Substituted quinazolines as antiviral agents, especially against cytomegaloviruses

1. A compound of the formula

in which

R 1 , R 2 and R 3 are independently of one another hydrogen, alkyl, alkoxy, carboxyl, alkylcarbonyl, alkoxycarbonyl, aminocarbonyl, trifluoromethyl, halogen, cyano, hydroxy or nitro,

R 4 and R 5 are independently of one another hydrogen, alkyl, alkoxy, cyano, halogen, nitro, trifluoromethyl or trifluoromethoxy,

R 6 is alkyl, cyano, halogen, nitro or trifluoromethyl,

R 7 and R 8 are independently of one another hydrogen, halogen, alkyl or alkoxy, and

R 9 is aryl or 1,3-benzodioxol-5-yl in which aryl and 1,3-benzodioxol-5-yl may be substituted by 1 to 3 substituents, where the substituents are selected independently of one another from the group consisting of alkyl, alkoxy, alkylthio, carboxyl, alkylcarbonyl, alkoxycarbonyl, aminocarbonyl, trifluoromethyl, halogen, carbamoyl, cyano, hydroxy, amino, alkylamino, nitro and optionally hydroxy-substituted alkyl,

or a salt thereof.

2. A compound according to claim 1 , in which

R 1 , R 2 and R 3 are independently of one another hydrogen, fluorine, chlorine, cyano, hydroxy, aminocarbonyl or nitro,

R 4 and R 5 are independently of one another hydrogen, fluorine, alkyl or alkoxy,

R 6 is trifluoromethyl, isopropyl or tert-butyl,

R 7 and R 8 are independently of one another hydrogen, halogen, C 1 -C 3 -alkyl or C 1 -C 3 -alkoxy, and

R 9 is phenyl or 1,3-benzodioxol-5-yl in which phenyl may be substituted by 1to 3 substituents, where the substituents are selected independently of one another from the group consisting of C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, carboxyl, C 1 -C 6 -alkylcarbonyl, C 1 -C 6 -alkoxycarbonyl, trifluoromethyl, fluorine, chlorine, bromine, cyano, hydroxy, amino, C 1 -C 6 -alkylamino and nitro,

or a salt thereof.

3. A compound according to claim 1 , in which

R 1 and R 2 are hydrogen,

R 3 is fluorine,

R 4 and R 5 are independently of one another hydrogen, fluorine or alkoxy,

R 6 is trifluoromethyl,

R 7 and R 8 are hydrogen and

R 9 is phenyl, in which phenyl may be substituted by 1 or 2 substituents, where the substituents are selected independently of one another from the group consisting of methyl, methoxy, fluorine and chlorine,

or a salt thereof.

4. A process for preparing a compound of the formula (I) as claimed in claim 1 , comprising the step of reacting a compound of the formula

in which

R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 have the meaning indicated in claim 1 , and

R 10 is alkyl, with a base.

5. A pharmaceutical composition comprising a compound according to claim 1 in combination with an inert, nontoxic, pharmaceutically suitable excipient.

6. A pharmaceutical composition according to claim 5 for the treatment of viral infections.

7. A method for treating viral infections in humans and animals by administering an antivirally effective amount of at least one compound according to claim 1 .

8. The method of claim 7 wherein said infection is caused by a virus of the group Herpes viridae.

9. The method of claim 8 wherein said virus is a cytomegalovirus.

10. The method of claim 9 wherein said virus is human cytomegalovirus (HCMV).

11. A method for controlling viral infections in humans and animals by administering an antivirally effective amount of a pharmaceutical composition according to claim 5 .

12. The method of claim 11 wherein said infection is caused by a virus of the group Herpes viridae.

13. The method of claim 12 wherein said virus is a cytomegalovirus.

14. The method of claim 13 wherein said virus is human cytomegalovirus (HCMV).

15. The process of claim 4 wherein R 10 is methyl or ethyl.