Reduced-exposure tobacco products
View Patent ↗The present invention provides methodologies, including the utilization of genetically modified (GM) tobaccos, for the development and production of consumer acceptable PREPs encompassing the following: 1) production of low tar-to-nicotine ratio cigarettes, which allow smokers to obtain satisfying amounts of nicotine more efficiently than conventional cigarettes while reducing whole smoke deliveries; thereby reducing smoker “compensation” that exists with conventional low-yield cigarettes; 2) reduction of harmful tobacco-specific nitrosamines in tobacco products by genetic means and by extracting nicotine from tobacco and combining such with genetically modified reduced-nicotine tobacco; 3) production of improved expanded tobacco which utilizes genetically modified increased-nicotine tobacco; and 4) production of reconstituted tobacco which includes any combinations of the following: genetically modified increased-nicotine tobacco, genetically modified reduced-nicotine tobacco, tobacco leaf fractions, and freshly harvested freeze-dried tobacco.
1. A cigarette comprising a portion of an increased-nicotine transgenic Nicotiana tabacum plant, wherein said cigarette is characterized by (i) a tar-to-nicotine yield ratio of between about 3 and about 8, as measured by the FTC or ISO method, (ii) a filler that is not all reconstituted tobacco, and (iii) cigarette smoke having a pH of about 6.5 or lower.
2. A cigarette according to claim 1 , wherein said plant expresses at least one heterologous nucleic acid that up-regulates the production of nicotine in said transgenic plant or plant portion.
3. A cigarette according to claim 2 , wherein said plant expresses a heterologous nucleic acid encoding at least a segment of QPT and PMT.