Pharmaceutical composition
View Patent ↗The present invention provides pharmaceutical compositions, which are useful for treatment of depression and the like, and which comprises a compound having an adenosine A 2A receptor antagonistic activity such as (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione or a pharmaceutically acceptable salt thereof and an antidepressant drug (for example, a tricyclic antidepressant, a tetracyclic antidepressant, a selective serotonin reuptake inhibitor, a selective noradrenalin reuptake inhibitor, a dopamine reuptake inhibitor, a serotonin-noradrenalin reuptake inhibitor, a monoamine oxidase inhibitor, a 5-HT 2 antagonist or the like), and the like.
1. An orally administered pharmaceutical composition, comprising:
(a) (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione represented by the formula (I):
or a pharmaceutically acceptable salt thereof, and
(b) a selective serotonin reuptake inhibitor selected from the group consisting of paroxetine or a pharmaceutically acceptable salt and/or hydrate thereof, and fluoxetine or a pharmaceutically acceptable salt and/or hydrate thereof,
wherein a dose of said composition provides 0.0001-50 mg/kg of said (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione or said pharmaceutically acceptable salt thereof, and 0.001-1000 mg/kg of said serotonin reuptake inhibitor.
2. The pharmaceutical composition according to claim 1 , wherein the pharmaceutically acceptable salt of paroxetine or fluoxetine, is a hydrochloride.
3. The pharmaceutical composition according to claim 1 , wherein the selective serotonin reuptake inhibitor is fluoxetine hydrochloride, paroxetine hydrochloride, or paroxetine hydrochloride hydrate.
4. The pharmaceutical composition according to claim 1 , wherein a dose of said composition provides 0.001 to 30 mg/kg of said (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione, or said pharmaceutically acceptable salt thereof, and 0.005 to 1000 mg/kg of said serotonin reuptake inhibitor.
5. The pharmaceutical composition according to claim 4 , wherein the pharmaceutically acceptable salt of paroxetine or fluoxetine, is a hydrochloride.
6. The pharmaceutical composition according to claim 4 , wherein the serotonin reuptake inhibitor is fluoxetine hydrochloride, paroxetine hydrochloride, or paroxetine hydrochloride hydrate.
7. The pharmaceutical composition according to claim 1 , wherein a dose of said composition provides 0.005 to 20 mg/kg of said (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione, or said pharmaceutically acceptable salt thereof, and 0.01 to 50 mg/kg of said serotonin reuptake inhibitor.
8. The pharmaceutical composition according to claim 7 , wherein the pharmaceutically acceptable salt of paroxetine or fluoxetine, is a hydrochloride.
9. The pharmaceutical composition according to claim 7 , wherein the serotonin reuptake inhibitor is fluoxetine hydrochloride, paroxetine hydrochloride, or paroxetine hydrochloride hydrate.