Neuroprotective bicyclic compounds and methods for their use
View Patent ↗Embodiments of this invention provide novel cyclic compounds structurally related to diketopiperazines and methods for their therapeutic use. Such compounds are neuroprotective and have utility as therapeutic agents for treatment of diseases, injuries and other conditions characterized by neuronal degeneration and/or death. Compounds are also useful for manufacture of medicaments useful for treatment of such conditions.
1. A compound having the formula:
or a pharmaceutically acceptable salt or thereof, where
X 1 is NH;
X 2 is CH 2 ;
R 1 is allyl,
R 2 , and R 3 are independently selected from the group consisting of —H, —OR′, —SR′, —NR′R′, —NO 2 , —CN, —C(O)OR′, —C(O)NR′R′, —C(NR′)NR′R′, trihalomethyl, halogen, alkyl, heteroalkyl, alkenyl, alkynyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl; each R′ is independently selected from the group consisting of —H, alkyl, heteroalkyl, alkenyl, alkynyl, aryl, arylalkyl, heteroaryl and heteroarylalkyl;
R 4 and R 5 are H;
and optionally, wherein R 2 and R 3 taken together are —CH 2 —(CH 2 ) n —CH 2 — where n is an integer from 0-6.
2. The compound of claim 1 where, R 2 =R 3 =H.
3. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable excipient.