Condensed heterocyclic pyrazole derivatives as kinase inhibitors

1. A bicyclo-pyrazole compound of formula (I):

wherein

X is NR′, O, S, SO or SO 2 ;

each of R and R 1 , being the same or different, is independently a hydrogen atom or an optionally substituted group selected from R′, —COR′, —COOR′, —CONHR′, —CONR′R′, —SO 2 R′, —SO 2 NHR′ or —SO 2 NR′R″; wherein each of R′ and R″, being the same or different, is independently selected from hydrogen or an optionally further substituted straight or branched C 1 -C 6 alkyl, aryl or aryl-C 1 -C 6 alkyl group;

R 2 is an optionally substituted group selected from R′, —CH 2 OR′ and OR′, wherein R′ is as above defined; and the pharmaceutically acceptable salts thereof with the proviso that such compound is not 4-phenyl-5-(phenylsulfonyl)-2H-thieno[2,3-c]pyrazol-3-amine or 5-phenyl-1H-furo[2,3-c]pyrazol-3-amine.

2. A compound, according to claim 1 , wherein X is S or O; R is —CONHR′; R 1 is —COR′, —CONHR′, —CONR′R″, —SO 2 NHR′ or —SO 2 NR′R″, wherein each of R′ and R″, being the same or different, is selected from hydrogen or an optionally substituted straight or branched C 1 -C 6 alkyl, aryl or aryl-C 1 -C 6 alkyl group; R 2 is hydrogen; or a the pharmaceutically acceptable salt thereof.

3. A compound, according to claim 1 , wherein X is S; R is —CONHR′; R 1 is —CONHR′ or —CONR′R″, wherein each of R′ and R″, being the same or different, is selected from hydrogen or an optionally substituted straight or branched C 1 -C 6 alkyl, aryl or aryl-C 1 -C 6 alkyl group; R 2 is hydrogen; or a pharmaceutically acceptable salt thereof.

4. A compound of formula (I) or a pharmaceutically acceptable salt, according to claim 1 , comprising:

1. N-benzyl-3-[(4-fluorobenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

2. N-ethyl-3-{[4-(4-ethylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

3. 3-{[4-(4-ethylpiperazin-1-yl)benzoyl]amino}-N-isopropyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

4. N-benzyl-3-{[4-(4-ethylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

5. N-{5-[(4-methylpiperazin-1-yl)carbonyl]-1H-thieno[2,3-c]pyrazol-3-yl}benzamide;

6. N-[5-(morpholin-4-ylcarbonyl)-1H-thieno[2,3-c]pyrazol-3-yl]benzamide;

7. 3-(benzoylamino)-N-(2-morpholin-4-ylethyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

8. 3-(benzoylamino)-N-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

9. 3-(benzoylamino)-N-(2-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

10. 3-(benzoylamino)-N-(4-cyanophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

11. 3-(benzoylamino)-N-(4-fluorophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

12. 3-(benzoylamino)-N-(4-chlorophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

13. 3-(benzoylamino)-N-(4-methoxyphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

14. 3-(benzoylamino)-N-(4-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

15. 3-(benzoylamino)-N-(tert-butyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

16. 3-(benzoylamino)-N-isopropyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

17. 3-(benzoylamino)-N-ethyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

18. 2-fluoro-N-{5-[(4-methylpiperazin-1-yl)carbonyl]-1H-thieno[2,3-c]pyrazol-3-yl}benzamide;

19. 2-fluoro-N-[5-(morpholin-4-ylcarbonyl)-1H-thieno[2,3-c]pyrazol-3-yl]benzamide;

20. 3-[(2-fluorobenzoyl)amino]-N-(2-morpholin-4-ylethyl)-1H -thieno[2,3-c]pyrazole-5-carboxamide;

21. 3-[(2-fluorobenzoyl)amino]-N-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

22. 3[(2-fluorobenzoyl)amino]-N-(2-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

23. N-(4-cyanophenyl)-3-[(2-fluorobenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

24. 3-[(2-fluorobenzoyl)amino]-N-(4-fluorophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

25. N-(4-chlorophenyl)-3-[(2-fluorobenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

26. 3-[(2-fluorobenzoyl)amino]-N-(4-methoxyphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

27. 3-[(2-fluorobenzoyl)amino]-N-(4-methylpheny)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

28. N-(tert-butyl)-3-[(2-fluorobenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

29. 3-[(2-fluorobenzoyl)amino]-N-isopropyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

30. N-ethyl-3-[(2-fluorobenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

31. 2-chloro-N-{5-[(4-methylpiperazin-1-yl)carbonyl]-1H-thieno[2,3-c]pyrazol-3-yl}benzamide;

32. 2-chloro-N-[5(morpholin-4-ylcarbonyl)-1H-thieno[2,3-c]pyrazol-3-yl]benzamide;

33. 3-[(2-chlorobenzoyl)amino]-N-(2-morpholin-4-ylethyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

34. 3-[(2-chlorobenzoyl)amino]-N-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

35. 3-[(2-chlorobenzoyl)amino]-N-(2-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

36. 3-[(2-chlorobenzoyl)amino]-N-(4-cyanophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

37. 3-[(2-chlorobenzoyl)amino]-N-(4-fluorophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

38. 3-[(2-chlorobenzoyl)amino]-N-(4-chlorophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

39. 3-[(2-chlorobenzoyl)amino]-N-(4-methoxyphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

40. 3-[(2-chlorobenzoyl)amino]-N-(4-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

41. N-(tert-butyl)-3-[(2-chlorobenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide; 42. 3-[(2-chlorobenzoyl)amino]-N-isopropyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

43. 3-[(2-chlorobenzoyl)amino]-N-ethyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

44. 2-methoxy-N-{5-[(4-methylpiperazin-1-yl)carbonyl]-1H-thieno[2,3-c]pyrazol-3-yl}benzamide;

45. 2-methoxy-N-[5-(morpholin-4-ylcarbonyl)-1H-thieno[2,3-c]pyrazol-3-yl]benzamide;

46. 3-[(2-methoxybenzoyl)amino]-N-(2-morpholin-4-ylethyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

47. 3-[(2-methoxybenzoyl)amino]-N-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

48. 3-[(2-methoxybenzoyl)amino]-N-(2-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

49. N-(4-cyanophenyl)-3-[(2-methoxybenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

50. N-(4-fluorophenyl)-3-[(2-methoxybenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

51. N-(4-chlorophenyl)-3-[(2-methoxybenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

52. 3-[(2-methoxybenzoyl)amino]-N-(4-methoxyphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

53. 3-[(2-methoxybenzoyl)amino]-N-(4-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

54. N-(tert-butyl)-3-[(2-methoxybenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

55. N-isopropyl-3-[(2-methoxybenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

56. N-ethyl-3-[(2-methoxybenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

57. 2-methyl-N-{5-[(4-methylpiperazin-1-yl)carbonyl]-1H-thieno[2,3-c]pyrazol-3- yl}benzamide;

58. 2-methyl-N-[5-(morpholin-4-ylcarbonyl)-1H-thieno[2,3-c]pyrazol-3-yl]benzamide;

59. 3-[(2-methylbenzoyl)amino]-N-(2-morpholin-4-ylethyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

60. 3-[(2-methylbenzoyl)amino]-N-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

61. 3-[(2-methylbenzoyl)amino]-N-(2-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

62. N-(4-cyanophenyl)-3-[(2-methylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

63. N-(4-fluorophenyl)-3-[(2-methylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

64. N-(4-chlorophenyl)-3-[(2-methylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

65. N-(4-methoxyphenyl)-3-[(2-methylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

66. 3-[(2-methylbenzoyl)amino]-N-(4-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

67. N-(tert-butyl)-3-[(2-methylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

68. N-isopropyl-3-[(2-methylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

69. N-ethyl-3-[(2-methylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

70. 3-methyl-N-{5-[(4-methylpiperazin-1-yl)carbonyl]1H-thieno[2,3-c]pyrazol-3-yl}benzamide;

71. 3-methyl-N-[5-(morpholin-4-ylcarbonyl)-1H-thieno[2,3-c]pyrazol-3-yl]benzamide;

72. 3-[(3-methylbenzoyl)amino]-N-(2-morpholin-4-ylethyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

73. 3-[(3-methylbenzoyl)amino]-N-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

74. 3-[(3-methylbenzoyl)amino]-N-(2-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

75. N-(4-cyanophenyl)-3-[(3-methylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

76. N-(4-fluorophenyl)-3-[(3-methylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

77. N-(4-chlorophenyl)-3-[(3-methylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

78. N-(4-methoxyphenyl)-3-[(3-methylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

79. 3-[(3-methylbenzoyl)amino]-N-(4-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

80. N-(tert-butyl)-3-[(3-methylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

81. N-isopropyl-3-[(3-methylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

82. N-ethyl-3-[(3-methylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

83. 4-fluoro-N-{5-[(4-methylpiperazin-1-yl)carbonyl]-1H-thieno[2,3-c]pyrazol-3-yl}benzamide;

84. 4-fluoro-N-[5-(morpholin-4-ylcarbonyl)-1H-thieno[2,3-c]pyrazol-3-yl]benzamide;

85. 3-[(4-fluorobenzoyl)amino]-N-(2-morpholin-4-ylethyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

86. 3-[(4-fluorobenzoyl)amino]-N-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

87. 3-[(4-fluorobenzoyl)amino]-N-(2-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

88. N-(4-cyanophenyl)-3-[(4-fluorobenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

89. 3-[(4-fluorobenzoyl)amino]-N-(4-fluorophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

90. N-(4-chlorophenyl)-3-[(4-fluorobenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

91. 3-[(4-fluorobenzoyl)amino]-N-(4-methoxyphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

92. 3-[(4-fluorobenzoyl)amino]-N-(4-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

93. N-(tert-butyl)-3-[(4-fluorobenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

94. 3-[(4-fluorobenzoyl)amino]-N-isopropyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

95. N-ethyl-3-[(4-fluorobenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

96. 4-chloro-N-{5-[(4-methylpiperazin-1-yl)carbonyl]-1H-thieno[2,3-c]pyrazol-3-yl}benzamide;

97. 4-chloro-N-[5-(morpholin-4-ylcarbonyl)-1H-thieno[2,3-c]pyrazol-3-yl]benzamide;

98. 3-[(4-chlorobenzoyl)amino]-N-(2-morpholin-4-ylethyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

99. 3-[(4-chlorobenzoyl)amino]-N-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

100. 3-[(4-chlorobenzoyl)amino]-N-(2-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

101. 3-[(4-chlorobenzoyl)amino]-N-(4-cyanophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

102. 3-[(4-chlorobenzoyl)amino]-N-(4-fluorophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

103. 3-[(4-chlorobenzoyl)amino]-N-(4-chlorophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

104. 3-[(4-chlorobenzoyl)amino]-N-(4-methoxyphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

105. 3-[(4-chlorobenzoyl)amino]-N-(4-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

106. N-(tert-butyl)-3-[(4-chlorobenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

107. 3-[(4-chlorobenzoyl)amino]-N-isopropyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

108. 3-[(4-chlorobenzoyl)amino]-N-ethyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

109. 4-methoxy-N-{5-[(4-methylpiperazin-1-yl)carbonyl]-1H-thieno[2,3-c]pyrazol-3-yl}benzamide;

110. 4-methoxy-N-[5-(morpholin-4-ylcarbonyl)-1H-thieno[2,3-c]pyrazol-3-yl]benzamide;

111. 3-[(4-methoxybenzoyl)amino]-N-(2-morpholin-4-ylethyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

112. 3-[(4-methoxybenzoyl)amino]-N-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

113. 3-[(4-methoxybenzoyl)amino]-N-(2-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

114. N-(4-cyanophenyl)-3-[(4-methoxybenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

115. N-(4-fluorophenyl)-3-[(4-methoxybenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

116. N-(4-chlorophenyl)-3-[(4-methoxybenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

117. 3-[(4-methoxybenzoyl)amino]-N-(4-methoxyphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

118. 3-[(4-methoxybenzoyl)amino]-N-(4-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

119. N-(tert-butyl)-3-[(4-methoxybenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

120. N-isopropyl-3-[(4-methoxybenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

121. N-ethyl-3-[(4-methoxybenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

122. 4-tert-butyl-N-{5-[(4-methylpiperazin-1-yl)carbonyl]-1H-thieno[2,3-c]pyrazol-3-yl}benzamide;

123. 4-tert-butyl-N-[5-(morpholin-4-ylcarbonyl)-1H-thieno[2,3-c]pyrazol-3-yl]benzamide;

124. 3-[(4-tert-butylbenzoyl)amino]-N-(2-morpholin-4-ylethyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

125. 3-[(4-tert-butylbenzoyl)amino]-N-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

126. 3-[(4-tert-butylbenzoyl)amino]-N-(2-methylphenyl)-1H-thieno[2,3-C]pyrazole-5-carboxamide;

127. 3-[(4-tert-butylbenzoyl)amino]-N-(4-cyanophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

128. 3-[(4-tert-butylbenzoyl)amino]-N-(4-fluorophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

129. 3-[(4-tert-butylbenzoyl)amino]-N-(4-chlorophenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

130. 3-[(4-tert-butylbenzoyl)amino]-N-(4-methoxyphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

131. 3-[(4-tert-butylbenzoyl)amino]-N-(4-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

132. N-(tert-butyl)-3-[(4-tert-butylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

133. 3-[(4-tert-butylbenzoyl)amino]-N-isopropyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

134. 3-[(4-tert-butylbenzoyl)amino]-N-ethyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

135. 4-methyl-N-{5-[(4-methylpiperazin-1-yl)carbonyl]-1H-thieno[2,3-c]pyrazol-3-yl}benzamide;

136. 4-methyl-N-[5-(morpholin-4-ylcarbonyl)-1H-thieno[2,3-c]pyrazol-3-yl]benzamide;

137. 3-[(4-methylbenzoyl)amino]-N-(2-morpholin-4-ylethyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

138. 3-[(4-methylbenzoyl)amino]-N-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;

139. 3-[(4-methylbenzoyl)amino]-N-(2-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

140. N-(4-cyanophenyl)-3-[(4-methylbenzoyl)amino]-1H-thieno[21,3-c]pyrazole-5-carboxamide;

141. N-(4-fluorophenyl)-3-[(4-methylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

142. N-(4-chlorophenyl)-3-[(4-methybenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

143. N-(4-methoxyphenyl)-3-[(4-methylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

144. 3-[(4-methylbenzoyl)amino]-N-(4-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

145. N-(tert-butyl)-3-[(4-methylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

146. N-isopropyl-3-[(4-methylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

147. N-ethyl-3-[(4-methylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

148. 3-[(3-fluorobenzoyl)amino]-N-(4-morpholin-4-ylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

149. N-(2-cyanophenyl)-3-[(3-fluorobenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

150. 3-[(3-fluorobenzoyl)amino]-N-(24fluorophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

151. N-(2-chlorophenyl)-3-[(3-fluorobenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

152. N-(2,6-dichlorophenyl)-3-[(3-fluorobenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

153. 3-[(3-fluorobenzoyl)amino]-N-(2-methoxyphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

154. N-(2,6-diethylphenyl)-3-[(3-fluorobenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

155. N-(3-cyanophenyl)-3-[(3-fluorobenzoyl)amino]-1H-thieno [2,3-c]pyrazole-5-carboxamide;

156. 3-[(3-fluorobenzoyl)amino]-N-(3-fluorophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

157. N-(3-chlorophenyl)-3-[(3-fluorobenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

158. 3-[(3-fluorobenzoyl)amino]-N-(3-methoxyphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

159. 3-[(3-fluorobenzoyl)amino]-N-(3-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

160. 3-[(3-fluorobenzoyl)amino]-N-[4-(4-methylpiperazin-1-yl)phenyl]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

161. 3-[(3-chlorobenzoyl)amino]-N-(4-morpholin-4-ylphenyl)1H-thieno[2,3-c]pyrazole-5-carboxamide;

162. 3-[(3-chlorobenzoyl)amino]-N-(2-cyanophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

163. 3-[(3-chlorobenzoyl)amino]-N-(2-fluorophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

164. 3-[(3-chlorobenzoyl)amino]-N-(2-chlorophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

165. 3-[(3-chlorobenzoyl)amino]-N-(2,6-dichlorophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

166. 3-[(3-chlorobenzoyl)amino]-N-(2-ethoxyphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

167. 3-[(3-chlorobenzoyl)amino]-N-(2,6-diethylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

168. 3-[(3-chlorobenzoyl)amino]-N-(3-cyanophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

169. 3-[(3-chlorobenzoyl)amino]-N-(3-fluorophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

170. 3-[(3-chlorobenzoyl)amino]-N-(3-chlorophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

171. 3-[(3-chlorobenzoyl)amino]-N-(3-methoxyphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

172. 3-[(3-chlorobenzoyl)amino]-N-(3-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

173. 3-[(3-chlorobenzoyl)amino]-N-[4-(4-methylpiperazin-1yl)phenyl]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

174. 3-[(3-methoxybenzoyl)amino]-N-(4-morpholin-4-ylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

175. N-(2-cyanophenyl)-3-[(3-methoxybenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

176. N-(2-fluorophenyl)-3-[(3-methoxybenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

177. N-(2-chlorophenyl)-3-[(3-methoxybenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

178. N-(2,6-dichlorophenyl)-3-[(3-methoxybenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

179. 3-[(3-methoxybenzoyl)amino]-N-(2-methoxyphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

180. N-(2,6-diethylphenyl)-3-[(3-methoxybenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

181. N-(3-cyanophenyl)-3-[(3-methoxybenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

182. N-(3-fluorophenyl)-3-[(3-methoxybenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

183. N-(3-chlorophenyl)-3-[(3-methoxybenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

184. 3-[(3-methoxybenzoyl)amino]-N-(3-methoxyphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

185. 3-[(3-methoxybenzoyl)amino]-N-(3-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

186. 3-[(3-methoxybenzoyl)amino]-N-[4-(4-methylpiperazin-1-yl)phenyl]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

187. N-(4-morpholin-4-ylphenyl)-3-[(phenylacetyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

188. N-(2-cyanophenyl)-3-[(phenylacetyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

189. N-(2-fluorophenyl)-3-[(phenylacetyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

190. N-(2-chlorophenyl)-3-[(phenylacetyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

191. N-(2,6-dichlorophenyl)-3-[(phenylacetyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

192. N-(2-methoxyphenyl)-3-[(phenylacetyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

193. N-(2,6-diethylphenyl)-3-[(phenylacetyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

194. N-(3-cyanophenyl)-3-[(phenylacetyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

195. N-(3-fluorophenyl)-3-[(phenylacetyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

196. N-(3-chlorophenyl)-3-[(phenylacetyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

197. N-(3-methoxyphenyl)-3-[(phenylacetyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

198. N-(3-methylphenyl)-3-[(phenylacetyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

199. N-[4-(4-methylpiperazin-1-yl)phenyl]-3-[(phenylacetyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

200. 3-{[(2-fluorophenyl)acetyl]amino}-N-(4-morpholin-4-ylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

201. N-(2-cyanophenyl)-3-{[(2-fluorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

202. N-(2-fluorophenyl)-3-{[(2-fluorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

203. N-(2-chlorophenyl)-3- {[(2-fluorophenyl)acetyl]amino}-1H-1-thieno[2,3-c]pyrazole-5-carboxamide;

204. N-(2,6-dichlorophenyl)-3-{[(2-fluorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

205. 3-{[(2-fluorophenyl)acetyl]amino}-N-(2-methoxyphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

206. N-(2,6-diethylphenyl)-3-{[(2-fluorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

207. N-(3-cyanophenyl)-3-{[(2-fluorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

208. N-(3-fluorophenyl)-3-{[(2-fluorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

209. N-(3-chlorophenyl)-3-{[(2-fluorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

210. 3-{[(2-fluorophenyl)acetyl]amino}-N-(3-methoxyphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

211. 3-{[(2-fluorophenyl)acetyl]amino}-N-(3-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

212. 3-{[(2-fluorophenyl)acetyl]amino}-N-[4-(4-methylpiperazin-1-yl)phenyl]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

213. 3-{[(2-methylphenyl)acetyl]amino}-N-(4-morpholin-4-ylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

214. N-(2-cyanophenyl)-3-{[(2-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

215. N-(2-fluorophenyl)-3-{[(2-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

216. N-(2-chlorophenyl)-3-{[(2-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

217. N-(2,6-dichlorophenyl)-3-{[(2-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

218. N-(2-methoxyphenyl)-3-{[(2-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

219. N-(2,6-diethylphenyl)-3-{[(2-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

220. N-(3-cyanophenyl)-3-{[(2-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

221. N-(3-fluorophenyl)-3-{[(2-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

222. N-(3-chlorophenyl)-3-{[(2-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

223. N-(3-methoxyphenyl)-3-{[(2-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

224. N-(3-methylphenyl)-3-{[(2-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

225. 3-{[(2-methylphenyl)acetyl]amino}-N-[4-(4-methylpiperazin-1-yl)phenyl]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

226. 3-{[(4-fluorophenyl)acetyl]amino}-N-(4-morpholin-4-ylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

227. N-(2-cyanopbenyl)-3-{[(4-fluorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

228. N-(2-fluorophenyl)-3-{[(4-fluorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

229. N-(2-chlorophenyl)-3-{[(4-fluorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

230. N-(2,6-dichlorophenyl)-3-{[(4-fluorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

231. 3-{[(4-fluorophenyl)acetyl]amino}-N-(2-methoxyphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

232. N-(2,6-diethylphenyl)-3-{[(4-fluorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

233. N-(3-cyanophenyl)-3-{[(4-fluorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

234. N-(3-fluorophenyl)-3-{[(4-fluorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

235. N-(3-chlorophenyl)-3-{[(4-fluorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

236. 3-{[(4-fluorophenyl)acetyl]amino}-N-(3-methoxyphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

237. 3-{[(4-fluorophenyl)acetyl]amino}-N-(3-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

238. 3-{[(4-fluorophenyl)acetyl]amino}-N-[4-(4-methylpiperazin-1-yl)phenyl]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

239. 3-{[(4-chlorophenyl)acetyl]amino}-N-(4-morpholin-4-ylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

240. 3-{[(4-chlorophenyl)acetyl]amino}-N-(2-cyanophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

241. 3-{[(4-chlorophenyl)acetyl]amino}-N-(2-fluorophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

242. N-(2-chlorophenyl)-3-{[(4-chlorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

243. 3-{[(4-chlorophenyl)acetyl]amino}-N-(2,6-dichlorophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

244. 3-{[(4-chlorophenyl)acetyl]amino}-N-(2-methoxyphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

245. 3-{[(4-chlorophenyl)acetyl]amino}-N-(2,6-diethylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

246. 3-{[(4-chlorophenyl)acetyl]amino}-N-(3-cyanophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

247. 3-{[(4-chlorophenyl)acetyl]amino}-N-(3-fluorophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

248. N-(3-chlorophenyl)-3-{[(4-chlorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

249. 3-{[(4-chlorophenyl)acetyl]amino}-N-(3-methoxyphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

250. 3-{[(4-chlorophenyl)acetyl]amino}-N-(3-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

251. 3-{[(4-chlorophenyl)acetyl]amino}-N-[4-(4-methylpiperazin-1-yl)phenyl]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

252. 3-{[(4-methoxyphenyl)acetyl]amino}-N-(4-morpholin-4-ylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

253. N-(2-cyanophenyl)-3-{[(4-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

254. N-(2-fluorophenyl)-3-{[(4-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

255. N-(2-chlorophenyl)-3-{[(4-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

256. N-(2,6-dichlorophenyl)-3-{[(4-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

257. N-(2-methoxyphenyl)-3-{[(4-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

258. N-(2,6-diethylphenyl)-3-{[(4-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

259. N-(3-cyanophenyl)-3-{[(4-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

260. N-(3-fluorophenyl)-3-{[(4-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

261. N-(3-chlorophenyl)-3-{[(4-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

262. N-(3-methoxyphenyl)-3-{[(4-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

263. 3-{[(4-methoxyphenyl)acetyl]amino}-N-(3-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

264. 3-{[(4-methoxyphenyl)acetyl]amino}-N-[4-(4-methylpiperazin-1-yl)phenyl]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

265. 3-{[(4-methylphenyl)acetyl]amino}-N-(4-morpholin-4-ylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

266. N-(2-cyanophenyl)-3-{[(4-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

267. N-(2-fluorophenyl)-3-{[(4-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

268. N-(2-chlorophenyl)-3-{[(4-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

269. N-(2,6-dichlorophenyl)-3-{[(4-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

270. N-(2-methoxyphenyl)-3-{[(4-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

271. N-(2,6-diethylphenyl)-3-{[(4-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

272. N-(3-cyanophenyl)-3-{[(4-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5 carboxamide;

273. N-(3-fluorophenyl)-3-{[(4-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

274. N-(3-chlorophenyl)-3-{[(4-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

275. N-(3-methoxyphenyl)-3-{[(4-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

276. N-(3-methylphenyl)-3-{[(4-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

277. 3-{[(4-methylphenyl)acetyl]amino}-N-[4-(4-methylpiperazin-1-yl)phenyl]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

278. 3-{[(4-tert-butylphenyl)acetyl]amino}-N-(4-morpholin-4-ylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

279. 3-{[(4-tert-butylphenyl)acetyl]amino}-N-(2-cyanophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

280. 3-{[(4-tert-butylphenyl)acetyl]amino}-N-(2-fluorophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

281. 3-{[(4-tert-butylphenyl)acetyl]amino}-N-(2-chlorophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

282. 3-{[(4-tert-butylphenyl)acetyl]amino}-N-(2,6-dichlorophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

283. 3-{[(4-tert-butylphenyl)acetyl]amino}-N-(2-methoxyphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

284. 3-{[(4-tert-butylphenyl)acetyl]amino}-N-(2,6-diethylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

285. 3-{[(4-tert-butylphenyl)acetyl]amino}-N-(3-cyanophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

286. 3-{[(4-tert-butylphenyl)acetyl]amino}-N-(3-fluorophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

287. 3-{[(4-tert-butylphenyl)acetyl]amino}-N-(3-chlorophenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

288. 3-{[(4-tert-butylphenyl)acetyl]amino}-N-(3-methoxyphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

289. 3-{[(4-tert-butylphenyl)acetyl]amino}-N-(3-methylphenyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

290. 3-{[(4-tert-butylphenyl)acetyl]amino}-N-[4-(4-methylpiperazin-1-yl)phenyl]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

291. N-benzyl-3-{[(2-chlorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

292. 3-{[(2-chlorophenyl)acetyl]amino}-N-(2-fluorobenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

293. N-(2-chlorobenzyl)-3-{[(2-chlorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

294. 3-{[(2-chlorophenyl)acetyl]amino}-N-(2-methoxybenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

295. 3-{[(2-chlorophenyl)acetyl]amino}-N-(2-methylbenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

296. 3-{[(2-chlorophenyl)acetyl]amino}-N-(3-fluorobenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

297. 3-{[(2-chlorophenyl)acetyl]amino}-N-(3-methoxybenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

298. 3-{[(2-chlorophenyl)acetyl]amino}-N-(3-methylbenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

299. 3-{[(2-chlorophenyl)acetyl]amino}-N-(4-fluorobenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

300. N-(4-chlorobenzyl)-3-{[(2-chlorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

301. 3-{[(2-chlorophenyl)acetyl]amino}-N-(4-methoxybenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

302. 3-{[(2-chlorophenyl)acetyl]amino}-N-(4-methylbenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

303. N-(3-chlorobenzyl)-3-{[(2-chlorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

304. N-benzyl-3-{[(2-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

305. N-(2-fluorobenzyl)-3-{[(2-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

306. N-(2-chlorobenzyl)-3-{[(2-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

307. N-(2-methoxybenzyl)-3-{[(2-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

308. 3-{[(2-methoxyphenyl)acetyl]amino}-N-(2-methylbenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

309. N-(3-fluorobenzyl)-3-{[(2-methoxyphenyl)acetyl]amino}1H-thieno[2,3-c]pyrazole-5-carboxamide;

310. N-(3-methoxybenzyl)-3-{[(2-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

311. 3-{[(2-methoxyphenyl)acetyl]amino}-N-(3-methylbenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

312. N-(4-fluorobenzyl)-3-{[(2-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

313. N-(4-chlorobenzyl)-3-{[(2-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

314. N-(4-methoxybenzyl)-3-{[(2-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

315. 3-{[(2-methoxyphenyl)acetyl]amino}-N-(4-methylbenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

316. N-(3-chlorobenzyl)-3-{[(2-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

317. N-benzyl-3-{[(3-fluorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

318. N-(2-fluorobenzyl)-3-{[(3-fluorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

319. N-(2-chlorobenzyl)-3-{[(3-fluorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

320. 3-{[(3-fluorophenyl)acetyl]amino}-N-(2-methoxybenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

321. 3-{[(3-fluorophenyl)acetyl]amino}-N-(2-methylbenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

322. N-(3-fluorobenzyl)-3-{[(3-fluorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

323. 3-{[(3-fluorophenyl)acetyl]amino}-N-(3-methoxybenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

324. 3-{[(3-fluorophenyl)acetyl]amino}-N-(3-methylbenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

325. N-(4-fluorobenzyl)-3-{[(3-fluorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

326. N-(4-chlorobenzyl)-3-{[(3-fluorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

327. 3-{[(3-fluorophenyl)acetyl]amino}-N-(4-methoxybenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

328. 3-{[(3-fluorophenyl)acetyl]amino}-N-(4-methylbenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

329. N-(3-chlorobenzyl)-3-{[(3-fluorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

330. N-benzyl-3-{[(3-chlorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

331. 3-{[(3-chlorophenyl)acetyl]amino}-N-(2-fluorobenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

332. N-(2-chlorobenzyl)-3-{[(3-chlorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

333. 3-{[(3-chlorophenyl)acetyl]amino}-N-(2-methoxybenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

334. 3-{[(3-chlorophenyl)acetyl]amino}-N-(2-methylbenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

335. 3-{[(3-chlorophenyl)acetyl]amino}-N-(3-fluorobenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

336. 3-{[(3-chlorophenyl)acetyl]amino}-N-(3-methoxybenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

337. 3-{[(3-chlorophenyl)acetyl]amino}-N-(3-methylbenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

338. 3-{[(3-chlorophenyl)acetyl]amino}-N-(4-fluorobenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

339. N-(4-chlorobenzyl)-3-{[(3-chlorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

340. 3-{[(3-chlorophenyl)acetyl]amino}-N-(4-methoxybenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

341. 3-{[(3-chlorophenyl)acetyl]amino}-N-(4-methylbenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

342. N-(3-chlorobenzyl)-3-{[(3-chlorophenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

343. N-benzyl-3-{[(3-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

344. N-(2-fluorobenzyl)-3-{[(3-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

345. N-(2-chlorobenzyl)-3-{[(3-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

346. N-(2-methoxybenzyl)-3-{[(3-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

347. 3-{[(3-methoxyphenyl)acetyl]amino}-N-(2-methylbenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

348. N-(3-fluorobenzyl)-3-{[(3-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

349. N-(3-methoxybenzyl)-3-{[(3-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

350. 3-{[(3-methoxyphenyl)acetyl]amino}-N-(3-methylbenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

351. N-(4-fluorobenzyl)-3-{[(3-methoxyphenyl)acetyl]amino }-1H-thieno[2,3-c]pyrazole-5-carboxamide;

352. N-(4-chlorobenzyl)-3-{[(3-methoxyphenyl)acetyl]amino}-!H-thieno[2,3-c]pyrazole-5-carboxamide;

353. N-(4-methoxybenzyl)-3-{[(3-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

354. 3-{[(3-methoxyphenyl)acetyl]amino}-N-(4-methylbenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

355. N-(3-chlorobenzyl)-3-{[(3-methoxyphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

356. N-benzyl-3-{[(3-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

357. N-(2-fluorobenzyl)-3-{[(3-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

358. N-(2-chlorobenzyl)-3-{[(3-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

359. N-(2-methoxybenzyl)-3-{[(3-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

360. N-(2-methylphenyl)-3-{[(3-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

361. N-(3-fluorobenzyl)-3-{[(3-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

362. N-(3-methoxybenzyl)-3-{[(3-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

363. N-(3-methylbenzyl)-3-{[(3-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

364. N-(4-fluorobenzyl)-3-{[(3-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

365. N-(4-chlorobenzyl)-3-{[(3-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

366. N-(4-methoxybenzyl)-3-{[(3-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

367. N-(4-methylbenzyl)-3-{[(3-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

368. N-(3-chlorobenzyl)-3-{[(3-methylphenyl)acetyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

369. N-benzyl-3-[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

370. N-(2-fluorobenzyl)-3-[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

371. N-(2-chlorobenzyl)-3-[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

372. N-(2-methoxybenzyl)-3-[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

373. N-(2-methylbenzyl)-3-[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

374. N-(3-fluorobenzyl)-3-[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

375. N-(3-methoxybenzyl)-3-[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

376. N-(3-methylbenzyl)-3-[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

377. N-(4-fluorobenzyl)-3-[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

378. N-(4-chlorobenzyl)-3-[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

379. N-(4-methoxybenzyl)-3-[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

380. N-(4-methylbenzyl)-3-[(thien-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

381. N-(3-chlorobenzyl)-3-[(thien-2-ylcarbonyl)amino]1H-thieno[2,3-c]pyrazole-5-carboxamide;

382. N-benzyl-3-(isonicotinoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

383. N-(2-fluorobenzyl)-3-(isonicotinoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

384. N-(2-chlorobenzyl)-3-(isonicotinoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

385. 3-(isonicotinoylamino)-N-(2-methoxybenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

386. 34isonicotinoylamino)-N-(2-methylbenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

387. N-(3-fluorobenzyl)-3-(isonicotinoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

388. 3-(isonicotinoylamino)-N-(3-methoxybenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

389. 3-(isonicotinoylamino)-N-(3-methylbenzyl )-1H-thieno[2,3-c]pyrazole-5-carboxamide;

390. N-(4-fluorobenzyl)-3-(isonicotinoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

391. N-(4-chlorobenzyl)-3-(isonicotinoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

392. 3-(isonicotinoylamino)-N-(4-methoxybenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

393. 3-(isonicotinoylamino)-N-(4-methylbenzyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

394. N-(3-chlorobenzyl)-3-(isonicotinoylamino)-1H-thieno[2,3-c]pyrazole-5-carboxamide;

395. N-benzyl-3-[(1,3-thiazol-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

396. N-(2-fluorobenzyl)-3-[(1,3-thiazol-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

397. N-(2-chlorobenzyl)-3-[(1,3-thiazol-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

398. N-(2-methoxybenzyl)-3-[(1,3-thiazol-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

399. N-(2-methylbenzyl)-3-[(1,3-thiazol-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

400. N-(3-fluorobenzyl)-3-[(1,3-thiazol-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

401. N-(3-methoxybenzyl)-3-[(1,3-thiazol-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

402. N-(3-methylbenzyl)-3-[(1,3-thiazol-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

403. N-(4-fluorobenzyl)-3-[(1,3-thiazol-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

404. N-(4-chlorobenzyl)-3-[(1,3-thiazol-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

405. N-(4-methoxybenzyl)-3-[(1,3-thiazol-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

406. N-(4-methylbenzyl)-3-[(1,3-thiazol-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

407. N-(3-chlorobenzyl)-3-[(1,3-thiazol-2-ylcarbonyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

408. N-benzyl-3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

409. N-(2-fluorobenzyl)-3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

410. N-(2-chlorobenzyl)-3-{[4-(4-methylpiperazin-1-ylbenzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

411. N-(2-methoxybenzyl)-3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

412. N-(2-methylbenzyl)-3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

413. N-(3-fluorobenzyl)-3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide; 414. N-(3-methoxybenzyl)-3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

415. N-(3-methylbenzyl)-3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

416. N-(4-fluorobenzyl)-3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide; 417. N-(4-chlorobenzyl)-3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

418. N-(4-methoxybenzyl)-3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

419. N-(4-methylbenzyl)-3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

420. N-(3-chlorobenzyl)-3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxamide;

421. N-benzyl-3-[(4-morpholin-4-ylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

422. N-(2-fluorobenzyl)-3-[(4-morpholin-4-ylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

423. N-(2-chlorobenzyl)-3-[(4-morpholin-4-ylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

424. N-(2-methoxybenzyl)-3-[(4-morpholin-4-ylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

425. N-(2-methylbenzyl)-3-[(4-morpholin-4-ylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

426. N-(3-fluorobenzyl)-3-[(4-morpholin-4-ylbenzoyl)amino]-1 H-thieno[2,3-c]pyrazole-5-carboxamide;

427. N-(3-methoxybenzyl)-3-[(4-morpholin-4-ylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

428. N-(3-methylbenzyl)-3-[(4-morpholin-4-ylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

429. N-(4-fluorobenzyl)-3-[(4-morpholin-4-ylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

430. N-(4-chlorobenzyl)-3-[(4-morpholin-4-ylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

431. N-(4-methoxybenzyl)-3-[(4-morpholin-4-ylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide;

432. N-(4-methylbenzyl)-3-[(4-morpholin-4-ylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide; or

433. N-(3-chlorobenzyl)-3-[(4-morpholin-4-ylbenzoyl)amino]-1H-thieno[2,3-c]pyrazole-5-carboxamide.

5. A compound of formula (I) or a pharmaceutically acceptable salt, according to claim 1 , which is tert-butyl 3-amino-1H-thieno[2,3-c]pyrazole-5-carboxylate.

6. A pharmaceutical composition comprising a compound of formula (I), as defined in claim 1 , or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier and/or diluent.

7. A process for preparing a compound of formula (I) and the pharmaceutically acceptable salts thereof as defined in claim 1 , which process comprises:

a) reacting a compound of formula (II)

wherein R 1 , R 2 and X are as defined in claim 1 and R 3 is a lower alkyl group, with hydrazine or a hydrazine salt, so as to obtain a compound of formula (I) wherein R is hydrogen and R 1 , R 2 and X are as defined above; and, if desired,

b) converting the thus obtained compound of formula (I) into another compound of formula (I) wherein R is other than a hydrogen atom; and/or, if desired, converting the compound of formula (I) into a pharmaceutically acceptable salt thereof and/or the salt of a compound of formula (I) into a free compound thereof.