IP Library › Granted Patent US 7,521,205
Granted Patent B2
US 7,521,205 · App. 10/529,381 · Granted Apr 21, 2009

Genes and polypeptides relating to prostate cancers

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Quick Facts
Patent No.
US 7,521,205
App. No.
10/529,381
Granted
Apr 21, 2009
Kind
B2
Abstract

The present application provides novel human gene MICAL2-PV whose expression is markedly elevated in prostate cancers. Furthermore, it provides polypeptides encoded by the gene as well as polypeptides encoded by PCOTH which expression was also discovered to be elevated in prostate cancers. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of prostate cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of prostate cancer.

Claims (7)

1. A substantially pure polypeptide comprising the entirety of the amino acid sequence of SEQ ID NO: 4.

2. A method for producing the polypeptide of claim 1 , said method comprising the steps of:

(a) culturing a host cell comprising:

(1) a polynucleotide encoding the polypeptide; or

(2) a vector comprising the polynucleotide encoding the polypeptide;

(b) allowing the host cell to express the polypeptide; and

(c) collecting the expressed polypeptide.

Assignments (6)
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE'S NAME FROM ONCOTHERAPHY SCIENCE, INC. TO ONCOTHERAPY SCIENCE, INC. PREVIOUSLY RECORDED ON REEL 018669 FRAME 0205. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT OF ASSIGNOR'S INTEREST. Recorded Feb 5, 2007
From: THE UNIVERSITY OF TOKYO
To: ONCOTHERAPY SCIENCE, INC.
Reel/Frame 018853/0223 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 21, 2006
From: THE UNIVERSITY OF TOKYO
To: ONCOTHERAPHY SCIENCE, INC.
Reel/Frame 018669/0205 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 29, 2005
From: NAKAMURA, YUSUKE; KATAGIRI, TOYOMASA; NAKAGAWA, HIDEWAKI
To: ONCOTHERAPY SCIENCE, INC.; JAPAN AS REPRESENTED BY THE PRESIDENT OF THE UNIVERSITY OF TOKYO
Reel/Frame 016827/0972 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 29, 2005
From: NAKATSURU, SHUICHI
To: ONCOTHERAPY SCIENCE, INC.
Reel/Frame 016827/0976 →
TRANSLATION OF JAPANESE NATIONAL UNIVERSITY CORPORATION LAW PROVIDING, IN PART, THE SUCCESSION OF RIGHTS AND OBLIGATIONS CURRENTLY ATTRIBUTABLE TO THE NATIONAL GOVERNMENT TO THE UNIVERSITY OF TOKYO Recorded Nov 29, 2005
From: JAPAN AS REPRESENTED BY THE PRESIDENT OF THE UNIVERSITY OF TOKYO
To: UNIVERSITY OF TOKYO THE
Reel/Frame 016828/0001 →
TRANSLATION OF JAPANESE CERTIFICATE OF TOTAL HISTORICAL RECORD INDICATING THAT THE UNIVERSITY OF TOKYO WAS ESTABLISHED AS A NATIONAL UNIVERSITY CORPORATION UNDER THE JAPANESE NATIONAL UNIVERSITY CORPORATION LAW Recorded Nov 29, 2005
From: JAPAN AS REPRESENTED BY THE PRESIDENT OF THE UNIVERSITY OF TOKYO
To: UNIVERSITY OF TOKYO THE
Reel/Frame 016828/0043 →