Therapeutic agent for brain hemorrhage
It was found that an AMPA receptor antagonist zonampanel or a salt or the like thereof has an effect to improve cerebral hemorrhage and neurological symptoms accompanied by cerebral hemorrhage and therefore is useful as an agent for treating cerebral hemorrhage.
1 . An agent for treating cerebral hemorrhage, which comprises [7-(1H-imidazol-1-yl)-6-nitro-2,3-dioxo-3,4-dihydroquinoxalin-1(2H)-yl]acetic acid or a salt or a hydrate thereof as an active ingredient.
2 . An agent for improving neurological symptoms accompanied by cerebral hemorrhage, which comprises [7-(1H-imidazol-1-yl)-6-nitro-2,3-dioxo-3,4-dihydroquinoxalin-1(2H)-yl]acetic acid or a salt or a hydrate thereof as an active ingredient.
3 . Use of [7-(1H-imidazol-1-yl)-6-nitro-2,3-dioxo-3,4-dihydroquinoxalin-1(2H)-yl]acetic acid or a salt or a hydrate thereof for manufacturing a medicament for treating cerebral hemorrhage which comprises a therapeutically effective amount of the same as an active ingredient.
4 . Use of [7-(1H-imidazol-1-yl)-6-nitro-2,3-dioxo-3,4-dihydroquinoxalin-1(2H)-yl]acetic acid or a salt or hydrate thereof for manufacturing a medicament for improving neurological symptoms accompanied by cerebral hemorrhage which comprises a therapeutically effective amount of the same as an active ingredient.
5 . A method for treating cerebral hemorrhage, which comprises administering a composition comprising a therapeutically effective amount of [7-(1H-imidazol-1-yl)-6-nitro-2,3-dioxo-3,4-dihydroquinoxalin-1(2H)-yl]acetic acid or a salt or a hydrate thereof and a pharmaceutically acceptable carrier to a patient.
6 . A method for improving neurological symptoms accompanied by cerebral hemorrhage, which comprises administering a composition comprising a therapeutically effective amount of [7-(1H-imidazol-1-yl)-6-nitro-2,3-dioxo-3,4-dihydroquinoxalin-1(2H)-yl]acetic acid or a salt or a hydrate thereof and a pharmaceutically acceptable carrier to a patient.