Methods of treating cancer, arthritis and/or diabetes with angiopoietins
View Patent ↗The present invention relates to Angiopoietin-3 (Ang-3) and Angiopoietin-4 (Ang-4). The present invention also relates to methods of modulating an activity of Ang-3 or Ang-4. The present invention further relates to methods of treating cancer, diabetes, and arthritis.
1. A method of inhibiting angiogenesis, spontaneous metastasis or conversion from micrometastasis to macrometastsis in an individual who has cancer comprising the step of administering to said individual a therapeutically effective amount of a polypeptide comprising Angiopoietin-4 (SEQ ID NO: 4) to inhibit angiogenesis, spontaneous metastasis or conversion from micrometastasis to macrometastsis.
2. The method of claim 1 , wherein the individual has lung cancer or breast cancer.
3. The method of claim 1 , wherein the individual has small cell lung cancer.
4. A method of inhibiting angiogenesis in an individual who has arthritis or diabetes comprising the step of administering to said individual an effective amount of a polypeptide comprising Angiopoietin-4 (SEQ ID NO: 4) to inhibit angiogenesis.