The invention refers to an improved vaccine against infections with pathogens, especially viral pathogens, comprising an antigen, a peptide of the formula R 1 —XZXZ N -XZX—R 2 and an immunostimulatory deoxynucleic acid containing deoxyinosine and/or deoxyuridine residues.
1. A vaccine for preventing infections with influenza virus comprising:
an influenza virus antigen;
a peptide (Peptide A) comprising a sequence KLKL 5 KLK (SEQ ID NO:6); and
an immunostimulatory oligodeoxynucleic acid molecule (I-/U-ODN), wherein the I-/U-ODN comprises oligo d(IC) 13 , I-ODN2, or I-ODN2b.
2. The vaccine of claim 1 , further comprising an Al(OH) 3 adjuvant.
3. The vaccine of claim 1 , wherein the influenza antigen is a haemagglutinin antigen or a neuraminidase antigen.
4. The vaccine of claim 1 , further comprising a polycationic peptide.
5. The vaccine of claim 1 , wherein the I/U-ODN is oligo d(IC) 13 .
6. The vaccine of claim 1 , further comprising an oligodeoxynucleotide containing a CpG-motif.
7. The vaccine of claim 1 , further comprising a polycationic peptide and an oligodeoxynucleotide containing a CpG-motif.
8. The vaccine of claim 1 , wherein the I/U-ODN is I-ODN2.
9. The vaccine of claim 1 , wherein the I/U-ODN is I-ODN2b.