Anti-inflammatory pharmaceutical compositions for reducing inflammation and the treatment or prevention of gastric toxicity
View Patent ↗The invention provides hops ( Humulus lupulus ) extracts or derivatives thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced, environmentally-induced, infection-induced, and/or stress-induced. The invention also provides a pharmaceutical composition comprising an active amount of hops extracts or derivatives thereof, in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of hops extracts or derivatives thereof, significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.
1. A composition comprising a compound selected from the group consisting of dihydro-isohumulone, dihydro-isocohumulone, dihydro-isoadhumulone, tetrahydro-isohumulone, tetrahydro-isocohumulone, tetrahydro-isoadhumulone, hexahydro-isohumulone, hexahydro-isocohumulone, and hexahydro-isoadhumulone; and a non-aspirin, non-steroidal anti-inflammatory compound, wherein the non-aspirin, non-steroidal anti-inflammatory compound is selected from the group consisting of salicylic acid, methyl salicylate, difulunisal, salsalate, olsalazine, sulfasalazine, acetanilids, acetaminophen, phenacetin, mefenamic acid, sodium meclofenamate, tolmetin, ketorolac, diclofenac, ibuprofen, naproxen, sodium daproxen, fenoprofen, ketoprofen, flurbioprofen, oxaprozin, piroxicam, meloxicam, tenoxicam, ampiroxicam, droxicam, pivoxicam, phenylbutazone, oxyphenbutazone, anitpyrine, aminopyrine, dipyrone, celecoxib, rofecoxib, nabumetone, apazone, nimensulide, indomethacin, sulindac, and etodolac, and wherein said composition reduces gastric toxicity from the non-aspirin, non-steroidal anti-inflammatory compound.
2. The composition of claim 1 , wherein the composition comprises about 0.5 to 10,000 mg of said compound.
3. The composition of claim 2 , wherein the composition comprises about 50 to 7,500 mg of the compound.
4. The composition of claim 1 , wherein the composition comprises about 0.001 to 10 weight percent of the compound.
5. The composition of claim 4 , wherein the composition comprises about 0.1 to 1 weight percent of the compound.
6. The composition of claim 1 , wherein the composition further comprises a pharmaceutically acceptable carrier.
7. The composition of claim 1 , wherein the composition is formulated for administration orally, topically, parenterally, or rectally.