IP Library › Granted Patent US 7,365,225
Granted Patent B2
US 7,365,225 · App. 10/565,557 · Granted Apr 29, 2008

Aryl dicarboxamides

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Quick Facts
Patent No.
US 7,365,225
App. No.
10/565,557
Granted
Apr 29, 2008
Kind
B2
Abstract

The present invention is related to aryl dicarboxamides of formula (I) and use thereof for the treatment and/or prevention of obesity and/or metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type I and/or II, inadequate glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia, hypercholes-terolemia, polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of aryl dicarboxamides of formula (I) to modulate, notably to inhibit the activity of PTPs. A is an aminocarbonyl moiety; Cy is an aryl, heteroaryl, aryl-heteroaryl, heteroaryl-aryl, aryl-aryl, cycloalkyl or heterocycle group; n is either 0 or 1; R 1 and R 2 are independently from each other is selected from the group consisting of hydrogen or C 1 -C 6 -alkyl; R 4 and R 5 are each independently from each other selected from the group consisting of H, hydroxy, C 1 -C 6 alkyl, carboxy, C 1 -C 6 alkoxy, C 1 -C 3 alkyl carboxy, C 2 -C 3 alkenyl carboxy, C 2 -C 3 alkynyl carboxy, amino or R 4 and R 5 may form an unsaturated or saturated heterocyclic ring, whereby at least one of R 4 or R 5 is not a hydrogen or C 1 -C 6 alkyl

Claims (144)

1. A method of treating type II diabetes or obesity,

comprising administering to a subject in need of such treatment an effective amount of at least one member selected from the group consisting of an aryl dicarboxamide of formula (Ia), formula (Ib), and formula (Ic):

a geometrical isomer thereof, an optically active form thereof, and a pharmaceutically acceptable salt thereof, wherein:

A is an aminocarbonyl moiety of the formula—CO—NHR 6 , wherein R 6 is a phenyl group attached directly or through an alkylene group, a phenyl-phenoxy group or an octyl group;

Cy is a phenyl group or a thiazole-phenyl group;

n is either 0 or 1;

R 1 and R 2 are hydrogen;

R 3 is selected from the group consisting of: (i) an alkyl group optionally substituted with an amino group, and (ii) a cyclopentyl group, a cyclohexyl group, a phenyl group, or a pyridyl group, attached directly or through an alkylene group or an oxo group, and optionally substituted with a cyano group or a fluoromethyl group.

2. An aryl dicarboxamide according to any of formulae (Ia), (Ib) or (Ic):

wherein

A is an aminocarbonyl moiety of the formula—CO—NHR 6 wherein R 6 is a phenyl group attached directly or through an alkylene group, a phenyl-phenoxy group, or an octyl group;

Cy is a phenyl group or a thiazole-phenyl group;

n is either 0 or 1;

R 1 and R 2 are hydrogen;

R 3 is selected from the group consisting of: (i) an alkyl group optionally substituted with an amino group, and (ii) a cyclopentyl group, a cyclohexyl group, a phenyl group, or a pyridyl group, attached directly or through an alkylene group or an oxo group, and optionally substituted with a cyano group or a fluoromethyl group.

3. An aryl dicarboxamide according to formula (Ib) or (Ic):

wherein

A is an aminocarbonyl moiety of the formula—CO—NHR 6 wherein R 6 a phenyl group attached directly or through an alkylene group, a phenyl-phenoxy group, or an octyl group;

Cy is a phenyl group or a thiazolyl-phenyl group;

n is either 0 or 1;

R 1 and R 2 are hydrogen;

R 3 is selected from the group consisting of:(i) an alkyl group optionally substituted with an amino group, and (ii) a cyclopentyl group, a cyclohexyl group, a phenyl group, or a pyridyl group, attached directly or through an alkylene group or an oxo group, and optionally substituted with a cyano group or a fluoromethyl group.

4. An aryl dicarboxamide selected from the group consisting of:

5-[(3-cyclopentylpropanoyl)(4-{[(4-phenoxybenzyl)amino]carbonyl}benzyl)amino]-2-hydroxybenzoic acid;

5[(3-cyclopentylpropanoyl)(4-{[(4-phenoxybenzyl)amino]carbonyl}benzyl)amino]-2-hydroxybenzoic acid;

[4-({{[2-(4-{[(4-pentylbenzyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl]methyl}-[(2E)-3-phenylprop-2-enoyl[amino}methyl)phenoxy]acetic acid;

5(3-cyclopentylpropanoyl)(4-{[(4-pentylbenzyl)amino]carbonyl}benzyl)amino]-2-hydroxybenzoic acid;

2-hydroxy-5-{(4-{[(4-pentylbenzyl)amino]carbonyl}benzyl)[4-(trifluoromcthyl)-benzoyl]amino}benzoic acid;

2-hydroxy-5[[(4-{[(4-phenoxybenzyl)amino]carbonyl}-1,3-thiazol-2-yl)methyl](3-phenylpropanoyl)amino]benzoic acid;

5-{benzoyl[(4-{[(4-phenoxybenzyl)amino]carbonyl}-1,3-thiazol-2-yl)methyl]-amino}-2-hydroxybenzoic acid;

2-hydroxy-5-{[(4-{[(4-phenoxybenzyl)amino]carbonyl}-1,3-thiazol-2-yl)methyl][ -4 -(trifluoromethyl)benzoyl]amino}benzoic acid;

5-[(cyclohexylcarbonyl)(4-{[(4-phenoxybcnzyl)amino]carbonyl}benzyl)amino]-2-hydroxybenzoic acid;

2-hydroxy-5-[(4-{[(4-phenoxybenzyl)amino]carbonyl}benzyl)(3-phenylpropanoyl)-amino]benzoic acid;

5-[benzoyl(4-{[(4-phenoxybenzyl)amino]carbonyl}benzyl)amino]-2-hydroxybenzoic acid;

5-[acetyl(4-{[(4-phenoxybenzyl)amino]carbonyl}benzyl)amino]-2-hydroxybenzoic acid;

5-[(4-cyanobenzoyl)(4-{[(4-phenoxybenzyl)amino]carbonyl}benzyl)amino]-2-hydroxybenzoic acid;

2-hydroxy-5-[(phenoxyacctyl)(4-{[4-phenoxybenzyl)amino]carbonyl}benzyl)-amino]-benzoic acid;

2-hydroxy-5-{(4-{[4-phenoxybenzyl)amino]carbonyl}benzyl)[4-(trifluoromethyl)-benzoyl]amino}benzoic acid;

2-hydroxy-5-{(4-{[(4-phenoxybenzyl)amino]carbonyl}benzyl)[(2E)-3-phenylprop-2-enoy amino}benzoic acid;

5-[(N,N-dimethylglycyl)(4-{[(4-phenoxybenzyl)amino]carbonyl}benzyl)amino]-2-hydroxybenzoic acid;

2-hydroxy-5-[(3-methylbut-2-enoyl)(4-{[(4-phenoxybenzyl)amino]carbonyl}benzyl)-amino]benzoic acid;

2-hydroxy-5-{[{4-[(octylamino)carbonyl]benzyl}(phenoxyacetyl)amino]methyl}-benzoic acid;

2-hydroxy-5-({{4-[(octylamino)carbonyl]benzyl}[4-(trifluoromethyl)benzoyl]-amino}methyl)benzoic acid;

2-hydroxy-5-({{4-[(octylamino)carbonyl]benzyl}[(2E)-3-phenylprop-2-enoyl]-amino}methyl)benzoic acid;

5-{[(3-cyclopentylpropanoyl)(4-{[(4-pentylbenzyl)amino]carbonyl}benzyl)-amino]methyl}-2-hydroxybenzoic acid;

2-hydroxy-5-{[(4-{[(4-pentylbenzyl)amino]carbonyl}benzyl)(phenoxyacetyl)-amino]methyl}benzoic acid;

2-hydroxy-5-({(4-{[(4-pentylbenzyl)amino]carbonyl}benzyl)[4-(trifluoromethyl)-benzoyl]amino}methyl)bcnzoic acid;

2-hydroxy-5-{[(3-methylbut-2-enoyl)(4-{[(4-pentylbenzyl)amino]carbonyl}-bcnzyl)amino]methyl}benzoic acid;

5-{[(3-cyclopentylpropanoyl)(4-{[(4phenylbutyl)amino]carbonyl}benzyl)-amino]methyl}-2-hydroxybenzoic acid;

2-hydroxy-5-({[(4-{[(4-pentylbenzyl)amino]carbonyl}-1,3-thiazol-2-yl)methyl][(2E)-3-phenylprop-2-enoyl]amino}methyl)benzoic acid;

[4-({(4-{[(4-phenoxybenzyl)amino]carbonyl}benzyl)[4trifluoromethyl)benzoyl]-amino}methyl)phenoxy]acetic acid;

2-hydroxy-5-[4-{[(4-pentylbenzyl)amino]carbonyl}benzyl)(3-phenyipropanoyl)-amino]benzoic acid;

4[(3-cyclopentylpropanoyl)(4-{[(4-pentylbenzyl)amino]carbonyl}benzyl)amino]-2-hydroxybenzoic acid;

2-hydroxy-4-{(4-{[(4-pentylbenzyl)amino]carbonyl}benzyl)[4-(trifluoromethyl)-benzoyl]amino}benzoic acid;

2-hydroxy-5-[{[2-(4-{[(4-pentylbenzyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl]methyl}(phenoxyacetyl)amino]benzoic acid;

2-hydroxy-5-{{[2-(4-{[(4-pentylbenzyl)amino]carbonyl}phenyl)-1,3-thiazol-4yl]methyl}[4-(trifluoromethyl)benzoyl]amino}benzoic acid;

5-([(6-chloropyridin-3-yl)carbonyl]{[2-(4-{[(4-pentylbenzyl)amino]carbonyl}-phenyl) -1,3-thiazol-4-yl]methyl}amino)-2-hydroxybenzoic acid;

5-((4-cyanobenzoyl){[2-(4-{[(4-pentylbenzyl)amino]carbonyl)}phenyl)-1,3-thiazol-4-yl]methyl}amino)-2-hydroxybenzoic acid;

2-hydroxy-5-((3-methylbut-2-enoyl){[2-(4-{[(4-pentylbenzyl)amino]carbonyl}-phenyl) -1,3-thiazol-4-yl]methyl}amino)benzoic acid;

5-((3-cyclopentylpropanoyl){[2-(4-{[(4-phenoxybenzyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl]methyl}amino)-2-hydroxybenzoic acid;

2hydroxy-5-{{[2-(4{[(4phenoxybenzyl)amino]carbonyl}phenyl)-1,3-thiazol-4yl]methyl}[4(trifluoromethyl)benzoyl]amino}benzoic acid;

2-hydroxy-5-[{[2-(4-{[(4-phenoxybcnzyl)amino]carbonyl}phenyl) 1,3-thiazol-4-yl]methyl}(3-phenylpropanoyl)amino]benzoic acid;

5-(benzoyl{[2-(4-{[(4-phenoxybenzyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl]methyl}amino)-2-hydroxybenzoic acid;

[4-({{[2-(4-{[(4-pentylbenzyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl]methyl}[4-(trifluoromethyl) benzoyl]amino}methyl)phenoxy]acetic acid;

(4-{[{[2-(4-{[(4-pentylbenzyl)amino]carbonyl}phenyl)1,3-thiazol-4-yl]methyl}(3-phenylpropanoyl) amino]methyl}phenoxy)acetic acid;

[4-({{[2-(4-{[(4-phenylbutyl)amino]carbonyl}phenyl)1,3-thiazol-4-yl]methyl}[(trifluoromethyl)benzoyl]amino}methyl)phenoxy]acetic acid;

(4-{[{[2-(4-{[(4-phenylbutyl)amino]carbonyl}phenyl)1,3-thiazol-4-yl]methyl}[(3-phenylpropanoyl)amino]methyl}phenoxy)acetic acid;

[4-({{[2-(4-{[(4-phenylbutyl)amino]carbonyl}phenyl)1,3-thiazol-4-yl]methyl}[(2E)-3-phenylprop-2-enoyl]amino}methyl)phenoxy]acetic acid;

{4-[((N,N-dimethylglycyl){[2-(4-{[(4-phenylbutyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl]methyl}amino)methyl]phenoxy}acetic acid;

{4-[((cyclohexylcarbonyl){[2-(4-{[(4-phenylbutyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yI]methyl}amino)methyl]phenoxy}acetic acid;

{4-[((phenoxyacetyl){[2-(4-{[(4-phenoxybenzyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl]methyl}amino)methyl]phenoxy}acetic acid;

[4-({{[2-(4-{[(4-phenoxybenzyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl]methyl}[4-(trifluoromethyl)benzoyl]amino}methyl)phenoxy]acetic acid;

(4-{[{[2-(4-{[(4-phenoxybenzyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl]methyl}(3-phenylpropanoyl)amino]methyl}phenoxy)acetic acid;

{4-[((cyclohexylcarbonyl){[2-(4-{[(4-phenoxybenzyl)amino]carbonyl}phenyl)1,3-thiazol-4-yl]methyl}amino)methyl]phenoxy}acetic acid;

[4-({[(2-{4-[(octylamino)carbonyl]phenyl}-1,3-thiazol-4-yl)methyl][4-(trifluoromethyl)benzoyl]amino}methyl)phenoxy]acetic acid; and

(4-{[[(2-{4-[(octylamino)carbonyl]phenyl}-1,3-thiazol-4-yl)methyl](3-phenylpropanoyl)amino]methyl}phenoxy)acetic acid.

5. A pharmaceutical composition comprising at least one aryl dicarboxamide according to claim 3 and a pharmaceutically acceptable carrier, diluent, excipient, or combination thereof.

6. A pharmaceutical composition comprising at least one aryl dicarboxamide according to claim 2 and a pharmaceutically acceptable carrier, diluent, excipient, or combination thereof.

7. A method of preparing the aryi dicarboxainide of

wherein FG is A or a leaving group,

wherein:

A is an aminocarbonyl moiety of the formula—CO—NHR 6 , wherein R 6 is a phenyl group attached directly or through an alkylene group, a phenyl-phenoxy group, or an octyl group;

Cy is a phenyl group or a thiazole-phenyl group;

n is either 0 or 1;

R 1 and R 2 are hydrogen; and

R 3 is selected from the group consisting of: (:) an alkyl group optionally substituted with an amino group, and (ii) a cyclopentyl group, a cyclopentyl group, a phenyl group, or a pyridyl group, attached directly or through an alkylene group or an xox group, and optionally substituted with a cyano group or a fluoromethyl group.

8. A method of treating type II diabetes or obesity, comprising administering to a subject in need of such treatment an effective amount of at least one member selected from the group consisting of:

5-[(3-cyclopentylpropanoyl)(4-{[(4-phenoxybenzyl)amino]carbonyl}benzyl)amino[-2-hydroxybenzoic acid;

5-[(3-cyclopentylpropanoyl)(4-{[(4-phenoxybenzyl)amino]caxbonyl}benzyl)amino]-2-hydroxybenzoic acid;

[4-({{[2-{[4-{[(4-pentylbenzyl)amino]carbonyl}phenyl)-1,3-thiazol-4yl]methyl}-[(2E)-3-phenylprop-2-enoyl]amino}methyl)phenoxy]acetic acid;

5-[(3-cyclopentylpropanoyl)(4-{[(4-pentylbenzyl)amino]carbonyl}benzyl)amino]-2-hydroxybenzoic acid;

2-hydroxy-5-{(4-{[(4-pentylbenzyl)amino]carbonyl}benzyl)[4-(trifluoromethy)-benzoyl]amino}benzoic acid;

2-hydroxy-5-[[(4-{[(4-phenoxybenzyl)amino]carbonyl}-1,3-thiazol -2-yl) methyl](3-phenylpropanoyl)amino]benzoic acid;

5-{benzoyl[(4-{[(4-phenoxybenzyl)amino]carbonyl}-1,3,thiazol-2-yl)mathyl]-amino}-2-hydroxybenzoic acid;

2-hydroxy-5-{[(4-{[(4-phenoxybenzyl)amino]carbonyl}-1,3-thiazol-2-yl)methyl][4-(trifluoromethyl)benzoyl]amino}benzoic acid;

5-[(cyclohexylcaxbonyl)(4-{[(4-phenoxybenzyl)amino]caxbonyl}benzyl)amino]-2-hydroxybenzoic acid;

2-hydroxy-5-[(4-{[(4-phenoxybenzyl)amino]carbonyl}benzyl)(3-phenylpropanoyl)-amino]benzoic acid;

5-[benzoyl(4-}[(4-phenoxybenzyl)amino]carbonyl}benzyl)aminol]-2-hydroxybenzoic acid:

5-[acetyl(4-{[4-phenoxybenzyl)amino]carbonyl}benzyl)amino]-2-hydroxybenzoic acid;

5-[(4-cyanobenzoyl(4-{[(4-phenoxybenzyl)amino]carbonyl}benzyl)amino]-2-hydroxybenzoic acid;

2-hydroxy-5-[(phenoxyacetyl)(4-}[(4-phenoxybenzyl)amino]carbonyl}benzyl)-amino]-benzoic acid;

2-hydroxy-5-{(4-{[(4-phenoxybenzyl)amino]carbonyl}benzyl)[4-(trifluoromethyl)-benzoyl]amino}benzoic acid;

2-hydroxy-5-{(4-{[(4-phenoxybenzyl)amino]carbonyl}benzyl)[(2E)-3-phenylprop-2-enoyl]amino}benzoic acid;

5-(N,N-dimethylglycyl)(4-{[(4-phenoxybenzyl)amino]carbonyl}benzyl)amino]-2-hydroxybenzoic acid;

2-hydroxy-5-[(3-methylbut-2-enoyl)(4-{[(4-phenoxybenzyl)amino]carbonyl}benzyl-amino]benzoic acid;

2-hydxoxy-5-{[{4-[(octylamino)carbonyl]benzyl}(phenoxyacetyl)amino]methyl}-benzoic acid;

2-hydroxy-5-({{4-[(octylamino)carbonyl]benzyl}[4-(trifluoromethyl) benzoyl[-amino}methyl)benzoic acid;

2-hydroxy-5-({{(4-[(octyhamino)carbonyl]benzyl}[(2E)-3-phenylprop-2-enoyl]-amino}methyl)benzoic acid;

5-{[(3-cyclopentylpropanoyl)(4-{[(4-pentylbenzyl)amino]carbonyl}benzyl)-amino]methyl}-2-hydroxybenzoic acid;

2-hydxoxy-5-{[(4-{[(4-pentylbenzyl)amino]carbonyl}benzyl)(phenoxyacetyl)-amino]methyl}benzoic acid:

2-hydroxy-5-({(4-{[(4-pentylbenzyl)amino]caxbonyl}benzyl)[4trifluorometliyl)-benzoyl]amino}methyl)benzoic acid;

2-hydroxy-5-{[(3-methylbut-2-enoyl)(4-{[(4-pentylbenzyl)amino]carbonyl}-benzyl)amino]methyl)benzoic acid;

5-{[(3-cyclopentylpropanoyl)(4-{[(4-phenylbutyl)amino]carbonyl}benzyl)-amino]methyl}-2-hydxoxybenzoic add;

5{[(3-cyclopentylpropanoyl)(4-{[(4-phenylbutyl)amino]carbonyl}benzyl)-amino]methyl}-2hydroxybenzoic acid;

2-hydroxy-5-({[(4-{[(4pentylbenzyl)amino]carbonyl}-1,3-thiazol-2-yl)methyl][(2E)-3-phenylprop-2-enoyl]amino}methyl)benzoic acid;

[4-({(4-{[(4-phenoxybenzyl)amino]carbonyl}benzyl)[4-(trifluoromethyl)benzoyl]-amino}methyl)phenoxy]acetic acid;

2-hydroxy-5-[(4-{[(4-pentylbenzyl)amino]carbonyl}benzyl)(3-phenylpropanoyl)-amino]benzoic acid;

4-[(3-cyclopentylpropanoyl)(4-{[(4-pentylbenzyl)amino]carbonyl}benzyl)amino]-2-hydroxybenzoic acid;

2-hydroxy-4-{(4-{[(4-pentylbenzyl)amino]carbonyl}benzyl)[4-(trifluoromethyl)-benzoyl]amino}benzoic add;

2-hydroxy-5-[{[2-(4-{[(4-pentylbenzyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl](phenoxyacetyl)amino]benzoic acid;

2-hydxoxy-5-{{[2(4-{[(4-pentylbenzyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl]-(trifluorornethyl)benzayl]amino}benzoic acid;

5-([(6-chloropyridin-3-yl)caxbonyl]{[2-(4-{[(4-pentylbenzyl)amino]carbonyl}-phenyl) -1,3-thiazol-4-yl]methyl}amino)-2-hydroxybenzoic add;

5-((4-cyanobenzoyl){[2-(4-{[(4-pentylbenzyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl]methyl}amino)-2-hydroxybenzoic acid;

2-hydroxy-5-((3-methylbut-2-enoyl){[2-(4{[(4-pentylbenzyl)amino]carbonyl}-phenyl) -thiazol-4-yl]methyl)amino)benzoic acid;

5-((3-cyclopentylpropanoyl){[2-(4-{[(4-phenoxybenzyl)amino]carbonyl}phenyl)-1,3-thiazol -yl]methyl)amino)-2-hydroxybenzoic acid;

2-hydroxy-5-{{[2-(4-{[(4-phenoxybenzyl)amino]carbonyl)phenyl)-1,3-thiazol-4-yl]methyl}[4-(trifluoromethyl)benzoyl]amino}benzoic acid;

2-hydroxy-5-[{[2-(4-{[(4-phenoxybenzyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl]methyl)(3-phenylpropanoyl)amino]benzoic acid;

5-benzoyl{[2-(4-{[(4-phenoxybenzyl)amino]carbonyl)phenyl)-1,3-thiazol-4-yl]methyl}amino}-2-hydroxybenzoic acid;

4-({{[2-(4-{[(4-pentylbenzyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl]methyl}[4-(trifluoromethy)benzoyl]amino}methyl)phenoxy]acetic acid;

(4-{[{[2-(4-{[(4-pentylbenzyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl]methyl}(phenylpropanoyl)amino]methyl)phenoxy)acetic acid;

[4-({{[2-(4-{[(4-phenylbutyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl]methyl}[4-(trifluoromethyl)benzoyl]amino)methyl)phenoxy]acetic acid;

(4-{[{[2-(4-{[(4-phenylbutyl)amino]carbonyl)phenyl)-1,3-thiazol-4-yl]methyl}(3-phenylpropanol)amino]methyl}phenoxy)acetic acid;

4-({{[2-(4-{[(4-phenylbutyl)amino]carbonyl)phenyl)-1,3-thiazol-4-yl]methyl}[(2E)-3-phenylprop-2-enoyl]amino)methyl}phenoxy]acetic acid;

{4-[((N,N-dimethylglycyl){[2-(4-{[(4-phenylbutyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl]methyl}amino)methyl]phenoxy}acetic acid;

{4-[((cyclohexylcarbyonyl){[2-(4-{[(4-phenylbutyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl]methyl)amino)methyl]phenoxy}acetic acid;

{4-[((phenoxyacetyl){[2-(4-{[(4-phenoxybenzyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl]methyl}amino)methyl]phenoxy}acetic acid;

[4-({{[2-(4-{[(4-phenoxybenzyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl]methyl}[4-(trifluoromethyl)benzoyl]amino}methyl)phenoxy]acetic acid;

(4-{[{[2-(4-{[4-phenoxybenzyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl ]methyl}(3-phenylpropanoyl)amino]methyl)phenoxy)acetic acid;

{4-[((cyclohexylcarbonyl){[2-(4-{[(4-phenoxybenzyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl]methyl}amino)methyl}phenoxy}acetic acid;

[4-({[(2-{4-[(octylamino)carbonyl]phenyl}-1,3-thiazol-4-yl)methyl][4-(trifluoromethyl)benzoyl]amino}methyl)phenoxy]acetic acid; and

(4-{[[(2-{4-[(octylamino)carbonyl]phenyl}-1,3-thiazol-4-yl)methyl](3-phenylpropanoyl amino}methyl}phenoxy)acetic acid;

or a geometrical isomer thereof;

an optically active form thereof; or

a pharmaceutically acceptable salt thereof.

Assignments (3)
CHANGE OF NAME Recorded Dec 3, 2009
From: LABORATOIRES SERONO SA
To: MERCK SERONO SA
Reel/Frame 023599/0944 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 15, 2007
From: THOMAS, RUSSELL J.; SWINNEN, DOMINIQUE; PONS, JEAN FRANCOIS; BOMBRUN, AGNES
To: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
Reel/Frame 019964/0564 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 11, 2007
From: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
To: LABORATOIRES SERONO SA
Reel/Frame 019966/0026 →