T cell receptor CDR3 sequences associated with multiple sclerosis and compositions comprising same
View Patent ↗The present invention relates generally to the field of treating and monitoring multiple sclerosis by utilizing T-cell receptors peptides. In particular, nucleic acids and peptide sequences of T-cell receptors found in a population of MS patients are provided, along with compositions comprising such TCR peptides for use in, e.g., vaccines.
1. A vaccine comprising a first peptide, wherein the first peptide comprises the sequence of SEQ ID NO:4, and optionally a pharmaceutically acceptable carrier.
2. The vaccine of claim 1 , wherein the peptide consists of the sequence of SEQ ID NO:4.
3. A peptide comprising the sequence of SEQ ID NO:4.
4. The vaccine of claim 1 further comprising a second peptide, wherein the sequence of the second peptide comprises the sequence of SEQ ID NO:5.
5. The vaccine of claim 1 further comprising a second peptide, wherein the sequence of the second peptide comprises the sequence of SEQ ID NO:6.
6. The vaccine of claim 1 further comprising a second peptide and a third peptide, wherein the sequence of the second peptide comprises the sequence of SEQ ID NO:5 and wherein the sequence of the third peptide comprises the sequence of SEQ ID NO:6.