bone dysplasia, osteoporosis, osteoarthritis, chronic articular rheumatism, arthritis, synovitis, metabolic arthropathy or sports-related joint disorders.
9 . A prophylactic/therapeutic agent for bone and joint diseases, comprising a compound or its salt having an action of inhibiting a sulfatase activity.
10 . A prophylactic/therapeutic agent for bone and joint diseases, comprising a compound or its salt having an action of inhibiting the expression of a sulfatase.
11 . A method of screening a prophylactic/therapeutic agent for bone and joint diseases, which comprises using a protein having an amino acid sequence which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, its partial peptide, or a salt thereof.
12 . A kit for screening a prophylactic/therapeutic agent for bone and joint diseases, comprising a protein having an amino acid sequence which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, its partial peptide, or a salt thereof.
13 . A method of screening a prophylactic/therapeutic agent for bone and joint diseases, which comprises using a polynucleotide encoding a protein having an amino acid sequence which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, or its partial peptide.
14 . A kit for screening a prophylactic/therapeutic agent for bone and joint diseases, comprising a polynucleotide encoding a protein having an amino acid sequence which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, or its partial peptide.
15 . (canceled)
16 . A method of preventing/treating bone and joint diseases, which comprises administering to a mammal an effective dose of a compound or its salt that inhibits the activity of a protein having an amino acid sequence which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, its partial peptide, or a salt thereof, or an effective dose of a compound or its salt that inhibits the expression of a gene for the protein.
17 . A method of preventing/treating bone and joint diseases, which comprises inhibiting the activity of a protein having an amino acid sequence which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, its partial peptide, or a salt thereof, or inhibiting the expression of a gene for the protein.
18 . Use of a compound or its salt that inhibits the activity of a protein having an amino acid sequence which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, its partial peptide, or a salt thereof, or a compound or its salt that inhibits the expression of a gene for the protein, to manufacture a prophylactic/therapeutic agent for bone and joint diseases.