Treatment of endometriosis
View Patent ↗A method of combating menorrhagia, dysmenorrhoea or endometriosis in a female individual that includes administering to the individual at least one agent that reduces the effect of prokineticin 1 on a prokineticin receptor.
1. A method of treating endometriosis in a female individual, the method comprising administering to the individual at least one agent that reduces the effect of prokineticin 1 (PK1) on a prokineticin receptor (PKR),
wherein the agent that reduces the effect of PK1 on a PKR is an anti-PK1 antibody.
2. A method of treating endometriosis according to claim 1 further comprising administering to the individual at least one agent which lowers estrogen levels or which antagonises the estrogen receptor.
3. A method according to claim 2 wherein the at least one agent which lowers estrogen levels or which antagonises the estrogen receptor is a gonadotropin releasing hormone (GnRH) antagonist.
4. A method according to claim 3 wherein the GnRH antagonist is teverelix, abarelix, cetrorelix or ganirelix.
5. A method according to claim 1 wherein the anti-PK1 antibody is selected from 1C6, 2A3, 2A8 and 4H9.