Primer for dental materials and pulp capping agent for dentin regeneration
View Patent ↗A dental material primer and a dentin-regenerating pulp-capping agent which exhibit an excellent dentin-regenerating action, are disclosed. The dental material primer includes a hydrolyzed ethylene-vinyl acetate copolymer in which collagen is immobilized and the dentin-regenerating pulp-capping agent includes a hydrolyzed ethylene-vinyl acetate copolymer, in which collagen is immobilized, and a binder.
1. A dental material primer comprising a hydrolyzed ethylene-vinyl acetate copolymer in which collagen is immobilized, and a hydroxyl group-containing polymerizable monomer or an acidic group-containing polymerizable monomer as a primer component;
wherein the hydrolyzed ethylene-vinyl acetate copolymer, in which collagen is immobilized, is fine particles having an average particle size of 0.2 μm to 30 μm;
wherein the amount of the hydrolyzed ethylene-vinyl acetate copolymer, in which collagen is immobilized, is 1 to 50% by weight; and
wherein the dental material primer contains a boron compound in an amount of 0.001 to 0.1 part by weight converted to boron content based on 100 parts by weight of the hydrolyzed ethylene-vinyl acetate copolymer, in which collagen is immobilized.
2. A dentin-regenerating pulp-capping agent comprising a hydrolyzed ethylene-vinyl acetate copolymer in which collagen is immobilized, and a binder;
wherein the hydrolyzed ethylene-vinyl acetate copolymer, in which collagen is immobilized, is fine particles having an average particle size of 0.2 μm to 30 μm; and
wherein the dentin-regenerating pulp-capping agent contains 1 to 100 parts by weight of the hydrolyzed ethylene-vinyl acetate copolymer, in which collagen is immobilized, based on 100 parts by weight of the binder, and contains a boron compound in an amount of 0.001 to 0.1 part by weight converted to boron content based on 100 parts by weight of the hydrolyzed ethylene-vinyl acetate copolymer, in which collagen immobilized.
3. The dentin-regenerating pulp-capping agent of claim 2 , wherein the binder comprises a photo-curable monomer.
4. The dental material primer comprising a hydrolyzed ethylene-vinyl acetate copolymer in which collagen is immobilized, and a hydroxyl group-containing polymerizable monomer or an acidic group-containing polymerizable monomer as a primer component;
wherein the hydrolyzed ethylene-vinyl acetate copolymer, in which collagen is immobilized, is fine particles having an average particle size of 0.2 μm to 30 μm; and
wherein the dental material primer contains a boron compound in an amount of 0.001 to 0.1 part by weight converted to boron content based on 100 parts by weight of the hydrolyzed ethylene-vinyl acetate copolymer, in which collagen is immobilized.
5. A dentin-regenerating pulp-capping agent comprising a hydrolyzed ethylene-vinyl acetate copolymer in which collagen is immobilized, and a binder;
wherein the hydrolyzed ethylene-vinyl acetate copolymer, in which collagen is immobilized, is fine particles having an average particle size of 0.2 μm to 30 μm; and
wherein the dentin-regenerating pulp-capping agent contains a boron compound in an amount of 0.001 to 0.1 part by weight converted to boron content based on 100 parts by weight of the hydrolyzed ethylene-vinyl acetate copolymer, in which collagen immobilized.
6. A dentin-regenerating pulp-capping agent comprising a hydrolyzed ethylene-vinyl acetate copolymer in which collagen is immobilized, and a binder; and
wherein the dentin-regenerating pulp-capping agent contains a boron compound in an amount of 0.001 to 0.1 part by weight converted to boron content based on 100 parts by weight of the hydrolyzed ethylene-vinyl acetate copolymer, in which collagen immobilized.
7. A dental material primer comprising a hydrolyzed ethylene-vinyl acetate copolymer in which collagen is immobilized, and a hydroxyl group-containing polymerizable monomer or an acidic group-containing polymerizable monomer as a primer component;
wherein the primer has the property that when the primer is applied to a pulp exposed dental cavity, the primer regenerates dentin with no or hardly observable inflammation at dental pulp portions of the cavity; and
wherein the immobilization amount of collagen in the hydrolyzed ethylene-vinyl acetate copolymer is at least 5 μg·cm −2 and no more than about 40 μg·cm −2 .
8. A dentin-regenerating pulp-capping agent comprising a hydrolyzed ethylene-vinyl acetate copolymer in which collagen is immobilized, and a binder;
wherein the agent has the property that when the agent is applied to a pulp exposed dental cavity, the agent regenerates dentin with no or hardly observable inflammation at dental pulp portions of the cavity; and
wherein the immobilization amount of collagen in the hydrolyzed ethylene-vinyl acetate copolymer is at least 5 μg·cm −2 and no more than about 40 μg·cm −2 .