Device for ocular delivery of active principles by the transpalpebral route
The invention relates to a device for ocular delivery of active principle(s) ( 1 ) comprising a first outer layer ( 2 ) which is essentially non-leaking, and a second inner layer ( 3 ) which has a surface ( 7 ) able to come into contact with at least one eyelid. characterized in that the second layer comprises at least one active principle intended to be delivered to the patient through the eyelid.
1 . Device for ocular delivery of active principle(s) ( 1 ; 10 ; 20 ; 30 ; 40 ) comprising a first outer layer ( 2 ; 12 ; 22 ; 32 ; 42 ) which is essentially non-leaking, and a second inner layer ( 3 ; 13 ; 23 ; 33 ; 43 ) which has a surface ( 7 ) able to come into contact with at least one eyelid, characterized in that the second layer comprises at least one active principle intended to be delivered through the eyelid.
2 . Device according to claim 1 , characterized in that the first, non-leaking layer has an inner face ( 8 ), and the second layer ( 3 ) partially overlies the inner face ( 8 ).
3 . Device according to claim 2 , characterized in that a part ( 6 ) of the inner face ( 8 ) not overlied by the second layer ( 3 ) can be overlied with a cutaneous adhesive.
4 . Device according to one of claims 1 to 3 , characterized in that the device for ocular delivery ( 20 ) comprises at least two parts ( 24 , 25 ).
5 . Device according to one of claims 1 to 4 , characterized in that the device has an orifice ( 34 ) at its centre.
6 . Device according to one of claims 1 to 5 , characterized in that it additionally comprises a reservoir ( 44 ) able to be brought into communication with the second layer ( 43 ) via means of communication ( 45 , 46 ).
7 . Device according to claim 6 , characterized in that the means of communication is a protective seal ( 45 ) able to insulate the reservoir of the second layer in a non-leaking manner before its withdrawal.
8 . Device according to one of claims 1 to 7 , characterized in that the layer ( 2 ) is a rigid or semi-rigid shell ( 52 ).
9 . Device according to claim 8 , characterized in that the rigid or semi-rigid shell has, on an outer face, application means ( 54 ).