IP Library › Granted Patent US 7,361,634
Granted Patent B2
US 7,361,634 · App. 10/554,375 · Granted Apr 22, 2008

Pain-sensitive therapeutic wound dressings

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Quick Facts
Patent No.
US 7,361,634
App. No.
10/554,375
Granted
Apr 22, 2008
Kind
B2
Abstract

The invention provides a wound dressing comprising a therapeutic agent and a matrix comprising polymers joined by cross-linkages which cross-linkages comprise oligopeptidic sequences which are cleavable by a kallikrein associated with wound fluid such that the rate of release of the therapeutic agent increases in the presence of elevated kallikrein levels.

Claims (10)

1. A wound dressing comprising a therapeutic agent and a matrix comprising polymers joined by cross-linkages which cross-linkages comprise oligopeptidic sequences which are cleavable by a kallikrein such that the rate of release of the therapeutic agent increases in the presence of the kallikrein, wherein the oligopeptide sequence comprises -Phe-Arg-Ser-Ser-Arg-Gln- (SEQ ID NO: 1) or -Met-Ile-Ser-Leu-Met-Lys-Arg-Pro-Gln- (SEQ ID NO: 2), wherein the polymer is a polymer of N-(2-hydroxypropyl) methyacrylamide (HPMA) and wherein the therapeutic agent is an antimicrobial agent, a pain relieving agent, an antiseptic, an analgesic, a local anaesthetic, or a kallikrein inhibitor.

2. A wound dressing according to claim 1 , wherein the therapeutic agent is incorporated within the matrix.

3. A wound dressing according to claim 2 , wherein the dressing further comprises a wound contacting layer wherein the wound contacting layer comprises the matrix within which the therapeutic agent is incorporated.

4. A wound dressing according to claim 2 , wherein the dressing comprises a liquid permeable wound contacting layer, an intermediate layer comprising the matrix within which the therapeutic agent is incorporated and an outer, liquid-impervious backing layer.

5. A wound dressing according to claim 1 , wherein the dressing comprises a barrier layer which comprises the matrix, the barrier layer being for initially separating the therapeutic agent in the wound dressing from wound fluid when in use.

6. A wound dressing according to claim 5 , wherein the barrier layer comprises an apertured sheet having a composition comprising the cross-linked polymers applied thereto in occlusive fashion.

7. A wound dressing according to claim 5 , wherein a layer of the therapeutic substance is provided behind the barrier layer.

8. A wound dressing according to claim 7 , wherein an absorbent layer is provided behind the barrier layer and the therapeutic substance is dispersed in the absorbent layer.

9. A wound dressing according to claim 8 , wherein the barrier layer substantially encapsulates the therapeutic substance.

10. A wound dressing according to claim 4 , wherein the wound dressing comprises an absorbent layer and/or a backing layer.

Assignments (13)
RELEASE OF SECURITY INTEREST IN PATENTS Recorded Nov 7, 2019
From: WILMINGTON TRUST, NATIONAL ASSOCIATION
To: KCI USA, INC.; KCI LICENSING, INC.
Reel/Frame 050966/0547 →
RELEASE OF SECURITY INTEREST IN PATENTS Recorded Nov 6, 2019
From: WILMINGTON TRUST, NATIONAL ASSOCIATION
To: KINETIC CONCEPTS, INC.; KCI USA, INC.; ACELITY L.P. INC.; CHIRON HOLDINGS, INC.; CHIRON TOPCO, INC.; KCI ANIMAL HEALTH, LLC; KCI HOLDING COMPANY, INC.; KCI HOMECARE, INC.; KCI IMPORTS, INC.; KCI INTERNATIONAL, INC.; KCI LICENSING, INC.; KCI PROPERTIES LIMITED; KCI REAL HOLDINGS, L.L.C.; KCI REAL PROPERTY LIMITED; KCI USA REAL HOLDINGS, L.L.C.; TECHNIMOTION, LLC
Reel/Frame 050945/0278 →
RELEASE OF SECURITY INTEREST Recorded Oct 11, 2019
From: BANK OF AMERICA, N.A.
To: KCI USA, INC.
Reel/Frame 050710/0955 →
RELEASE OF SECURITY INTEREST REEL/FRAME 040098/0268 Recorded Feb 8, 2017
From: WILMINGTON TRUST
To: KCI USA, INC.
Reel/Frame 041666/0320 →
SECURITY AGREEMENT Recorded Feb 7, 2017
From: KCI USA, INC., AS GRANTOR
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 041650/0013 →
RELEASE OF SECURITY INTEREST IN INTELLECTUAL PROPERTY Recorded Feb 6, 2017
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: KCI LICENSING, INC., AS GRANTOR; TECHNIMOTION, LLC, A DELAWARE LIMITED LIABILITY COMPANY, AS GRANTOR; SYSTAGENIX WOUND MANAGEMENT (US), INC., A DELAWARE CORPORATION, AS GRANTOR
Reel/Frame 041395/0044 →
LIMITED THIRD LIEN INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Oct 7, 2016
From: KCI USA, INC.; LIFECELL CORPORATION; KCI LICENSING, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 040291/0237 →
SECOND LIEN SECURITY AGREEMENT Recorded Sep 21, 2016
From: KCI USA, INC.; LIFECELL CORPORATION; KCI LICENSING, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 040098/0268 →
SECURITY INTEREST Recorded Feb 17, 2016
From: KINETIC CONCEPTS, INC.; KCI USA, INC.; ACELITY L.P. INC.; CHIRON HOLDINGS, INC.; CHIRON TOPCO, INC.; KCI ANIMAL HEALTH, LLC; KCI HOLDING COMPANY, INC.; KCI HOMECARE, INC.; KCI IMPORTS, INC.; KCI INTERNATIONAL, INC.; KCI LICENSING, INC.; KCI PROPERTIES LIMITED; KCI REAL HOLDINGS, L.L.C.; KCI REAL PROPERTY LIMITED; KCI USA REAL HOLDINGS, L.L.C.; LIFECELL CORPORATION; TECHNIMOTION, LLC
To: WILMINGTON TRUST, NATIONAL ASSOCIATION
Reel/Frame 037845/0497 →
MERGER AND CHANGE OF NAME Recorded May 11, 2015
From: SYSTAGENIX WOUND MANAGEMENT (US),INC.; KCI USA, INC.
To: KCI USA, INC.
Reel/Frame 035645/0178 →
MERGER AND CHANGE OF NAME Recorded Feb 11, 2015
From: SYSTAGENIX WOUND MANAGEMENT (US), INC.; KCI USA, INC.
To: KCI USA, INC.
Reel/Frame 034954/0870 →
SECURITY AGREEMENT Recorded Oct 29, 2013
From: SYSTAGENIX WOUND MANAGEMENT (US), INC.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 031508/0011 →
RELEASE OF SECURITY INTEREST Recorded Oct 28, 2013
From: J.P. MORGAN EUROPE LIMITED
To: SYSTAGENIX WOUND MANAGEMENT (US), INC.
Reel/Frame 031506/0186 →