Benzimidazole Acetonitriles

1 . A benzimidazole acetonitrile according to formula (I)

as well as its tautomers, its geometrical isomers, its optically active forms as enantiomers, diastereomers and its racemate forms, as well as pharmaceutically acceptable salts thereof, wherein

G is a pyrimidinyl;

L is an amino group, or a 3-8 membered heterocycloalkyl, containing at least one heteroatom selected from N, O, S or L is an acylamino moiety;

R 1 is selected from the group comprising or consisting of hydrogen, sulfonyl, amino, carboxy, amino carbonyl, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl or C 1 -C 6 -alkoxy, aryl, halogen, cyano or hydroxy;

R 2 is selected from the group comprising or consisting of hydrogen, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, or C 1 -C 6 -alkoxy.

2 . The benzimidazole acetonitrile according to claim 1 , wherein R 1 is H or C 1 -C 3 alkyl.

3 . The benzimidazole acetonitrile according to claim 1 , wherein R 2 is a C 1 -C 3 alkyl.

4 . The benzimidazole acetonitrile according to claim 1 , having any of the formulae

wherein R 1 is as above defined, and

R 3 is selected from the group comprising or consisting of hydrogen, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, or C 1 -C 6 -alkoxy;

L is an amino group of the formula —NR 5 R 6 wherein R 5 and R 6 are each independently from each other H, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 1 -C 6 -alkoxy, aryl, heteroaryl, saturated or unsaturated 3-8-membered cycloalkyl, 3-8-membered heterocycloalkyl, C 1 -C 6 -alkyl aryl, C 1 -C 6 -alkyl heteroaryl, C 1 -C 6 -alkenyl aryl, C 1 -C 6 -alkenyl heteroaryl, C 1 -C 6 -alkynyl aryl, C 1 -C 6 -alkynyl heteroaryl, C 1 -C 6 -alkyl cycloalkyl, C 1 -C 6 -alkyl heterocycloalkyl, C 1 -C 6 -alkenyl cycloalkyl, C 1 -C 6 -alkenyl heterocycloalkyl, C 1 -C 6 -alkynyl cycloalkyl, C 1 -C 6 -alkynyl heterocycloalkyl, or

R 5 and R 6 may form a ring together with the nitrogen to which they are bound.

5 . The benzimidazole acetonitrile according to claim 1 , wherein R 5 is hydrogen or a methyl or ethyl or propyl group and R 6 is a selected from the group consisting of H, (C 1 -C 10 )-alkyl, C 1 -C 6 alkyl-aryl, C 1 -C 6 -alkyl-heteroaryl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl and 4-8 membered saturated or unsaturated cycloalkyl.

6 . The benzimidazole acetonitrile according to claim 1 , wherein R 5 is H and R 6 is selected from the group consisting of C 1 -C 6 alkyl, 3-8 membered cycloalkyl, 3-8 membered heterocycloalkyl, heteroaryl, C 1 -C 6 -alkyl heteroaryl, C 1 -C 6 -alkyl cycloalkyl, C 1 -C 6 -alkyl heterocycloalkyl.

7 . The benzoxazole acetonitrile according to claim 1 , wherein L is an acylamino moiety of the formula —NR 5 C(O)R 6 wherein R 5 and R 6 are each independently from each other H, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 1 -C 6 -alkoxy, aryl, heteroaryl, saturated or unsaturated 3-8-membered cycloalkyl, 3-8-membered heterocycloalkyl, C 1 -C 6 -alkyl aryl, C 1 -C 6 -alkyl heteroaryl, C 1 -C 6 -alkenyl aryl, C 1 -C 6 -alkenyl heteroaryl, C 1 -C 6 -alkynyl aryl, C 1 -C 6 -alkynyl heteroaryl, C 1 -C 6 -alkyl cycloalkyl, C, -C 6 -alkyl heterocycloalkyl, C 1 -C 6 -alkenyl cycloalkyl, C 1 -C 6 -alkenyl heterocycloalkyl, C 1 -C 6 -alkynyl cycloalkyl, C 1 -C 6 -alkynyl heterocycloalkyl.

8 . The benzimidazole acetonitrile according to claim 1 selected from the group consisting of:

(2Z)-(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)(2-{[3-(1H-pyrazol-1-yl)propyl]amino}pyrimidin-4-yl)acetonitrile

(2Z)-(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)(5-methyl-2-{[3-(1H-pyrazol-1-yl)propyl]amino}pyrimidin-4-yl)acetonitrile

(2Z)-[2-(cyclobutylamino)-5-methylpyrimidin-4-yl](1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)acetonitrile

(2Z)-(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)(5-methyl-2-{[3-(2-oxopyrrolidin-1-yl)propyl]amino}pyrimidin-4-yl)acetonitrile

(2Z)-(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)(2-{[3-(2-oxopyrrolidin-1-yl)propyl]amino}pyrimidin-4-yl)acetonitrile

(2Z)-(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)(2-{[3-(1H-1,2,4-triazol-1-yl)propyl]amino}pyrimidin-4-yl)acetonitrile

(2Z)-(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)(5-methyl-2-{[3-(1H-1,2,4-triazol-1-yl)propyl]amino}pyrimidin-4-yl)acetonitrile

[2-(cyclopentylamino)-5-methylpyrimidin-4-yl](1-ethyl-1H-benzimidazol-2-yl)acetonitrile

(2Z)-(2-{[3-(2-oxopyrrolidin-1-yl)propyl]amino}pyrimidin-4-yl)(1-propyl-1,3-dihydro-2H-benzimidazol-2-ylidene)acetonitrile

(1-ethyl-1H-benzimidazol-2-yl){5-methyl-2-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}acetonitrile

(2Z)-[2-(cyclobutylamino)pyrimidin-4-yl](1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)acetonitrile

(2Z)-[2-(cycloheptylamino)-5-methylpyrimidin-4-yl](1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)acetonitrile

[2-(cyclopentylamino)pyrimidin-4-yl](1-ethyl-1H-benzimidazol-2-yl)acetonitrile

1,3-dihydro-2H-benzimidazol-2-ylidene(5-methyl-2-{[3-(2-oxopyrrolidin-1-yl)propyl]amino}pyrimidin-4-yl)acetonitrile

(2Z)-(1-cyclobutyl-1,3-dihydro-2H-benzimidazol-2-ylidene)(2-{[3-(2-oxopyrrolidin-1-yl)propyl]amino}pyrimidin-4-yl)acetonitrile

(1-ethyl-1H-benzimidazol-2-yl){2-[(2-pyridin-3-yl-ethyl)amino]pyrimidin-4-yl}acetonitrile

(2Z)-(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)[2-(isobutylamino)-5-methylpyrimidin-4-yl]acetonitrile

(2Z)-(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)(2-{[2-(1H-imidazol-4-yl)ethyl]amino}pyrimidin-4-yl)acetonitrile

(2Z)-(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)[2-(isobutylamino)pyrimidin-4-yl]acetonitrile

[2-(cyclopropylamino)pyrimidin-4-yl](1-ethyl-1H-benzimidazol-2-yl)acetonitrile

[2-({2-[6-(dimethylamino)pyridin-3-yl]ethyl}amino)pyrimidin-4-yl](1-ethyl-1H-benzimidazol-2-yl)acetonitrile

(1-ethyl-1H-benzimidazol-2-yl)(2-{[2-(1H-1,2,4-triazol-1-yl)ethyl]amino}pyrimidin-4-yl)acetonitrile

(2Z)-(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)(2-{[2-(1H-imidazol-4-yl)ethyl]amino}-5-methylpyrimidin-4-yl)acetonitrile

[2-({2-[6-(dimethylamino)pyridin-3-yl]ethyl}amino)-5-methylpyrimidin-4-yl](1-ethyl-1H-benzimidazol-2-yl)acetonitrile

(2Z)-[2-(cycloheptylamino)pyrimidin-4-yl](1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)acetonitrile

[2-(cyclopropylamino)-5-methylpyrimidin-4-yl](1-ethyl-1H-benzimidazol-2-yl)acetonitrile

(1-ethyl-1H-benzimidazol-2-yl){2-[(2-pyridin-2-ylethyl)amino]pyrimidin-4-yl}acetonitrile

[2-(cyclopentylamino)-5-methylpyrimidin-4-yl](1,3-dihydro-2H-benzimidazol-2-ylidene)acetonitrile

[2-(cyclohexylamino)pyrimidin-4-yl](1-ethyl-1H-benzimidazol-2-yl)acetonitrile

(2Z)-(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)(2-{[2-(1H-indol-3-yl)ethyl]amino}-5-methylpyrimidin-4-yl)acetonitrile

(1-ethyl-1H-benzimidazol-2-yl){5-methyl-2-[(2-pyridin-2-ylethyl)amino]pyrimidin-4-yl}acetonitrile

{2-[(2-ethoxyethyl)amino]pyrimidin-4-yl}(1-ethyl-1H-benzimidazol-2-yl)acetonitrile

(1-ethyl-1H-benzimidazol-2-yl){5-methyl-2-[(1-methylbutyl)amino]pyrimidin-4-yl}acetonitrile

(1-ethyl-1H-benzimidazol-2-yl)[2-(methylamino)pyrimidin-4-yl]acetonitrile

(1-ethyl-1H-benzimidazol-2-yl)(5-methyl-2-{[2-(1H-pyrazol-1-yl)ethyl]amino}pyrimidin-4-yl)acetonitrile

1H-benzimidazol-2-yl{5-methyl-2-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}acetonitrile

(2Z)-(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)(2-{[2-(1H-imidazol-1-yl)ethyl]amino}-5-methylpyrimidin-4-yl)acetonitrile

1H-benzimidazol-2-yl{2-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}acetonitrile

(1-ethyl-1H-benzimidazol-2-yl){2-[(1-methylbutyl)amino]pyrimidin-4-yl}acetonitrile

{2-[(cyclohexylmethyl)amino]-5-methylpyrimidin-4-yl}(1-ethyl-1H-benzimidazol-2-yl)acetonitrile

1H-benzimidazol-2-yl[2-(cyclopentylamino)pyrimidin-4-yl]acetonitrile

(1-ethyl-1H-benzimidazol-2-yl){6-methyl-2-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}acetonitrile

1H-benzimidazol-2-yl[2-(cyclopropylamino)pyrimidin-4-yl]acetonitrile

[2-(cyclopentylamino)-6-methylpyrimidin-4-yl](1-ethyl-1H-benzimidazol-2-yl)acetonitrile

{2-[(cyclohexylmethyl)amino]pyrimidin-4-yl}(1-ethyl-1H-benzimidazol-2-yl)acetonitrile

(1-ethyl-1H-benzimidazol-2-yl){6-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}acetonitrile

(1-ethyl-1H-benzimidazol-2-yl){2-[(3-pyrrolidin-1-ylpropyl)amino]pyrimidin-4-yl}acetonitrile

(1-ethyl-1H-benzimidazol-2-yl)[2-(4-ethylpiperazin-1-yl)-5-methylpyrimidin-4-yl]acetonitrile

(1-ethyl-1H-benzimidazol-2-yl){2-[(2-furylmethyl)amino]-5-methylpyrimidin-4-yl}acetonitrile

(2Z)-(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene){5-methyl-2-[(1-methylpiperidin-4-yl)amino]pyrimidin-4-yl}acetonitrile

(2Z)-[2-(cyclohexylamino)-5-methylpyrimidin-4-yl](1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)acetonitrile

(2Z)-[2-(ethylamino)-5-methylpyrimidin-4-yl](1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)acetonitrile

[2-(cyclopentylamino)-5-methylpyrimidin-4-yl](1,3-diethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)acetonitrile

(2Z)-(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)[5-methyl-2-(piperidin-4-ylamino)pyrimidin-4-yl]acetonitrile

(2Z)-(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene){5-methyl-2-[(2-piperidin-1-ylethyl)amino]pyrimidin-4-yl}acetonitrile

N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}-4-(4-methylpiperazin-1-yl)-4-oxobutanamide

N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]pyrimidin-2-yl}-4-(4-methylpiperazin-1-yl)-4-oxobutanamide

(1R,5R,7R)-N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}-6,8-dioxa-3-azabicyclo[3.2.1 ]octane-7-carboxamide

(1S,5S,7S)-N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-carboxamide

(1S,4S,5S,7R)-N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}-4-methyl-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-carboxamide

(1S ,4R,5 S,7R)-N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}-4-methyl-6,8-dioxa-3-azabicyclo[3.2.1 ]octane-7-carboxamide

N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}piperazine-2-carboxamide

(4S)-N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}-1,3-thiazolidine-4-carboxamide

(4R)-N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}-1,3-thiazolidine-4-carboxamide

N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl)-5-oxo-L-prolinamide

4-tert butyl 1-(9H-fluoren-9-ylmethyl)2-[({4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}amino)carbonyl]piperazine-1,4-dicarboxylate

tert-butyl (4S)-4-[({4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}amino)carbonyl]-1,3-thiazolidine-3-carboxylate

tert-butyl (2S)-2-[({4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl }amino)carbonyl]-5-oxopyrrolidine-1-carboxylate

tert-butyl (4R)-4-[({4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}amino)carbonyl]-1,3-thiazolidine-3-carboxylate

2-(1-acetylpiperidin-4-yl)-N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}acetamide

N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}-4-methylmorpholine-2-carboxamide

4-acetyl-N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}morpholine-2-carboxamide

N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}-4-[(4-methylpiperazin-1-yl)methyl]benzamide

tert-butyl 3-[({4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}amino)carbonyl]piperidine-1-carboxylate

tert butyl 4-[2-({4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}amino)-2-oxoethyl]piperidine-1-carboxylate

N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}morpholine-2-carboxamide

N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}-2-piperidin-4-ylacetamide

N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}piperidine-3-carboxamide

tert-butyl 2-[({4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}amino)carbonyl]morpholine-4-carboxylate

N-[3-({4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}amino)-3-oxopropyl]benzamide

tert-butyl [2-({4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}amino)-2-oxoethyl]methylcarbamate

N-(4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}-1-methylpiperidine-3-carboxamide

N˜1˜-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}-N˜2˜-methylglycinamide

N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}pyrrolidine-3-carboxamide

tert-butyl 3-[({4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}amino)carbonyl]pyrrolidine-1-carboxylate

(2S)-N-(4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl)-2,5-dihydro-1H-pyrrole-2-carboxamide

tert-butyl (2S)-2-[({4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}amino)carbonyl]-2,5-dihydro-1H-pyrrole-1-carboxylate

N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}-2-(2-methoxyphenyl)acetamide

1-acetyl-N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}piperidine-4-carboxamide

N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}-1-methylpiperidine-4-carboxamide

4-amino-N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}butanamide

tert-butyl 4-[({4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}amino)carbonyl]piperidine-1-carboxylate

N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}piperidine-4-carboxamide

tert-butyl [4-({4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}amino)-4-oxobutyl]carbamate

N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}cyclopentanecarboxamide

N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl)-4-(4-methylpiperazin-1-yl)butanamide

N˜1˜-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}-N˜3˜,N˜3˜-dimethyl-beta-alaninamide

N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}-4-(dimethylamino)butanamide

(2Z)-(2-amino-5-methylpyrimidin-4-yl)(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)acetonitrile

N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-yliene)methyl]-5-methylpyrimidin-2-yl}-2-morpholin-4-ylacetamide

N˜2˜-benzyl-N˜1˜-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}glycinamide

N-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}-2-(1,1-dioxidothiomorpholin-4-yl)acetamide

N˜1˜-{4-[(Z)-cyano(1-ethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)methyl]-5-methylpyrimidin-2-yl}-N˜2˜-formylglycinamide.

9 . A benzimidazole acetonitrile according to claim 1 for the preparation of a medicament.

10 . A benzimidazole acetonitrile according to claim 1 in the preparation of a medicament for the prevention and/or treatment of metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type II, inadequate glucose tolerance, insulin resistance, obesity, polycystic ovary syndrome (PCOS).

11 . The benzimidazole acetonitrile according to claim 9 wherein the disease is diabetes type II.

12 . A pharmaceutical composition containing a benzimidazole acetonitrile according to claim 1 and a pharmaceutically acceptable carrier, diluent or excipient thereof.

13 . The composition according to claim 12 , further comprising at least one supplementary drug selected from the group consisting of insulin, aldose reductase inhibitors, alpha-glucosidase inhibitors, sulfonyl urea agents, biguanides, thiazolidines, PPARs agonists, GSK-3 inhibitors.

14 . The composition according to claim 13 wherein said supplementary drug is selected from the group consisting of a rapid acting insulin, an intermediate acting insulin, a long acting insulin, a combination of intermediate and rapid acting insulins, Minalrestat, Tolrestat, Sorbinil, Methosorbinil, Zopolrestat, Epalrestat, Zenarestat, Imirestat, Ponalrestat, ONO-2235, GP-1447, CT-112, BAL-ARI 8, AD-5467, ZD5522, M-16209, NZ-314, M-79175, SPR-210, ADN 138, or SNK-860, Miglitol, Acarbose, Glipizide, Glyburide, Chlorpropamide, Tolbutamide, Tolazamide, or Glimepriride.

15 . A method of preparing a benzimidazole acetonitrile of formula (I) according to claim 1 , comprising the following step:

wherein R 1 , R 2 ,G, L are as above described.

16 . A method of preparing a benzimidazole acetonitrile of formula (I) according to claim 1 , comprising the following step:

17 . A method according to claim 15 , comprising the following steps:

wherein R 1 , R 3 and R 4 are as above defined.

17 . (canceled)

18 . (canceled)

19 . The method according to claim 15 , comprising the following steps:

wherein R 1 , R 3 and R 4 are as above defined.

20 . The method according to claim 19 , wherein the intermediate compound of formula (II) is selected from the group consisting of:

1,3-benzimidazol-2(3H)-ylidene(2-chloro-6-methylpyrimidin-4-yl)acetonitnle

1,3-benzimidazol-2(3H)-ylidene(2-chloro-6-methylpyrimidin-4-yl)acetonitrile

1,3-benzimidazol-2(3H)-ylidene(6-chloropyrimidin-4-yl)acetonitrile.