Topical emulsion-gel composition comprising diclofenac sodium
View Patent ↗The invention relates to beneficial topical pharmaceutical compositions comprising diclofenac sodium salt in unusually low amounts. The compositions represent opaque emulsion-gels, in which diclofenac is kept fully dissolved.
1. A pharmaceutical topical use in the form of an emulsion gel consisting of:
(a) 0.1% (w/w) of diclofenac sodium salt,
(b) 76.57% (w/w) of water,
(c) 10.0% (w/w) of isopropanol,
(d) 5.0% (w/w) of propylene glycol,
(e) 0.7% (w/w) of Carbomer 980,
(f′) 2.5% (w/w) of liquid paraffin,
(f″) 2.5% (w/w) of coco-caprylate/caprate,
(g) 2.0% (w/w) polyoxethylene-20-cetostearyl ether, and
(h) 0.63% (w/w) ammonia, concentrated solution in water.
2. A pharmaceutical composition in the form of an emulsion gel for topical use consisting of:
(a) 0.10% (w/w) of diclofenac sodium salt,
(b) 74.9% (w/w) of water,
(d) 15.0% (w/w) of propylene glycol,
(e) 1.0% (w/w) of Carbomer 974P,
(f′) 2.5% (w/w) of liquid paraffin,
(f″) 2.5% (w/w) of coco-caprylate/caprate,
(g) 2.0% (w/w) polyoxethylene-20-cetostearyl ether,
(h) 1.5% (w/w) 30% aqueous NaOH solution, and
(i) 0.5% (w/w) benzyl alcohol.
3. A pharmaceutical composition in the form of a sprayable emulsion gel consisting of:
(a) 0.10% (w/w) of diclofenac sodium salt,
(b) 86.68% (w/w) of water,
(d) 5.0% (w/w) of propylene glycol,
(e) 0.3% (w/w) of Carbomer 974P,
(f′) 2.5% (w/w) of liquid paraffin,
(f″) 2.5% (w/w) of coco-caprylate/caprate,
(g) 2.0% (w/w) polyoxethylene-20-cetostearyl ether,
(h) 0.42% (w/w) 30% aqueous NaOH solution, and
(i) 0.5% (w/w) benzyl alcohol.