Selective non-steroidal glucocorticoid receptor modulators
View Patent ↗The present invention encompasses compounds of Formula (I) or pharmaceutically acceptable salts or hydrates thereof, which are useful as novel non-steroidal selective glucocorticoid receptor modulators for treating a variety of autoimmune and inflammatory diseases or conditions, and possess advantages over steroidal glucocorticoid ligands with respect to undesireable side-effects, efficacy, toxicity and/or metabolism. Pharmaceutical compositions and methods of use are also included.
1. A compound of Formula II:
or a pharmaceutically acceptable salt or hydrate thereof, wherein:
X is selected from the group consisting of: —OR a , —N(R b )—Y—R c , —S(O) j -R d , wherein:
Y is selected from a bond, —C(O)—, —C(O)—O—, wherein the point of attachment of the “—O—” group is to R c forming an alkoxy moiety, —S(O) 2 — and —C(O)—N(R 12 )—, wherein the point of attachment of the nitrogen group is to R c , and
j is 0, 1 or 2,
n is 1,
R a , R b , R c , R d and R 8 are each independently selected from the group consisting of:
(1) hydrogen, except that R d is not hydrogen and R c is hydrogen only when Y is a bond or —C(O)—N(R 12 )—,
(2) C 1-6 alkyl,
(3) C 2-6 alkenyl,
(4) C 2-6 akynyl,
(5) C 3-6 cycloalkyl,
(6) aryl,
(7) aralkyl,
(8) HET 1 ,
(9) —C 1-6 alkyl-HET 2 ,
(10) aralkenyl,
(11) aralkynyl and
(12) arylsulfonylalkyl,
wherein items (2) to (5) above and the alkyl portions of items (7), (9) and (12) above and the alkenyl portion of item (10) above and the alkynyl portion of item (11) above are optionally substituted with oxo and optionally substituted with one to three substituents independently selected from the group consisting of: halo, OR 11 , N(R 12 ) 2 , C 3-6 cycloalkyl and C 1-4 alkyl-S(O) m —, wherein m is 0, 1 or 2, and
wherein items (6) and (8) above and the aryl portion of items (7), (10), (11) and (12) above and the HET 2 portion of item (9) above are optionally substituted with one to five substituents independently selected from the group consisting of:
(a) halo,
(b) OR 11 ,
(c) N(R 12 ) 2 ,
(d) C 1-6 alkyl,
(e) C 2-6 alkenyl,
(f) C 2-6 akynyl,
(g) C 1-6 alkyl-S(O) p —, wherein p is 0, 1 or 2,
(h) aryl,
(i) aryl-S(O) q —, wherein q is 0, 1 or 2,
(j) HET 3 ,
(k) aralkyl,
(l) aroyl,
(m) aryloxy,
(n) aralkoxy and
(o) CN,
wherein items (d) to (g) above and the alkyl portions of item (k) above are optionally substituted with one to three substituents independently selected from the group consisting of: halo, OR 11 and N(R 12 ) 2 , and
wherein items (h), (i), (j), (l) and (m) above and the aryl portions of items (k) and (n) above are optionally substituted with one to three substituents independently selected from the group consisting of: halo, OR 12 and C 1-4 alkyl,
each R 11 and R 12 is independently selected from the group consisting of hydrogen and C 1-4 alkyl, optionally substituted with 1 to 3 halo groups; and
HET 1 , HET 2 and HET 3 are each independently selected from the group of heterocycles consisting of: benzimidazolyl, benzofuranyl, benzopyrazolyl, benzotriazolyl, benzothiophenyl, benzoxazolyl, carbazolyl, carbolinyl, cinnolinyl, furanyl, imidazolyl, indolinyl, indolyl, indolazinyl, indazolyl, isobenzofuranyl, isoindolyl, isoquinolyl, isothiazolyl, isoxazolyl, naphthyridinyl, oxadiazolyl, oxazolyl, pyrazinyl, pyrazolyl, pyridopyridinyl, pyridazinyl, pyridyl, pyrimidyl, pyrrolyl, quinazolinyl, quinolyl, quinoxalinyl, thiadiazolyl, thiazolyl, thienyl, triazolyl, azetidinyl, 1,4-dioxanyl, hexahydroazepinyl, piperazinyl, piperidinyl, pyrrolidinyl, morpholinyl, thiomorpholinyl, dihydrobenzimidazolyl, dihydrobenzofuranyl, dihydrobenzothiophenyl, dihydrobenzoxazolyl, dihydrofuranyl, dihydroimidazolyl, dihydroindolyl, dihydroisooxazolyl, dihydroisothiazolyl, dihydrooxadiazolyl, dihydrooxazolyl, dihydropyrazinyl, dihydropyrazolyl, dihydropyridinyl, dihydropyrimidinyl, dihydropyrrolyl, dihydroquinolinyl, dihydrotetrazolyl, dihydrothiadiazolyl, dihydrothiazolyl, dihydrothienyl, dihydrotriazolyl, dihydroazetidinyl, methylenedioxybenzoyl, tetrahydrofuranyl, and tetrahydrothienyl.
2. The compound according to claim 1 wherein
X is —OR a ,
and
R a is selected from the group consisting of:
(1) hydrogen,
(2) acetyl,
(3) benzyl,
(4) C 1-6 alkyl,
(5) C 2-6 alkenyl,
(6) C 2-6 alkynyl and
(7) C 3-6 cycloalkyl,
R 8 is selected from the group consisting of:
(1) hydrogen,
(2) C 1-6 alkyl,
(3) C 2-6 alkenyl,
(4) C 2-6 akynyl,
(5) C 3-6 cycloalkyl,
(6) aryl,
(7) aralkyl,
(8) HET 1 ,
(9) —C 1-6 alkyl-HET 2 ,
(10) aralkenyl,
(11) aralkynyl, and
(12) arylsulfonylalkyl
wherein items (2) to (5) above and the alkyl portions of items (7), (9) and (12) above and the alkenyl portion of item (10) above and the alkynyl portion of item (11) above are optionally substituted with oxo and optionally substituted with one to three substituents independently selected from the group consisting of: halo, OR 11 and C 3-6 cycloalkyl,
wherein items (6) and (8) above and aryl portion of items (7), (10), (11) and (12) above and the HET 2 portion of item (9) above are optionally substituted with one to five substituents independently selected from the group consisting of:
(a) halo,
(b) C 1-6 alkyl,
(c) C1-4alkoxy and
(d) aryl,
R 11 is selected from the group consisting of hydrogen and C 1-4 alkyl, optionally substituted with 1 to 3 halo groups; and
HET 1 and HET 2 are each independently selected from the group of heterocycles consisting of: benzimidazolyl, benzofuranyl, benzopyrazolyl, benzotriazolyl, benzothiophenyl, benzoxazolyl, carbazolyl, carbolinyl, cinnolinyl, furanyl, imidazolyl, indolinyl, indolyl, indolazinyl, indazolyl, isobenzofuranyl, isoindolyl, isoquinolyl, isothiazolyl, isoxazolyl, naphthyridinyl, oxadiazolyl, oxazolyl, pyrazinyl, pyrazolyl, pyridopyridinyl, pyridazinyl, pyridyl, pyrimidyl, pyrrolyl, quinazolinyl, quinolyl, quinoxalinyl, thiadiazolyl, thiazolyl, thienyl, triazolyl, azetidinyl, 1,4-dioxanyl, hexahydroazepinyl, piperazinyl, piperidinyl, pyrrolidinyl, morpholinyl, thiomorpholinyl, dihydrobenzimidazolyl, dihydrobenzofuranyl, dihydrobenzothiophenyl, dihydrobenzoxazolyl, dihydrofuranyl, dihydroimidazolyl, dihydroindolyl, dihydroisooxazolyl, dihydroisothiazolyl, dihydrooxadiazolyl, dihydrooxazolyl, dihydropyrazinyl, dihydropyrazolyl, dihydropyridinyl, dihydropyrimidinyl, dihydropyrrolyl, dihydroquinolinyl, dihydrotetrazolyl, dihydrothiadiazolyl, dihydrothiazolyl, dihydrothienyl, dihydrotriazolyl, dihydroazetidinyl, methylenedioxybenzoyl, tetrahydrofuranyl, and tetrahydrothienyl.
3. The compound according to claim 2 wherein:
R 8 is selected from the group consisting of:
(1) hydrogen,
(2) C 1-6 alkyl,
(3) C 2-6 alkenyl,
(4) C 2-6 akynyl,
(5) C 3-6 cycloalkyl,
(6) phenyl or naphthyl,
(7) benzyl or phenethyl,
(8) benzothiophene,
(9) phenylethenyl,
(10) phenylethynyl, and
(11) phenylsulfonylmethyl,
wherein items (2) to (5) above are optionally substituted with one to three substituents independently selected from the group consisting of: halo, OR 11 and C 3-6 cycloalkyl,
wherein item (6) above and the phenyl portions of items (7), (9), (10) and (11) above are optionally substituted with one to five substituents independently selected from the group consisting of:
(a) halo,
(b) C 1-6 alkyl,
(c) C 1-4 alkoxy and
(d) phenyl.
4. The compound according to claim 1 wherein:
X is —N(R b )—Y—R c , wherein:
Y is selected from —C(O)—, C(O)O—, wherein the point of attachment of the “—O—” group is to R c forming an alkoxy moiety, —S(O) 2 — and —C(O)—N(R 12 )—, wherein the point of attachment of the nitrogen group is to R c , and
R 8 is hydrogen,
R b and R c are each independently selected from the group consisting of:
(1) hydrogen, except that R c is not hydrogen,
(2) C 1-6 alkyl,
(3) C 2-6 alkenyl,
(4) C 2-6 akynyl,
(5) C 3-6 cycloalkyl,
(6) aryl,
(7) aralkyl,
(8) HET 1 ,
(9) —C 1-6 alkyl-HET 2 ,
(10) aralkenyl,
(11) aralkynyl and
(12) arylsulfonylalkyl,
wherein items (2) to (5) above and the alkyl portions of items (7), (9) and (12) above and the alkenyl portion of item (10) above and the alkynyl portion of item (11) above are optionally substituted with oxo and optionally substituted with with one to three substituents independently selected from the group consisting of: halo, OR 11 , N(R 12 ) 2 , C 3-6 cycloalkyl and C 1-4 alkyl-S(O) m —, wherein m is 0, 1 or 2, and
wherein items (6) and (8) above and the aryl portion of items (7), (10), (11) and (12) above and the HET 2 portion of item (9) above are optionally substituted with one to five substituents independently selected from the group consisting of:
(a) halo,
(b) OR 11 ,
(c) N(R 12 ) 2 ,
(d) C 1-6 alkyl,
(e) C 2-6 alkenyl,
(f) C 2-6 akynyl,
(g) C 1-6 alkyl-S(O) p —, wherein p is 0, 1 or 2,
(h) aryl,
(i) aryl-S(O) q —, wherein q is 0, 1 or 2,
(j) HET 3 ,
(k) aralkyl,
(l) aroyl,
(m) aryloxy,
(n) aralkoxy and
(o) CN,
wherein items (d) to (g) above and the alkyl portions of item (k) above are optionally substituted with one to three substituents independently selected from the group consisting of: halo, OR 11 and N(R 12 ) 2 , and
wherein items (h), (i), (j), (l) and (m) above and the aryl portions of items (k) and (n) above are optionally substituted with one to three substituents independently selected from the group consisting of: halo, OR 12 and C 1-4 alkyl,
each R 11 and R 12 is independently selected from the group consisting of hydrogen and C 1-4 alkyl, optionally substituted with 1 to 3 halo groups; and
HET 1 , HET 2 and HET 3 are each independently selected from the group of heterocycles consisting of: benzimidazolyl, benzofuranyl, benzopyrazolyl, benzotriazolyl, benzothiophenyl, benzoxazolyl, carbazolyl, carbolinyl, cinnolinyl, furanyl, imidazolyl, indolinyl, indolyl, indolazinyl, indazolyl, isobenzofuranyl, isoindolyl, isoquinolyl, isothiazolyl, isoxazolyl, naphthyridinyl, oxadiazolyl, oxazolyl, pyrazinyl, pyrazolyl, pyridopyridinyl, pyridazinyl, pyridyl, pyrimidyl, pyrrolyl, quinazolinyl, quinolyl, quinoxalinyl, thiadiazolyl, thiazolyl, thienyl, triazolyl, azetidinyl, 1,4-dioxanyl, hexahydroazepinyl, piperazinyl, piperidinyl, pyrrolidinyl, morpholinyl, thiomorpholinyl, dihydrobenzimidazolyl, dihydrobenzofuranyl, dihydrobenzothiophenyl, dihydrobenzoxazolyl, dihydrofuranyl, dihydroimidazolyl, dihydroindolyl, dihydroisooxazolyl, dihydroisothiazolyl, dihydrooxadiazolyl, dihydrooxazolyl, dihydropyrazinyl, dihydropyrazolyl, dihydropyridinyl, dihydropyrimidinyl, dihydropyrrolyl, dihydroquinolinyl, dihydrotetrazolyl, dihydrothiadiazolyl, dihydrothiazolyl, dihydrothienyl, dihydrotriazolyl, dihydroazetidinyl, methylenedioxybenzoyl, tetrahydrofuranyl, and tetrahydrothienyl.
5. The compound according to claim 4 wherein:
R b and R c are each independently selected from the group consisting of:
(1) hydrogen, except that R c is hydrogen only when Y is a bond or —C(O)—N(R 12 )—,
(2) C 1-6 alkyl,
(3) C 2-6 alkenyl,
(4) C 2-6 akynyl,
(5) C 3-6 cycloalkyl,
(6) aryl,
(7) aralkyl,
(8) HET 1 ,
(9) —C 1-6 alkyl-HET 2 ,
(10) aralkenyl, and
(11) aralkynyl,
wherein items (2) to (5) above are optionally substituted with 1-3 halo groups, and
wherein items (6) and (8) and aryl portion of items (7), (10) and (11) above and the HET 2 portion of item (9) above are optionally substituted with one to five substituents independently selected from the group consisting of:
(a) halo,
(b) C 1-4 alkyl, optionally substituted with 1-3 halo groups, and
(c) C 1-4 alkylthio,
HET 1 and HET 2 are each independently selected from the group of heterocycles consisting of: benzimidazolyl, benzofuranyl, benzopyrazolyl, benzotriazolyl, benzothiophenyl, benzoxazolyl, carbazolyl, carbolinyl, cinnolinyl, furanyl, imidazolyl, indolinyl, indolyl, indolazinyl, indazolyl, isobenzofuranyl, isoindolyl, isoquinolyl, isothiazolyl, isoxazolyl, naphthyridinyl, oxadiazolyl, oxazolyl, pyrazinyl, pyrazolyl, pyridopyridinyl, pyridazinyl, pyridyl, pyrimidyl, pyrrolyl, quinazolinyl, quinolyl, quinoxalinyl, thiadiazolyl, thiazolyl, thienyl, triazolyl, azetidinyl, 1,4-dioxanyl, hexahydroazepinyl, piperazinyl, piperidinyl, pyrrolidinyl, morpholinyl, thiomorpholinyl, dihydrobenzimidazolyl, dihydrobenzofuranyl, dihydrobenzothiophenyl, dihydrobenzoxazolyl, dihydrofuranyl, dihydroimidazolyl, dihydroindolyl, dihydroisooxazolyl, dihydroisothiazolyl, dihydrooxadiazolyl, dihydrooxazolyl, dihydropyrazinyl, dihydropyrazolyl, dihydropyridinyl, dihydropyrimidinyl, dihydropyrrolyl, dihydroquinolinyl, dihydrotetrazolyl, dihydrothiadiazolyl, dihydrothiazolyl, dihydrothienyl, dihydrotriazolyl, dihydroazetidinyl, methylenedioxybenzoyl, tetrahydrofuranyl, and tetrahydrothienyl.
6. The compound according to claim 5 wherein:
R b is selected from the group consisting of: hydrogen and C 1-4 alkyl, and
R c is selected from the group consisting of:
(1) C 1-4 alkyl,
(2) phenyl or benzyl, each optionally substituted with 1 to 5 groups independently selected from fluoro, chloro and trifluoromethyl,
(3) naphthyl,
(4) thiopheneyl,
(5) pyridyl,
(6) isoquinolyl,
(7) pyrimidyl and
(8) pyrazyl,
wherein items (4) to (8) above are optionally substitited with 1 to 5 groups independently selected from fluoro, chloro, methyl, methylthio and trifluoromethyl.
7. The compound according to claim 6 , wherein R c is phenyl, optionally substituted with 1 to 5 groups independently selected from fluoro, chloro and trifluoromethyl.
8. The compound according to claim 1 , wherein:
X is —S(O) j -R d , wherein j is 0, 1 or 2,
R 8 is hydrogen, and
R d is selected from the group consisting of:
(1) C 1-6 alkyl,
(2) C 2-6 alkenyl,
(3) C 2-6 akynyl,
(4) C 3-6 cycloalkyl,
(5) aryl,
(6) aralkyl,
(7) HET 1 ,
(8) —C 1-6 alkyl-HET 2 ,
(9) aralkenyl, and
(10) aralkynyl,
wherein items (1) to (4) above are optionally substituted with 1-3 halo groups, and
wherein items (5) and (7) and aryl portion of items (6), (9) and (10) above and the HET 2 portion of item (8) above are optionally substituted with one to five substituents independently selected from the group consisting of:
(a) halo,
(b) C 1-4 alkyl, optionally substituted with 1-3 halo groups, and
(c) C 1-4 alkylthio, and
HET 1 and HET 2 are each independently selected from the group of heterocycles consisting of: benzimidazolyl, benzofuranyl, benzopyrazolyl, benzotriazolyl, benzothiophenyl, benzoxazolyl, carbazolyl, carbolinyl, cinnolinyl, furanyl, imidazolyl, indolinyl, indolyl, indolazinyl, indazolyl, isobenzofuranyl, isoindolyl, isoquinolyl, isothiazolyl, isoxazolyl, naphthyridinyl, oxadiazolyl, oxazolyl, pyrazinyl, pyrazolyl, pyridopyridinyl, pyridazinyl, pyridyl, pyrimidyl, pyrrolyl, quinazolinyl, quinolyl, quinoxalinyl, thiadiazolyl, thiazolyl, thienyl, triazolyl, azetidinyl, 1,4-dioxanyl, hexahydroazepinyl, piperazinyl, piperidinyl, pyrrolidinyl, morpholinyl, thiomorpholinyl, dihydrobenzimidazolyl, dihydrobenzofuranyl, dihydrobenzothiophenyl, dihydrobenzoxazolyl, dihydrofuranyl, dihydroimidazolyl, dihydroindolyl, dihydroisooxazolyl, dihydroisothiazolyl, dihydrooxadiazolyl, dihydrooxazolyl, dihydropyrazinyl, dihydropyrazolyl, dihydropyridinyl, dihydropyrimidinyl, dihydropyrrolyl, dihydroquinolinyl, dihydrotetrazolyl, dihydrothiadiazolyl, dihydrothiazolyl, dihydrothienyl, dihydrotriazolyl, dihydroazetidinyl, methylenedioxybenzoyl, tetrahydrofuranyl, and tetrahydrothienyl.
9. The compound according to claim 8 , wherein
R d is phenyl, optionally substituted with 1 to 5 groups independently selected from fluoro, chloro and trifluoromethyl.
10. A compound selected from the following group:
n
R Group
1
Vinyl
1
Allyl
1
3-butenyl
1
n-pentyl
1
3-methylbutyl
1
2-cyclohexylethyl
1
3,3-dimethylbutyl
1
4-methyl-3-pentenyl
1
4,4,4-trifluorobutyl
1
3,4,4-trifluoro-3-butenyl
1
3-methoxypropyl
1
2-(2-chlorophenyl)ethyl
1
2-(4-chlorophenyl)ethyl
1
2-(4-fluorophenyl)ethyl
2
2-(4-fluorophenyl)ethyl
1
2-(2,5-difluorophenyl)ethyl
1
2-(2,3-difluorophenyl)ethyl
1
2-(3,5-difluorophenyl)ethyl
1
2-(4-methoxyphenyl)ethyl
1
2-(2-naphthyl)ethyl
1
2-(3-(trifluoromethyl)phenyl)ethyl
1
2-(2-methoxyphenyl)ethyl
1
2-(4-tert-butylphenyl)ethyl
1
2-(4-methylphenyl)ethyl
1
2-(1-naphthyl)ethyl
1
2-(2-methylphenyl)ethyl
1
2-(3-methylphenyl)ethyl
1
2-(2-fluorophenyl)ethyl
1
2-(3-fluorophenyl)ethyl
1
2-(3,4-dichlorophenyl)ethyl
1
2-(2-chloro-4-fluorophenyl)ethyl
1
2-(3-thiopheneyl)ethyl
1
3-(N-pyrrolyl)propyl
1
E-2-phenylethenyl
1
Z-2-phenylethenyl
1
2-(2,4-difluorophenyl)ethynyl
1
2-(2-thiopheneyl)ethyl
1
2-(3,4-difluorophenyl)ethyl
1
2-(3,4,5-trifluorophenyl)ethyl
1
H
n
R i Group
R ii Group
1
H
n-propyl
1
phenethyl
cyclopropylmethyl
1
phenethyl
E-2-butenyl
1
2-(2,4-dichlorophenyl)ethyl
methyl
1
2-(2-chlorophenyl)ethyl
methyl
1
2-(3-chlorophenyl)ethyl
methyl
1
n-pentyl
methyl
1
2-(4-fluorophenyl)ethyl
methyl
1
2-(2,4-dichlorophenyl)ethyl
benzyl
1
2-(2,4-dichlorophenyl)ethyl
allyl
1
2-(2,4-dichlorophenyl)ethyl
n-propyl
1
2-(2-chlorophenyl)ethyl
n-propyl
1
phenethyl
n-propyl
1
phenethyl
methyl
1
2-(3-chlorophenyl)ethynyl
allyl
1
2-(3-chlorophenyl)ethynyl
n-propyl
1
2-(2,4-difluorophenyl)ethyl
methyl
1
phenethyl
E-2-pentenyl
1
trifluoromethyl
allyl
1
trifluoromethyl
n-propyl
1
2-(3-methylphenyl)ethyl
methyl
1
phenethyl
n-butyl
1
phenethyl
n-pentyl
1
2-(3,4-difluorophenyl)ethyl
n-propyl
1
2-(3-fluorophenyl)ethyl
methyl
n
R iii Group
R iv Group
1
CO(3,3,3-trifluoropropyl)
H
1
CO(2-(trifluoromethyl)phenyl)
H
1
CO(3-chlorophenyl)
H
1
COCH 2 (2-(trifluoromethyl)phenyl)
H
1
CO(2,4,5-trifluorophenyl)
H
1
CO(3-thiopheneyl)
H
1
COCH 2 (2,4-difluorophenyl)
H
1
COCH 2 (3-chlorophenyl)
H
1
CO(3-chloro-4-fluorophenyl)
H
1
COCH 2 (2,5-difluorophenyl)
H
1
COCH 2 (2-thiopheneyl)
H
1
COCH 2 (3-thiopheneyl)
H
1
CO(2-chloro-5-fluorophenyl)
H
1
COCH 2 (3-chloro-4-fluorophenyl)
H
1
CO(2,4,5-trifluorophenyl)
methyl
1
CO(2-(trifluoromethyl)phenyl)
methyl
1
CO(2-thiopheneyl)
methyl
1
CO(3-chlorophenyl)
methyl
1
CO(phenyl)
H
1
CO(2,4-difluorophenyl)
H
1
COCH 2 (3-chloro-4-fluorophenyl)
methyl
1
CO(2,4-difluorophenyl)
methyl
1
COCH 2 (2-(trifluoromethyl)phenyl)
methyl
1
CO(2-fluorophenyl)
H
1
CO(2,6-difluorophenyl)
H
1
CO(2-chlorophenyl)
H
1
CO(1-naphthyl)
H
1
CO(2-(trifluoromethyl)-4-fluorophenyl)
H
1
CO(2,5-difluorophenyl)
H
1
CO(2,3-difluorophenyl)
H
1
CO(2-chloro-4-fluorophenyl)
H
1
CO(2-chloro-3-fluorophenyl)
H
1
CO(tert-butyl)
H
1
CO(isopropyl)
H
1
CO(2-chloro-3-fluorophenyl)
methyl
1
CO(2-(trifluoromethyl)-4-fluorophenyl)
methyl
1
CO(2,6-difluorophenyl)
methyl
1
CO(2-chloro-4-fluorophenyl)
methyl
1
SO 2 (phenyl)
H
1
CO(2,6-dichlorophenyl)
methyl
1
CO(2,6-dichlorophenyl)
H
1
SO 2 (2,4-difluorophenyl)
H
1
CO(2,4-difluorophenyl)
n-propyl
1
SO 2 (3-chlorophenyl)
H
2
CO(3-chlorophenyl)
H
1
SO 2 (2-chloro-4-fluorophenyl)
H
1
CO 2 (phenyl)
methyl
1
CO 2 (phenyl)
H
1
CONH(phenyl)
H
1
SO 2 (2-fluorophenyl)
H
1
SO 2 (2-chlorophenyl)
H
1
CONH(phenyl)
methyl
1
SO 2 (2-(trifluoromethyl)phenyl)
H
1
SO 2 (3-fluorophenyl)
H
1
CO(2-chloro-4-fluorophenyl)
n-propyl
1
CO(2-(trifluoromethyl)-4-fluorophenyl)
n-propyl
1
SO 2 (3-chlorophenyl)
methyl
1
SO 2 (2-chloro-4-fluorophenyl)
methyl
1
SO 2 (3-chlorophenyl)
n-propyl
R v Group
R vi Group
CO(phenyl)
H
SO 2 (2-chloro-4-fluorophenyl)
H
CO(2-chlorophenyl)
H
CO(3-chlorophenyl)
H
CO(2-(trifluoromethyl)phenyl)
H
CO(isopropyl)
H
CO(tert-butyl)
H
CO(3-thiopheneyl)
H
CO(2-thiopheneyl)
H
CO(2,4,5-trifluorophenyl)
H
CO(2,5-difluorophenyl)
H
CO 2 (phenyl)
H
SO 2 (phenyl)
H
CO(2-chlorophenyl)
methyl
CO(2-(trifluoromethyl)phenyl)
methyl
CO(3-chlorophenyl)
methyl
CONH(phenyl)
H
CO(2,6-difluorophenyl)
H
COCH 2 (2,4-difluorophenyl)
H
CO(2,4-difluorophenyl)
H
CO(2-fluorophenyl)
H
CO(2-(trifluoromethyl)-4-fluorophenyl)
n-propyl
n
Het (Heterocycle)
R vii Group
1
2-pyridyl
H
1
4-isoquinolyl
H
1
2-(4-methyl)pyridyl
H
1
5-pyrimidyl
H
1
3-pyridyl
H
1
2-pyrimidyl
H
1
2-pyrimidyl
methyl
1
2-pyrimidyl
n-propyl
1
4-(2-methylthio)pyrimidyl
H
1
2-(4-trifluoromethyl)pyridyl
H
1
2-pyrazinyl
H
1
4-(2,3,5,6-tetrafluoro)pyridyl
H
Ar Group
2-chlorophenyl
3-chlorophenyl
2-(trifluoromethyl)phenyl
2,6-dichlorophenyl
2,4-dichlorophenyl
or a pharmaceutically acceptable salt of any compound selected from any of the tables above.
11. A pharmaceutical composition comprising a compound according to claim 1 in combination with a pharmaceutically acceptable carrier.