Heterocyclic compounds
The present invention relates to the area of blood clotting. The invention relates in particular to certain heterocyclic compounds, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases.
1 . A compound of the formula (I)
in which
A is a group
where
*[N] is the point of attachment to the nitrogen,
*[C] is the point of attachment to the carbon, and
R 5 is hydrogen or alkyl,
M is an aryl, pyridyl, pyrimidyl pyridazinyl, thienyl, furyl or pyrrolyl radical which is unsubstituted or is substituted once or twice by radicals selected independently of one another from the group of halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro, carbamoyl, hydroxy, amino, alkylcarbonyl, alkoxycarbonyl, optionally alkylamino-substituted alkylaminocarbonyl, alkylcarbonyloxy, alkyl, alkylamino and alkoxy,
where
alkyl, alkylamino and alkoxy in turn may be substituted by amino, hydroxy, alkylamino, alkoxy, heterocyclyl or heterocyclylcarbonyl,
R 1 is an aryl, heteroaryl or heterocyclyl radical which is unsubstituted or is substituted once, twice or three times by radicals selected independently of one another from the group of halogen, optionally amino-substituted alkyl, amino, alkylamino, hydroxy, alkoxy, alkoxycarbonyl, alkylcarbonyl, alkylcarbonyloxy, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, nitro, oxo, carboxyl and cyano,
R 2 is an aryl, pyridyl, pyrimidyl or pyridazinyl radical,
which may be substituted by halogen, amino, alkylamino, alkylsulfonyl or alkyl-aminosulfonyl,
or
is an —N(R 6 )C(O)R 7 , —N(R 8 )C(O)NR 9 R 10 , —N(R 11 )S(O) x R 12 ,
or
—C(O)NR 15 R 6 radical,
where
R 6 , R 8 , R 11 , R 13 and R 15 are independently of one another hydrogen, alkyl or cycloalkyl,
where
alkyl and cycloalkyl may in turn be substituted by amino, hydroxy, alkylamino or alkoxy,
R 7 , R 9 , R 12 , R 14 and R 16 are independently of one another alkyl or cycloalkyl,
where
alkyl and cycloalkyl may in turn be substituted by amino, hydroxy, alkylamino or alkoxy,
or
R 6 and R 7 together with the N—C(O) group to which they are bonded form a 4- to 7-membered heterocycle which may also comprise one or two double bonds,
R 8 and R 9 together with the N—C(O)—N(R 10 ) group to which they are bonded form a 5- to 7-membered heterocycle,
R 10 is hydrogen, amino, hydroxy, alkylcarbonyl, alkylcarbonyloxy, alkoxycarbonyl, alkylaminocarbonyl, cycloalkyl, alkyl, alkylamino or alkoxy,
where
alkyl, alkylamino and alkoxy may in turn be substituted by amino, hydroxy, alkylamino, cycloalkylamino, alkoxy or heterocyclyl,
R 11 and R 12 together with the N—S(O) x group to which they are bonded form a 4- to 7-membered heterocycle which may also comprise one or two double bonds,
R 13 and R 14 together with the nitrogen to which they are bonded form a 4- to 7-membered heterocycle,
R 15 and R 16 together with the nitrogen to which they are bonded form a 4- to 7-membered heterocycle,
where the heterocycle formed by R 6 and R 7 ; R 8 and R 9 ; R 11 and R 12 ; R 13 and R 14 or by R 15 and R 16 comprises no, one, or two further heteroatoms from the series N, O and/or S and is unsubstituted or is substituted once, twice or three times by radicals independently of one another selected from the group of halogen, trifluoromethyl, cyano, nitro, amino, hydroxy, oxo, alkylcarbonyl, alkylcarbonyloxy, alkoxycarbonyl, alkylaminocarbonyl, alkyl, alkylamino and alkoxy,
where
alkyl, alkylamino and alkoxy may in turn be substituted by amino, hydroxy, alkylamino, alkoxy or heterocyclyl,
x is 1 or 2,
y is 0 or 1,
R 3 is hydrogen or alkyl,
R 4 is hydrogen, alkoxycarbonyl, alkylaminocarbonyl or alkyl,
where
alkyl in turn may be substituted by hydroxy, amino, alkoxy or alkylamino,
y is O or S
or a pharmaceutically acceptable salt thereof.
2 . The compound as claimed in claim 1 ,
in which
A is a group
where
*[N] is the point of attachment to the nitrogen,
*[C] is the point of attachment to the carbon, and
R 5 is hydrogen or methyl,
M is a phenyl or pyridyl radical which is optionally substituted once by fluorine, chlorine, trifluoromethyl, cyano, nitro, hydroxy, amino, acetyl, alkyl, alkylamino or alkoxy,
where
alkyl, alkylamino and alkoxy may in turn by substituted by amino, hydroxy, alkylamino, alkoxy or heterocyclyl,
R 1 is a phenyl, pyridyl, thienyl, furyl or pyrrolyl radical which is unsubstituted or is substituted once or twice by radicals selected independently of one another from the group of fluorine, chlorine, bromine, methyl, ethyl, aminomethyl, aminoethyl, amino, alkylamino, hydroxy, methoxy, acetyl, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, nitro and cyano,
R 2 is a phenyl or pyridyl radical, which may be substituted by fluorine, chlorine, amino or alkylaminio,
or
is an —N(R 6 )C(O)R 7 , —N(R 8 )C(O)NR 9 R 10 , —N(R 11 )S(O) x R 12 ,
or —C(O)NR 15 R 16 radical,
where
R 6 , R 7 , R 8 , R 9 , R 11 , R 12 , R 13 , R 14 , R 15 and R 16 are independently of one another methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, cyclopropyl or cyclopentyl,
each of which may in turn be substituted by amino, hydroxy, methoxy, ethoxy, methylamino, ethylamino, dimethylamino or diethylamino,
or
R 6 and R 7 together with the N—C(O) group to which they are bonded form a 5- or 6-membered heterocycle which may also comprise one or two double bonds,
R 8 and R 9 together with the N—C(O)—N(R 10 ) group to which they are bonded form a 5- or 6-membered heterocycle,
R 10 is hydrogen or alkyl,
where
alkyl may in turn be substituted by amino, hydroxy, alkylamino, cyclo-alkylamino, alkoxy or 5- or 6-membered heterocyclyl,
R 11 and R 12 together with the N—S(O), group to which they are bonded form a 5- or 6-membered heterocycle which may also comprise one or two double bonds,
R 13 and R 14 together with the nitrogen atom to which they are bonded form a 5- or 6-membered heterocycle,
R 15 and R 16 together with the nitrogen atom to which they are bonded form a 4- to 6-membered heterocycle,
where the heterocycle formed from R 6 and R 7 ; R 8 and R 9 ; R 11 and R 12 ; R 13 and R 14 or from R 15 and R 16 optionally comprises a further heteroatom from the series N, O and/or S and is unsubstituted or is substituted once or twice by radicals selected independently of one another from the group of amino, hydroxy, oxo, acetyl, alkoxycarbonyl, alkylaminocarbonyl, alkyl, alkylamino and alkoxy,
where
alkyl, alkylamino and alkoxy may in turn be substituted by amino, hydroxy, alkylamino, alkoxy or 5- or 6-membered heterocyclyl,
x is 2,
y is 0,
R 3 is hydrogen,
R 4 is hydrogen or alkyl,
where
alkyl may in turn be substituted by hydroxy, amino, alkoxy or alkylamino,
Y is O,
or a pharmaceutically acceptable salt thereof.
3 . The compound as claimed in claim 1 or 2 ,
in which
A is a group
where
*[N] is the point of attachment to the nitrogen,
*[C] is the point of attachment to the carbon,
M is phenyl which is optionally substituted once by fluorine, chlorine, tri-fluoromethyl, cyano, amino, methyl, ethyl, methylamino or dimethylamino,
where
methyl and ethyl may in turn be substituted by amino, hydroxy, methylamino, dimethylamino, methoxy, morpholinyl, piperazinyl, piperidinyl or pyrrolidinyl,
R 1 is thienyl which is substituted once by chlorine, bromine or methyl,
R 2 is a radical
where
this radical is unsubstituted or is substituted once or twice by radicals selected independently of one another from the group of amino, hydroxy, methoxy, methylamino and dimethylamino,
* is the point of attachment to M,
and
R 10 is hydrogen, methyl, ethyl or n-propyl,
where
ethyl and n-propyl may in turn be substituted by amino, hydroxy, methylamino, ethylamino, cyclopropylamino, isopropylamino, tert-butylamino, dimethylamino, diethylamino, methoxy, ethoxy, morpholinyl, piperazinyl, piperidinyl or pyrrolidinyl,
R 3 is hydrogen,
R 4 is hydrogen,
Y is O,
or a pharmaceutically acceptable salt thereof.
4 . A process for preparing compounds as defined in claim 1 , characterized in that either
(A) a compound of the formula (II)
in which
A, M, R 2 , R 3 and R 4 have the meanings indicated in claim 1 ,
is reacted with a compound of the formula (III)
in which
R 1 and Y have the meanings indicated in claim 1 , and
X 1 is chlorine or hydroxy,
or
(B) a compound of the formula (IV)
in which
M, R 1 , R 2 , R 3 , R 4 and Y have the meanings indicated in claim 1 , are reacted
(B1) with a compound of the formula (V)
in which
V is alkoxy or chlorine, and
X 2 is a leaving group,
or
(B2) with thionyl chloride (SOCl 2 )
or
(B3) with thionyl chloride (SOCl 2 ) and then with an oxidizing agent,
or
(B4) with N,N′-thiocarbonyldiimidazole
or
(C) a compound of the formula (VI)
in which
M, R 1 , R 2 , R 3 , R 4 , R 5 and Y have the meanings indicated in claim 1 , is reacted
(C1) with a carbonic acid equivalent,
or
(C2) with thionyl chloride (SOCl 2 )
or
(C3) with thionyl chloride (SOCl 2 ) and then with an oxidizing agent,
or
(C4) with N,N′-thiocarbonyldiimidazole,
and the resulting compound of the formula (I) is optionally reacted with an appropriate base or acid to give a pharmaceutically acceptable salt thereof.
5 . (canceled)
6 . A method for treating or preventing thromboembolic disorders, comprising administering to a patient a therapeutically effective amount of a compound of claim 1 .
7 . The method of claim 6 , wherein said therapeutically effective amount has anticoagulant activity.
8 . A method for preventing blood coagulation in vitro, characterized in that an amount having anticoagulant activity of a compound as defined in claim 1 is added.
9 . (canceled)
10 . A pharmaceutical composition comprising a compound as defined in claim 1 in combination with a pharmacologically acceptable excipient.
11 . The pharmaceutical composition of claim 10 , comprising a further active ingredient other than a compound as defined in claim 1 .
12 . The pharmaceutical composition of claim 10 , wherein the further active ingredient is selected from the group consisting of
lipid-lowering agents;
coronary therapeutics/vasodilators;
plasminogen activators (thrombolyticslfibrinolytics) and compounds which increase thrombolysis/fibrinolysis,
substances having anticoagulant activity (anticoagulants);
platelet aggregation-inhibiting substances (platelet aggregation inhibitors); and
fibrinogen receptor antagonists (glycoprotein IIb/IIIa antagonists).
13 . The pharmaceutical composition of claim 12 , wherein the lipid-lowering agent is a HMG-CoA (3-hydroxy-3-methylglutaryl-coenzym A) reductase inhibitor.
14 . The pharmaceutical composition of claim 12 , wherein the coronary therapeutic/vasodilator is an ACE (angiotensin converting enzyme) inhibitor; AII (angiotensin II) receptor antagonist; β-adrenoceptor-antagonist; alpha-1-adrenoceptor antagonist; diuretic; calcium channel blocker; or a substance which brings about an increase in cyclic guanosine monophosphate (cGMP).
15 . The pharmaceutical composition of claim 12 , wherein the plasminogen activators (thrombolytics/fibrinolytics) and compounds which increase thrombolysis/fibrinolysis are inhibitors of plasminogen activator inhibitor (PAI inhibitors) or inhibitors of thrombin-activated fibrinolysis inhibitor (TAFI).