2-beta -modified-6-substituted adenosine analogs and their use as antiviral agents

1. A compound accordine to Formula 1

wherein Z is selected from the group consisting of alkyl, haloalkyl, hydroxyalkyl, O-alkyl, O-haloalkyl, O-hydroxyalkyl, alkenyl, haloalkenyl, hydroxyalkenyl, alkynyl, haloalkynyl, hydroxyalkynyl, and CN;

R 3 and R 4 are independently selected from the group consisting of H, alkyl, substituted alkyl, cycloalkyl, alkoxy, alkaryl, aryl, heteroaryl, substituted aryl, acyl, substituted acyl, and alkylsulfonyl; and

R is selected from the group consisting of H,

wherein BR 1 and B′R 2 are independently selected from the group consisting of OCH 2 CH 2 SC(═O)t-butyl, OCH 2 OC(═O)iPr, and NH-acyl, where acyl is an amino acid acyl group;

V, W, and W′ are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, alkaryl, and substituted alkaryl; and

B and B′ are independently O or NH; and

Z′ is hydrogen, CHWOH, CHWOCOW′, SW, or CH 2 aryl.

2. The compound of claim 1 wherein R 3 is H or CH 3 , and wherein R 4 is selected from the group consisting of H, CHO, C(O)CH 3 , C(O)OCH 3 , S(O) 2 CH 3 , and CH 3 .

3. The compound of claim 1 wherein V is m-chlorophenyl.

4. The compound of claim 2 wherein V is m-chlorophenyl.

5. The compound of claim 2 wherein R is H.