8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

1. An 8-aza-bicyclo[3.2.1]octane derivative of the Formula I:

or any of its isomers or any mixture of its isomers,

or a pharmaceutically acceptable salt thereof,

wherein

R a represents hydrogen;

X represents —O—;

R b represents an aryl group selected from monosubstituted phenyl,

which group is substituted with a substituent selected from the group consisting of

trifluoromethoxy, cyano, hydroxy, and alkoxy; or

R b represents an aryl group selected from disubstituted phenyl which group is substituted with substituents independently selected from the group consisting of halo, trifluoromethyl, trifluoromethoxy, cyano, hydroxy, and alkoxy; or

R b represents a heteroaryl group selected from naphthyl, pyridyl, quinolinyl, isoquinolinyl or quinazolinyl, which heteroaryl group is substituted with one or two substituents independently selected from the group consisting of halo, trifluoromethyl, trifluoromethoxy, cyano, hydroxy, and alkoxy.

2. The chemical compound of claim 1 , wherein

R b represents a pyridyl group,

which pyridyl group is substituted with one or two substituents independently selected from the group consisting of:

halo, trifluoromethyl, trifluoromethoxy, cyano, hydroxy and alkoxy.

3. The chemical compound of claim 1 , which is

exo-3-(2,3-Dichlorophenoxy)-8-H-8-azabicyclo[3.2.1]octane;

exo-3-(3,4-Dichlorophenoxy)-8-H-8-azabicyclo[3.2.1]octane;

exo-3-(3-Chloro-4-fluorophenoxy)-8-H-8-azabicyclo[3.2.1]octane;

exo-3-(4-Chloro-3-fluorophenoxy)-8-H-8-azabicyclo[3.2.1]octane;

exo-3-(2-Chloro-3-trifluoromethyl-phenoxy)-8-H-8-azabicyclo[3.2.1]octane;

exo-3-(3,4-Dichlorophenoxy)-8-H-8-azabicyclo[3.2.1]octane;

exo-3-(4-Chloro-3-trifluoromethylphenoxy)-8-H-8-azabicyclo[3.2.1]octane;

exo-3-(3-Chloro-4-cyanophenoxy)-8-H-8-azabicyclo[3.2.1]octane;

exo-3-(4-Chloro-3-methylphenoxy)-8-H-8-azabicyclo[3.2.1]octane;

exo-3-(4-Chloronaphthalen-1-yloxy)-8-H-8-azabicyclo[3.2.1]octane;

exo-3-(5-Chloro-pyridin-2-yl)-8-H-8-azabicyclo[3.2.1]octane;

exo-3-(4-Methoxyphenoxy)-8-H-8-azabicyclo[3.2.1]octane;

exo-3-(6-Bromo-naphthalen-2-yloxy)-8-H-8-azabicyclo[3.2.1]octane;

exo-3-(4-Bromo-3-chloro-phenoxy)-8-H-8-azabicyclo[3.2.1]octane;

exo-3-(4-Cyanophenoxy)-8-H-8-azabicyclo[3.2.1]octane;

exo-3-(4-Methylphenoxy)-8-H-8-azabicyclo[3.2.1]octane;

exo-3-(6-Chloropyridin-2-yloxy)-8-H-8-azabicyclo[3.2.1]octane;

exo-3-(5-Bromopyridin-2-yloxy)-8-H-8-azabicyclo[3.2.1]octane;

exo-3-(6-Bromopyridin-2-yloxy)-8-H-8-azabicyclo[3.2.1]octane;

exo-3-(3-Trifluoromethoxyphenoxy)-8-H-8-azabicyclo[3.2.1]octane;

exo-3-(4-Trifluoromethoxyphenoxy)-8-H-8-azabicyclo[3.2.1]octane;

exo-3-(6-Methoxypyridin-2-yloxy)-8-H-8-azabicyclo[3.2.1]octane;

exo-3-(5-Trifluoromethylpyridin-2-yloxy)-8-H-8-azabicyclo[3.2.1]octane;

exo-3-(6-Ethoxypyridin-2-yloxy)-8-H-8-azabicyclo[3.2.1]octane;

exo-3-(4-Fluoro-3-trifluoromethylphenoxy)-8-H-8-azabicyclo[3.2.1]octane;

or any of its isomers or any mixture of its isomers, or a pharmaceutically acceptable salt thereof.

4. A pharmaceutical composition, comprising a therapeutically effective amount of a compound of claim 1 , or any of its isomers or any mixture of its isomers, or a pharmaceutically acceptable salt thereof, together with at least one pharmaceutically acceptable carrier, excipient or diluent.

5. The chemical compound of claim 1 , comprising:

exo-3-(3-Chloro-phenoxy)-8-H-8-azabicyclo[3.2.1]octane;

exo-3-(4-Chloro-phenoxy)-8-H-8-azabicyclo[3.2.1]octane;

or any of its isomers or any mixture of its isomers, or a pharmaceutically acceptable salt thereof.