IP Library › Granted Patent US 9,675,728
Granted Patent B2
US 9,675,728 · App. 10/528,262 · Granted Jun 13, 2017

Compositions for wound treatment

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Quick Facts
Patent No.
US 9,675,728
App. No.
10/528,262
Granted
Jun 13, 2017
Kind
B2
Abstract

A wound dressing composition comprising a chitosan and an oxidized cellulose. For example, the composition may be in the form of a sponge formed by freeze drying an aqueous dispersion of chitosan and oxidized regenerated cellulose (ORC). The composition is especially suitable for the treatment of chronic wounds.

Claims (17)

1. A wound dressing composition comprising an intimate mixture of:

a chitosan;

an oxidized regenerated cellulose, wherein the weight ratio of the chitosan to the oxidized regenerated cellulose is in the range of about 2:1 to 1:2; and

from about 0.01% to about 5% by weight on a dry weight basis of platelet derived growth factor (PDGF);

wherein the pH of the intimate mixture is in the range of about 2 to 8.

2. A wound dressing composition according to claim 1 , wherein said oxidized regenerated cellulose is in the form of dispersed fibers or powder.

3. A wound dressing composition according to claim 1 , wherein

said oxidized regenerated cellulose and chitosan are dispersed in a semi-solid or solid vehicle for topical application.

4. A wound dressing composition according to claim 1 , wherein the oxidized regenerated cellulose and chitosan together make up at least 25% by weight of the intimate mixture on a dry weight basis.

5. A wound dressing composition according to claim 4 , wherein the oxidized regenerated cellulose and the chitosan together make up at least 50% by weight of the intimate mixture on a dry weight basis.

6. A wound dressing composition according to claim 1 , wherein the composition is a flexible film.

7. A wound dressing comprising a wound dressing composition according to claim 1 .

8. A wound dressing according to claim 7 , which is sterile and packaged in a microorganism-impermeable container.

9. A method of preparing an active wound dressing material comprising the steps of:

(i) preparing a material comprising a composition according to claim 1 ; and

(ii) washing and drying the material to form said active wound dressing material.

10. A wound dressing composition according to claim 1 , wherein the pH of the intimate mixture is in the range of about 3 to 7.

Assignments (18)
RELEASE OF SECURITY INTEREST IN PATENTS Recorded Nov 7, 2019
From: WILMINGTON TRUST, NATIONAL ASSOCIATION
To: KCI USA, INC.; KCI LICENSING, INC.
Reel/Frame 050966/0547 →
RELEASE OF SECURITY INTEREST IN PATENTS Recorded Nov 6, 2019
From: WILMINGTON TRUST, NATIONAL ASSOCIATION
To: KINETIC CONCEPTS, INC.; KCI USA, INC.; ACELITY L.P. INC.; CHIRON HOLDINGS, INC.; CHIRON TOPCO, INC.; KCI ANIMAL HEALTH, LLC; KCI HOLDING COMPANY, INC.; KCI HOMECARE, INC.; KCI IMPORTS, INC.; KCI INTERNATIONAL, INC.; KCI LICENSING, INC.; KCI PROPERTIES LIMITED; KCI REAL HOLDINGS, L.L.C.; KCI REAL PROPERTY LIMITED; KCI USA REAL HOLDINGS, L.L.C.; TECHNIMOTION, LLC
Reel/Frame 050945/0278 →
RELEASE OF SECURITY INTEREST Recorded Oct 11, 2019
From: BANK OF AMERICA, N.A.
To: KCI USA, INC.
Reel/Frame 050710/0955 →
RELEASE OF SECURITY INTEREST REEL/FRAME 040098/0268 Recorded Feb 8, 2017
From: WILMINGTON TRUST
To: KCI USA, INC.
Reel/Frame 041666/0320 →
SECURITY AGREEMENT Recorded Feb 7, 2017
From: KCI USA, INC., AS GRANTOR
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 041650/0013 →
RELEASE OF SECURITY INTEREST IN INTELLECTUAL PROPERTY Recorded Feb 6, 2017
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: KCI LICENSING, INC., AS GRANTOR; TECHNIMOTION, LLC, A DELAWARE LIMITED LIABILITY COMPANY, AS GRANTOR; SYSTAGENIX WOUND MANAGEMENT (US), INC., A DELAWARE CORPORATION, AS GRANTOR
Reel/Frame 041395/0044 →
LIMITED THIRD LIEN INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Oct 7, 2016
From: KCI USA, INC.; LIFECELL CORPORATION; KCI LICENSING, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 040291/0237 →
SECOND LIEN SECURITY AGREEMENT Recorded Sep 21, 2016
From: KCI USA, INC.; LIFECELL CORPORATION; KCI LICENSING, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 040098/0268 →
SECURITY INTEREST Recorded Feb 17, 2016
From: KINETIC CONCEPTS, INC.; KCI USA, INC.; ACELITY L.P. INC.; CHIRON HOLDINGS, INC.; CHIRON TOPCO, INC.; KCI ANIMAL HEALTH, LLC; KCI HOLDING COMPANY, INC.; KCI HOMECARE, INC.; KCI IMPORTS, INC.; KCI INTERNATIONAL, INC.; KCI LICENSING, INC.; KCI PROPERTIES LIMITED; KCI REAL HOLDINGS, L.L.C.; KCI REAL PROPERTY LIMITED; KCI USA REAL HOLDINGS, L.L.C.; LIFECELL CORPORATION; TECHNIMOTION, LLC
To: WILMINGTON TRUST, NATIONAL ASSOCIATION
Reel/Frame 037845/0497 →
MERGER AND CHANGE OF NAME Recorded May 11, 2015
From: SYSTAGENIX WOUND MANAGEMENT (US),INC.; KCI USA, INC.
To: KCI USA, INC.
Reel/Frame 035645/0178 →
MERGER AND CHANGE OF NAME Recorded Feb 11, 2015
From: SYSTAGENIX WOUND MANAGEMENT (US), INC.; KCI USA, INC.
To: KCI USA, INC.
Reel/Frame 034954/0870 →
SECURITY AGREEMENT Recorded Oct 29, 2013
From: SYSTAGENIX WOUND MANAGEMENT (US), INC.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 031508/0011 →
RELEASE OF SECURITY INTEREST Recorded Oct 28, 2013
From: J.P. MORGAN EUROPE LIMITED
To: SYSTAGENIX WOUND MANAGEMENT (US), INC.
Reel/Frame 031506/0186 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 21, 2010
From: JOHNSON & JOHNSON MEDICAL LIMITED
To: SYSTAGENIX WOUND MANAGEMENT IP CO. B.V.
Reel/Frame 024563/0265 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 21, 2010
From: ETHICON, INC.; JOHNSON & JOHNSON; JOHNSON & JOHNSON MEDICAL LIMITED; JOHNSON & JOHNSON MEDICAL B.V.; JANSSEN PHARMACEUTICA N.V.; CILAG AG; CILAG HOLDING AG; JEVCO LIMITED
To: SYSTAGENIX WOUND MANAGEMENT (US), INC.; SYSTAGENIX WOUND MANAGEMENT IP CO. B.V.
Reel/Frame 024563/0368 →
SECURITY AGREEMENT Recorded Jan 30, 2009
From: SYSTAGENIX WOUND MANAGEMENT (US), INC.
To: J.P. MORGAN EUROPE LIMITED
Reel/Frame 022177/0037 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 8, 2009
From: ETHICON, INC.; JOHNSON & JOHNSON MEDICAL LIMITED
To: SYSTAGENIX WOUND MANAGEMENT (US), INC.
Reel/Frame 022071/0762 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 16, 2005
From: CULLEN, BREDA M.; SILCOCK, DEREK WALTER
To: ETHICON, INC.
Reel/Frame 017026/0248 →