Remedy for overactive bladder comprising acetic acid anilide derivative as the active ingredient
(R)-2-(2-aminothiazol-4-yl)-4′-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetic acid anilide or its salt shows a potent bladder relaxation effect in “isolated rat bladder smooth muscle relaxation test”, dose-dependently lowers the contraction frequency of rhythmic bladder contractions in “rat rhythmic bladder contraction measurement test” and, moreover, prolongs the urination intervals in “urination functions measurement test on cyclophosphamide-induced overactive bladder model rat”. Owing to these effects, the above compound is useful as a remedy for ovaractive bladder.
1. A method for treating overactive bladder comprising administering to a subject in need thereof, a pharmaceutically effective amount of (R)-2-(2-aminothiazol-4-yl)-4′-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetic acid anilide or a salt thereof as an active ingredient, wherein the subject is not suffering from diabetes.
2. The method according to claim 1 , wherein the overactive bladder is a result of benign prostatic hyperplasia.
3. The method according to claim 1 , wherein the subject has urinary urgency.
4. The method according to claim 1 , wherein the subject has urinary urge incontinence.
5. The method according to claim 1 , wherein the subject has pollakiuria.
6. A method for treating overactive bladder comprising administering to a subject in need thereof, a pharmaceutically effective amount of (R)-2-(2-aminothiazol-4-yl)-4′-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetic acid anilide, in its free base form, as an active ingredient, wherein the subject is not suffering from diabetes.
7. The method according to claim 6 , wherein the overactive bladder is a result of benign prostatic hyperplasia.
8. The method according to claim 6 , wherein the subject has urinary urgency.
9. The method according to claim 6 , wherein the subject has urinary urge incontinence.
10. The method according to claim 6 , wherein the subject has pollakiuria.
11. The method according to claim 1 , wherein the subject is human.
12. The method according to claim 6 , wherein the subject is human.