Thieno-pyridinone derivatives as kinase inhibitors

1. A compound of formula (I), or a pharmaceutically acceptable salt thereof:

wherein

R 1 represents an optionally substituted (C 3-7 cycloalkyl)methyl, or aryl group;

R 2 represents hydrogen, nitro, cyano, —CO 2 R a , —CONR b R c , —NR b R c , —NR d COR a , —NR d CO 2 R a , —NR d CONR b R c , —NR d SO 2 R a or —NR d CONHNHSO 2 R a ;

R 3 represents an optionally substituted aryl group;

wherein the optional substituents on R l and R 3 are selected from the group consisting of halogen, cyano, nitro, C 1-6 alkyl, trifluoromethyl, hydroxy, C 1-6 alkoxy, difluoromethoxy, trifluoromethoxy, C 1-6 alkylsulphonyl, amino, C 1-6 alkylamino, di(C 1-6 ) -alkylamino, aminocarbonyl, and C 2-6 alkoxycarbony;

R a represents hydrogens C 1-6 alkyl optionally substituted by amino, C 1-6 alkylamino or di(C 1-6 )alkylamino; or C 3-7 heterocycloalkyl optionally substituted by C 1-6 alkyl;

R b represents hydrogens C 1-6 alkyl optionally substituted by hydroxy, amino, C 1-6 alkylamino, di(C 1-6 )alkylamino or C 3-7 heterocycloalkyl; C 2-6 alkenyl; C 3-7 cycloalkyl optionally substituted by amino, C 1-6 alkylamino or di(C 1-6 )alkylamino; or C 3-7 heterocycloalkyl optionally substituted by C 1-6 alkyl; and

R c represents hydrogen or C 1-6 alkyl; or

R b and R c , when taken together with the nitrogen atom to which they are attached, represent azetidin-1-yl optionally substituted by hydroxy, amino, C 1-6 alkylamino or di(C 1-6 ) alkylamino; pyrrolidin-1-yl optionally substituted by hydroxy, hydroxymethyl, amino, C 1-6 alkylamino or di(C 1-6 )alkylamino; piperidin-1-yl optionally substituted by hydroxy, amino, C 1-6 alkylamino or di(C 1-6 )alkylamino; piperazin-1-yl optionally substituted by C 1-6 alkyl; or morpholin-4-yl; and

R d represents hydrogen or C 1-6 alkyl.

2. A compound as claimed in claim 1 wherein R 1 represents cyclopropylmethyl, phenyl, fluorophenyl, chlorophenyl, difluorophenyl, methylphenyl.

3. A compound as claimed in claim 1 wherein R 3 represents phenyl, fluorophenyl, difluorophenyl, chlorophenyl, (chloro)(fluoro)phenyl, bromophenyl, cyanophenyl, methylphenyl, (fluoro)(methyl)phenyl, dimethylphenyl, trifluoromethyl-phenyl, methoxyphenyl, (ethoxy)(methyl)phenyl, difluoromethoxy-phenyl, or trifluoromethoxy-phenyl.

4. A compound as claimed in claim 1 represented by formula (IIA) or a pharmaceutically acceptable salt thereof:

wherein

X represents CH;

Y represents CH; and

R 11 , R 12 , R 31 and R 32 each independently represent hydrogen, halogen, cyano, nitro, C 1-6 alkyl, trifluoromethyl, hydroxy, C 1-6 alkoxy, difluoromethoxy, trifluoromethoxy, C 1-6 alkylsulphonyl, amino, C 1-6 alkylamino, di(C 1-6 )alkylamino, aminocarbonyl or C 2-6 alkoxycarbonyl.

5. A compound as claimed in claim 1 wherein R 2 represents —NR b R c .

6. A compound as claimed in claim 1 represented by formula (IIB) or a pharmaceutically acceptable salt thereof:

wherein

W represents the residue of an azetidine, pyrrolidine or piperidine ring; and

R 21 represents hydrogen or C 1-6 alkyl.

7. A compound as claimed in claim 6 wherein R 21 represents methyl.

8. A compound as claimed in claim 1 that is:

Ethyl 3-(3-methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylate;

3-(3-Methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylic acid;

tert-Butyl[3-(3-methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]carbamate,

2-Amino-3-(3-methylbenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-(3-Methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridine-2-carbonitrile;

3-(3-Methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridine-2-carboxamide;

2-(Azetidin-1-ylcarbonyl)-3-(3-methylbenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-(3-Methylbenzoyl)-7-phenyl-2-(piperidin-1-yl)thieno[2,3-b]pyridin-6(7H)-one;

3-(3-Methylbenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

Ethyl 3-benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylate;

3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylic acid;

tert-Butyl(3-benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)carbamate;

2-Amino-3-benzoyl-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

N-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)acetamide;

N-[3-(3-Methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]acetamide;

N-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)methanesulfonamide;

N-[3-(3-Methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]methanesulfonamide;

2-(Azetidin-1-yl)-3-(3-methylbenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

N-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)piperidine-4-carboxamide;

N′-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)-N,N-dimethylurea;

N-(2-Hydroxy-2-methylpropyl)-N′-[3-(3-methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]urea;

4-Methyl-N-[3-(3-methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]piperazine-1-carboxamide;

N-[3-(3-Methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]urea;

N,N-Dimethyl-N′-[3-(3-methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]urea;

N-[3-(3-Methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]azetidine -1-carboxamide;

N-Allyl-N′-[3-(3-methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]urea;

(2R)-2-(Hydroxymethyl)-N-[3-(3-methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]pyrrolidine-1-carboxamide;

N-(1-Ethylpyrrolidin-3-yl)-N′-[3-(3-methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]urea;

N-[3-(3-Methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]-2-(methylsulfonyl)hydrazinecarboxamide;

3-Benzoyl-N-methyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridine-2-carboxamide;

2-(Azetidin-1-ylcarbonyl)-3-benzoyl-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-N-(1,1-dimethyl-2-hydroxyethyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridine-2-carboxamide;

3-Benzoyl-N,N-dimethyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridine-2-carboxamide;

3-Benzoyl-2-{[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]carbonyl}-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-2-(morpholin-4-ylcarbonyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-7-phenyl-2-(pyrrolidin-1-ylcarbonyl)thieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridine-2-carbonitrile;

3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridine-2-carboxamide;

Ethyl 3-benzoyl-7-(cyclopropylmethyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylate;

2-Amino-3-benzoyl-7-(cyclopropylmethyl)thieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-7-(2-chlorophenyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-2-carbonitrile;

2-Amino-3-benzoyl-7-(2-chlorophenyl)thieno[2,3-b]pyridin-6(7H)-one;

3-(3-Chlorobenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridine-2-carboxamide;

Ethyl 3-(3-chlorobenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylate;

2-Amino-3-(3-chlorobenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

N-[3-(3-Chlorobenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]acetamide;

3-(2,4-Difluorobenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridine-2-carboxamide;

3-(4-Fluoro-3-methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridine-2-carboxamide;

Ethyl 3-(4-fluoro-3-methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylate;

2-Amino-3-(4-fluoro-3-methylbenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

2-Amino-3-(4-ethoxy-3-methylbenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-(3-Chloro-4-fluorobenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridine-2-carboxamide,

3-Benzoyl-2-(dimethylamino)-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

2-Amino-7-phenyl-3-[3-(trifluoromethyl)benzoyl]thieno[2,3-b]pyridin-6(7H)-one;

N-{6-Oxo-7-phenyl-3-[3-(trifluoromethyl)benzoyl]-6,7-dihydrothieno[2,3-b]pyridin-2-yl}acetamide,

N-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)-1-methylpiperidine-4-carboxamide,

N-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)-1-ethylpiperidine-4-carboxamide;

N-{6-Oxo-7-phenyl-3-[3-(trifluoromethyl)benzoyl]-6,7-dihydrothieno[2,3-b]pyridin-2-yl}piperidine-4-carboxamide;

N-[3-(3-Chlorobenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]piperidine-4-carboxamide;

3-Benzoyl-2-[(3R)-3-hydroxypyrrolidin-1-yl]-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-7-phenyl-2-{[2-(piperidin-1-yl)ethyl]amino}thieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-7-phenyl-2-{[2-(pyrrolidin-1-yl)ethyl]amino}thieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-7-phenyl-2-(piperidin-3-ylamino)thieno[2,3-b]pyridin-6(7H)-one;

2-(Azetidin-3-ylamino)-3-benzoyl-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-2-[(1-methylazetidin-3-yl)amino]-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

2-Amino-3-(3-methoxybenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

2-Amino-3-(2-chlorobenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one,

2-Amino-3-(3-chloro-4-fluorobenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-[(2-Amino-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-3-yl)carbonyl]benzonitrile;

2-Amino-3-(2-fluorobenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one,

2-Amino-3-(4-chlorobenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

2-Amino-3-(4-fluorobenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one,

2-Amino-3-(3-bromobenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one,

2-Amino-3-(2,4-difluorobenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one,

2-Amino-7-phenyl-3-[3-(trifluoromethoxy)benzoyl]thieno[2,3-b]pyridin-6(7H)-one,

2-Amino-3-(3,4-dimethylbenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

2-Amino-3-(2-methoxybenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

2-[(2-Amino-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-3-yl)carbonyl]benzonitrile;

2-Amino-3-Benzoyl-7-(4-methylphenyl)thieno[2,3-b]pyridin-6(7H)-one;

N-[3-Benzoyl-7-(2-chlorophenyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-2-yl]acetamide;

N-[3-(3-Chloro-4-fluorobenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]acetamide;

N-[3-Benzoyl-7-(cyclopropylmethyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-2-yl]acetamide;

N-[3-(2-Fluorobenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]acetamide;

N-[3-(4-Fluoro-3-methylBenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]acetamide;

N-[3-(4-Fluorobenzoy1)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]acetamide;

N-[3-(3-MethoxyBenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]acetamide;

N-[3-(3-BromoBenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]acetamide;

2-Amino-7-phenyl-3-[4-(trifluoromethyl)benzoyl]thieno[2,3-b]pyridin-6(7H)-one;

4-[(2-Amino-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-3-yl)carbonyl]benzonitrile;

2-Amino-3-(4-methoxybenzoy1)-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

2-Amino-7-phenyl-3-[4-(trifluoromethoxy)benzoyl]thieno[2,3-b]pyridin-6(7H)-one,

2-Amino-3-(2-methylbenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one,

2-Amino-3-(4-methylbenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one:

2-Amino-7-phenyl-3-[2-(trifluoromethyl)benzoyl]thieno[2,3-b]pyridin-6(7H)-one;

2-Amino-3-[3-(difluoromethoxy)benzoyl]-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

2-Amino-3-[4-(difluorometholy)benzoyl]phenylthieno[2,3-b]pyridin-6(7H)-one;

2-Amino-3-[2-(difluoromethoxy)benzoyl]-7-phenylthieno[2,3-b]pyridin-6(7H)-one,

N-{6-Oxo-7-phenyl-3-[3-(trifluoromethoxy)benzoyl]-6,7-dihydrothieno[2,3-b]pyridin-2-yl}acetamide;

N-[3-(3,4-Dimethylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]acetamide,

N-[3-(2-Methoxybenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]acetamide;

N-[3-(2-Cyanobenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]acetamide;

N-[3-(2-Chlorobenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]acetamide;

N-[3-(2-Methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]acetamide;

N-[3-(4-Methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]acetamide;

N-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)-N′- 9 2-hydroxy-2-hydroxy-1,1-dimethylethyl)urea;

N-(3-Benzol-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)-N-(2-hydroxy-2-methylpropyl)urea;

N-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)-N′-(2-hydroxy-1,1-dimethylethyl)urea;

N-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)-4-methylpiperazine-1-carboxamide;

(3R)-N-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)-3-hydroxypyrrolidine-1-carboxamide;

2-Amino-7-(cyclopropylmethyl)-3-(4-fluoro-3-methylbenzoyl)thieno[2,3-b]pyridin-6(7H)-one;

N-[7-(Cyclopropylmethyl)-3-(4-fluoro-3-methylbenzoyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-2-yl]acetamide,

N-[7-(Cyclopropylmethyl)-3-(4-fluoro-3-methylbenzoyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-2-yl]-N′-(2-hydroxy-2-methylpropyl)urea;

N-[7-(Cyclopropylmethyl)-3-(4-fluoro-3-methylbenzoyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-2-yl]-N′-(2-hydroxy-1,1-dimethylethyl)urea;

7-(2-Chlorophenyl)-3-(4-fluoro-3-methylbenzoyl)-2-nitrothieno[2,3-b]pyridin-6(7H) -one;

2-Amino-7-(2-chlorophenyl)-3-(4-fluoro-3-methylbenzoyl)thieno[2,3-b]pyridin-6(7H) -one;

N-[7-(2-Chlorophenyl)-3-(4-fluoro-3-methylbenzoyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-2-yl]acetamide,

N-[3-Benzoyl-7-(2-chlorophenyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-2-yl]piperidine-4-carboxamide hydrochloride;

N-[3-Benzoyl-7-(2-chlorophenyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-2-yl]-N′-(2-hydroxy-1,1-dimethylethyl)urea;

N-[3-Benzoyl-7-(2-chlorophenyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-2-yl]-N′-(2-hydroxy-2-methylpropyl)urea;

N-[3-(4-Fluoro-3-methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]-N′-(2-hydroxy-2-methylpropyl)urea,

3-Benzoyl-2-nitro-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

2-Amino-7-phenyl-3-[2-(trifluoromethoxy)benzoyl]thieno[2,3-b]pyridin-6(7H)-one;

2-Amino-3-(3-fluorobenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

2-Amino-7-(2-chlorophenyl)-3-(3-methylbenzoyl)thieno[2,3-b]pyridin-6(7H)-one,

2-Amino-3-benzoyl-7-(2-fluorophenyl)thieno[2,3-b]pyridin-6(7H)-one; 2-Amino-3-(4-fluoro-3-methylbenzoyl)-7-(2-fluorophenyl)thieno[2,3-b]pyridin-6(7H)-one;

2-Amino-7-(2-fluorophenyl)-3-(3-methylbenzoyl)thieno[2,3-b]pyridin-6(7H)-one;

N-{3-[3-(Difluoromethoxy)benzoyl]-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl}acetamide;

N-[3-(3-Fluorobenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]acetamide;

N-[7-(2-Chlorophenyl)-3-(3-methylbenzoyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-2-yl]acetamide;

N-[3-Benzoyl-7-(2-fluorophenyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-2-yl]acetamide;

N-[3-(4-Fluoro-3-methylbenzoyl)-7-(2-fluorophenyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-2-yl]acetamide;

N-[7-(2-Fluorophenyl)-3-(3-methylbenzoyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-2-yl]acetamide;

N-1-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)glycinamide;

N-1-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)-N-2-methylglycinamide,

N-1-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)-N-2,N-2-dimethylglycinamide;

N-1-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)-D-alaninamide hydrochloride;

N-1-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)-beta-alaninamide hydrochloride;

N-[3-Benzoyl-7-(cyclopropylmethyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-2-yl]piperidine-4-carboxamide hydrochloride,

N-[3-(4-Fluoro-3-methylbenzoyl)-7-(2-fluorophenyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-2-yl]piperidine-4-carboxamide hydrochloride;

N-[3-(4-Fluoro-3-methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]piperidine-4-carboxamide;

N-[3-Benzoyl-7-(2-chlorophenyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-2-yl]-1-methylpiperidine-4-carboxamide;

N-[3-(4-Fluoro-3-methylbenzoyl)-7-(2-fluorophenyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-2-yl]-1-methylpiperidine-4-carboxamide;

N-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)-D-prolinamide hydrochloride;

N-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)-L-prolinamide hydrochloride;

N-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)-1-methyl-L-prolinamide;

N-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)-1-methyl-D-prolinamide,

N-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)-N′-(2-hydroxyethyl)urea;

N-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)-N′-[(3R)-1-methylpyrrolidin-3-yl]urea;

(3R)-N-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide:

(3S)-N-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide;

N-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)-N′-[(3S)-pyrrolidin-3-yl]urea hydrochloride;

(3R)-3-Amino-N-(3-benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)pyrrolidine-1-carboxamide hydrochloride;

(3S)-3-Amino-N-(3-benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)pyrrolidine-1-carboxamide hydrochloride;

N-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)-N′-[(3S)-1-methylpyrrolidin-3-yl]urea;

(3S)-N-(3-Benzoyl-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)-3-(isopropylamino)pyrrolidine-1-carboxamide;

N-[3-(4-Fluoro-3-methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]-N′-(1,1-dimethyl-2-hydroxyethyl)urea;

N-[3-(4-Fluoro-3-methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]-N′-[(3R)-pyrrolidin-3-yl]urea hydrochloride;

N-[3-(4-Fluoro-3-methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]-N′-[(3R)-1-methylpyrrolidin-3-yl]urea;

N-[(3R)-1-Ethylpyrrolidin-3-yl]-N′-[3-(4-fluoro-3-methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]urea;

(3R)-3-(Dimethylamino)-N-[3-(4-fluoro-3-methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]pyrrolidine-1-carboxamide;

(3S)-3-(Dimethylamino)-N-[3-(4-fluoro-3-methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]pyrrolidine-1-carboxamide;

N-[3-(4-Fluoro-3-methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]-4-methylpiperazine-1-carboxamide;

N-[7-(2-Chlorophenyl)-3-(4-fluoro-3-methylbenzoyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-2-yl]-N′-(1,1-dimethyl-2-hydroxyethyl)urea;

N-[3-Benzoyl-7-(cyclopropylmethyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-2-yl]-N′-(1,1-dimethyl-2-hydroxyethyl)urea;

N-[3-Benzoyl-7-(cyclopropylmethyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-2-yl]-N′-(2-hydroxy-2-methylpropyl)urea,

3-Benzoyl-7-phenyl-2-(piperidin-4-ylamino)thieno[2,3-b]pyridin-6(7H)-one,

3-Benzoyl-2-[(1-methylpiperidin-4-yl)amino]-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-7-phenyl-2-[(3R)-pyrrolidin-3-ylamino]thieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-2-{[(3R)-1-methylpyrrolidin-3-yl]amino}-7-phenylthieno[2,3-b]pyridin-6(7H)-one hydrochloride;

3-Benzoyl-7-phenyl-2-[(3S)-pyrrolidin-3-ylamino]thieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-2-{[(3S)-1-methylpyrrolidin-3-yl]amino}-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

2-(3-Aminoazetidin-1-yl)-3-benzoyl-7-phenylthieno[2,3-b]pyridin-6(7H)-one,

2-(4-Aminopiperidin-1-yl)-3-benzoyl-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-2-[3-(dimethylamino)azetidin-1-yl]-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

2-[(Azetidin-3-ylmethyl)amino]-3-benzoyl-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-2-{[(1-methylazetidin-3-yl)methyl]amino}-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-2-(morpholin-4-yl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one,

3-Benzoyl-2-{[3-(dimethylamino)-2,2-dimethylpropyl]amino}-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

N-[3-(4-Fluoro-3-methylbenzoyl)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl]-1-methylpiperidine-4-carboxamide,

2-(Azetidin-3-ylamino)-3-(4-fluoro-3-methylbenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-(4-Fluoro-3-methylbenzoyl)-2-[(1-methylazetidin-3-yl)amino]-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-(4-Fluoro-3-methylbenzoyl)-7-phenyl-2-(piperidin-4-ylamino)thieno[2,3-b]pyridin-6(7H)-one;

3-(4-Fluoro-3-methylbenzoyl)-2-[(1-methylpiperidin-4-yl)amino]-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-(4-Fluoro-3-methylbenzoyl)-7-phenyl-2-[(3R)-pyrrolidin-3-ylamino]thieno[2,3-b]pyridin-6(7H)-one;

3-(4-Fluoro-3-methylbenzoyl)-2-{[(3R)-1-methylpyrrolidin-3-yl]amino}-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-(4-Fluoro-3-methylbenzoyl)-7-phenyl-2-[(3S)-pyrrolidin-3-ylamino]thieno[2,3-b]pyridin-6(7H)-one;

3-(4-Fluoro-3-methylbenzoyl)-2-{[(3S)-1-methylpyrrolidin-3-yl]amino}-7-phenylthieno[2,3-b]pyridin-6(7H)-one,

3-(3-Methylbenzoyl)-7-phenyl-2-(piperidin-4-ylamino)thieno[2,3-b]pyridin-6(7H)-one,

3-(3-Methylbenzoyl)-2-[(1-methylpiperidin-4-yl)amino]-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

2-(Azetidin-3-ylamino)-3-(3-methylbenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

2-[(1-Methylazetidin-3-yl)amino]-3-(3-methylbenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-7-phenyl-2-[(3R)-piperidin-3-ylamino]thieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-2-{[(3R)-1-methylpiperidin-3-yl]amino}-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-7-phenyl-2-[(3S)-piperidin-3-ylamino]thieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-2-{[(3S)-1-methylpiperidin-3-yl]amino}-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-2-[(1-ethylazetidin-3-yl)amino]-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-2-[(1-isopriopylazeidin-3-yl)amino]-7-phenylthieno[ 2 , 3 -b]pyridin-6(7)-one;

3-Benzoyl-2[(1-ethylpiperidin-4-yl)amino]-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-2-[(1-isopropylazetidin-4-yl)amino]-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-2-{[(3S)-1-isopropylpyrrolidin-3-yl)amino]-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

2-[(trans-4-Aminocyclohexyl)amino]-3-benzoyl-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

2-[(1-Ethylpiperidin-4-yl)amino]-3-(3-methylbenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

2-[(1-Isopropylpiperidin-4-yl)amino]-3-(3-methylbenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-(3-Methylbenzoyl)-7-phenyl-2-[(3S)-pyrrolidin-3-ylamino]thieno[2,3-b]pyridin-6(7H)-one,

3-(3-Methylbenzoyl)-2-{[(3S)-1-methylpyrrolidin-3-yl]amino}-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

2-[(1-Ethylazetidin-3-yl)amino]-3-(4-fluoro-3-methylbenzoyl)-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-(4-Fluoro-3-methylbenzoyl)-2-[(1-isopropylazetidin-3-yl)amino]-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-7-(cyclopropylmethyl)-2-[(1-methylazetidin-3-yl)amino]thieno[2,3-b]pyridin-6(7H)-one,

2-(Azetidin-3-ylamino)-7-(cyclopropylmethyl)-3-(4-fluoro-3-methylbenzoyl)thieno[2,3-b]pyridin-6(7H)-one;

7-(Cyclopropylmethyl)-3-(4-fluoro-3-methylbenzoyl)-2-[(1-methylazetidin-3-yl)amino]thieno[2,3-b]pyridin-6(7H)-one;

3-(3-Methoxybenzoyl)-2-[(1-methylpiperidin-4-yl)amino]-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

3-(3-Chloro-4-fluorobenzoyl)-2-[(1-methylpiperidin-4-yl)amino]-7-phenylthieno[2,3-b]pyridin-6(7H)-one;

2-Amino-3-benzoyl-7-(2,6-difluorophenyl)thieno[2,3-b]pyridin-6(7H)-one;

2-(Azetidin-3-ylamino)-3-benzoyl-7-(2,6-difluorophenyl)thieno[2,3-b]pyridin-6(7H)-one,

3-Benzoyl-7-(2,6-difluorophenyl)-2-[(1-methylazetidin-3-yl)amino]thieno[2,3-b]pyridin-6(7H)-one;

2-Amino-7-(2,6-difluorophenyl)-3-(4-fluoro-3-methylbenzoyl)thieno[2,3-b]pyridin-6(7H)-one;

N-[7-(2,6-Difluorophenyl)-3-(4-fluoro-3-methylbenzoyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-2-yl]-1-methylpiperidine-4-carboxamide;

7-(2,6-Difluorophenyl)-3-(4-fluoro-3-methylbenzoyl)-2-[(1-methylpiperidin-4-yl)amino]thieno[2,3-b]pyridin-6(7H)-one;

2-(Azetidin-3-ylamino)-3-benzoyl-7-(4-methylphenyl)thieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-2-[(1-methylazetidin-3-yl)amino]-7-(4-methylphenyl)thieno[2,3-b]pyridin-6(7H)-one;

2-Amino-3-(4-fluoro-3-methylbenzoyl)-7-(4-methylphenyl)thieno[2,3-b]pyridin-6(7H)-one;

2-(Azetidin-3-ylamino)-3-(4-fluoro-3-methylbenzoyl)-7-(4-methylphenyl)thieno[2,3-b]pyridin-6(7H)-one;

3-(4-Fluoro-3-methylbenzoyl)-2-[(1-methylazetidin-3-yl)amino]-7-(4-methylphenyl)thieno[2,3-b]pyridin-6(7H)-one;

2-Amino-3-(4-fluoro-3-methylbenzoyl)-7-(4-fluorophenyl)thieno[2,3-b]pyridin-6(7H)-one;

2-Amino-3-benzoyl-7-(4-fluorophenyl)thieno[2,3-b]pyridin-6(7H)-one;

3-Benzoyl-7-(4-fluorophenyl)-2-[(1-methylpiperidin-4-yl)amino]thieno[2,3-b]pyridin-6(7H)-one,

2-(Azetidin-3-ylamino)-7-(2,6-difluorophenyl)-3-(4-fluoro-3-methylbenzoyl)thieno[2,3-b]pyridin-6(7H)-one; or

3-(4-Fluoro-3-methylbenzoyl)-7-(4-fluorophenyl)-2-[(1-methylpiperidin-4-yl)amino]thieno[2,3-b]pyridin-6(7H)-one.

9. A pharmaceutical composition comprising a compound as claimed in claim 1 , or a pharmaceutically acceptable salt thereof, in association with a pharmaceutically acceptable carrier.