Liquid formulations of ractopamine
View Patent ↗Described is a soluble stable liquid formulation, process for preparing, and a method of using the soluble stable liquid formulation comprising ractopamine or a physiologically acceptable salt thereof, a liquid nonionic cosolvent, and water.
1. A solubilized stabilized liquid formulation comprising from 10 to 30% w/w of ractopamine or a physiologically acceptable salt thereof; from 20 to 90% w/w of a liquid nonionic cosolvent selected from polyethoxylated sorbitan fatty acid esters, polyethoxylated vegetables oils, or both; and 5 to 75% w/w water.
2. The solubilized stabilized liquid formulation of claim 1 comprising 10 to 20% w/w ractopamine or a physiologically acceptable salt thereof, 30 to 80% w/w of a liquid nonionic cosolvent selected from polyethoxylated sorbitan fatty acid esters, polyethoxylated vegetable oils or both, and 10 to 60% w/w water.
3. The solubilized stabilized liquid formulation of claim 1 comprising 10 to 15% ractopamine or a physiologically acceptable salt thereof; from 40 to 55% liquid nonionic cosolvent selected from polyethoxylated sorbitan fatty acid esters, polyethoxylated vegetable oils, or both; and 35 to 50% water.
4. The solubilized stabilized liquid formulation of claim 3 wherein the nonionic cosolvent is a polyethoxylated sorbitan fatty acid ester.
5. The solubilized stabilized liquid formulation of claim 3 wherein the nonionic cosolvent is a polyethoxylated vegetable oil.
6. The solubilized stabilized liquid formulation of claim 4 wherein the nonionic cosolvent is polyoxythylene 20 sorbitan monolaurate.
7. The solubilized stabilized liquid formulation of claim 6 wherein ractopamine or a physiologically acceptable salt thereof is ractopamine hydrochloride.
8. A process for preparing a solubilized stabilized liquid formulation comprising:
admixing ractopamine or a physiologically acceptable salt thereof with water and a liquid nonionic cosolvent selected from polyethoxylated sorbitan fatty acid esters, polyethoxylated vegetable oils, or both; and heating the mixture to no higher than 100° C. to afford a stabilized and solubilized formulation comprising from 10 to 30% w/w ractopamine or a physiologically acceptable salt thereof; from 20 to 90% w/w of a liquid nonionic cosolvent selected from polyethoxylated sorbitan fatty acid esters, polyethoxylated vegetable oils, or both; and, from 5 to 75% w/w water.
9. A method of increasing weight gain, improving the efficiency of feed utilization, increasing leanness, decreasing lipogenesis, increasing lipolysis, increasing muscle protein synthesis, decreasing muscle protein breakdown, or an improvement in carcass quality of a ruminant, a swine or a turkey comprising administering to the ruminant, swine or turkey an effective amount of a solubilized stabilized liquid formulation of claim 1 .