Use of protein tyrosine phosphatase inhibitors for prevention and/or treatment of cancer
The invention relates to the use of a protein tyrosine phosphatase inhibitor, such as a cross-linker of a protein tyrosine phosphatase (PTP), in particular Sap-1, in the preparation of a medicament for treatment and/or prevention of cancer, and to methods of treating and/or preventing cancer using these inhibitors.
1 .- 15 . (canceled)
16 . A method to treat or prevent cancer comprising administering to an individual a cross-linking agent capable of cross-linking at least two molecules of the protein tyrosine phosphatase Sap-1.
17 . The method of claim 16 , wherein the cancer is a src-associated cancer.
18 . The method of claim 16 , wherein the cancer is a gastrointestinal cancer.
19 . The method of claim 18 , wherein the gastrointestinal cancer is selected from the group consisting of esophageal tumor, stomach cancer, small-bowel tumor, large-bowel tumor, and pancreatic cancer.
20 . The method of claim 16 , wherein the cross-linking agent is a proteinaceous cross-linker.
21 . The method of claim 20 , wherein the proteinaceous cross-linker is an antibody directed against the extra-cellular domain of Sap-1.
22 . The method of claim 21 , wherein the antibody is directed against a Fibronectin-type III like domain of Sap-1.
23 . The method of claims 20 , wherein the cross-linking agent is a monoclonal antibody.
24 . The method of claims 21 , wherein the cross-linking agent is a monoclonal antibody.
25 . The method of claim 20 , wherein the cross-linking agent is a humanized antibody.
26 . The method of claims 21 , wherein the cross-linking agent is a humanized antibody.
27 . The method of claim 20 , wherein the cross-linking agent is a human antibody.
28 . The method of claims 21 , wherein the cross-linking agent is a human antibody.
29 . The method of claim 20 , wherein the cross-linking agent is a soluble fragment of the extracellular domain of Sap-1.
30 . The method of claim 20 , wherein the cross-linking agent comprises one, two, three, four, five, six, seven or eight Fibronectin-type III like repeats of Sap-1.
31 . The method of claim 20 , wherein the cross-linking agent is selected from the group consisting of: a mutein of the proteinaceous cross-linking agent, a fused protein of the proteinaceous cross-linking agent, a functional derivative of the proteinaceous cross-linking agent, an active fraction of the proteinaceous cross-linking agent, and salt of the proteinaceous cross-linking agent.
32 . The method of claim 20 , wherein the cross-linking agent is a functional derivative of the proteinaceous cross-linking agent comprising at least one moiety attached to one or more functional groups, which occur as one or more side chains on the amino acid residues.
33 . The method of claim 32 , wherein the moiety is a polyethylene moiety.