IP Library Granted Patent US 7,678,780
Granted Patent B2
US 7,678,780 · App. 10/581,577 · Granted Mar 16, 2010

Method of treating cancer using platelet releasate

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Quick Facts
Patent No.
US 7,678,780
App. No.
10/581,577
Granted
Mar 16, 2010
Kind
B2
Abstract

Platelets are concentrated from the blood of a patient. The platelets are treated by a method such as ultrasound or agitation to obtain platelet releasate. This releasate as a whole or a component thereof is formulated into an injectable formulation which is administered to the same patient the platelets were extracted from in order to treat the patient's cancer.

Claims (13)

1. A method for treating glioblastoma cancer comprising:

extracting blood from a patient in need of cancer treatment;

concentrating platelets from the blood;

processing the platelets in a manner which breaks open the platelets and obtaining an injectable platelet releasate;

formulating the platelet releasate into an injectable formulation buffered to a pH of 7.4±5%; and

injecting the platelet releasate to the patient in need of said glioblastoma cancer treatment.

2. The method of claim 1 , wherein the processing comprises exposing the platelets to energy waves.

3. The method of claim 1 , wherein the administering comprises injecting the platelet releasate into a tumor of the patient.

4. The method of claim 1 , wherein the administering comprises injecting the platelet releasate into a cancerous tumor of the patient.

5. The method of claim 1 , wherein the patient treated with the formulation is the same patient from which the blood is extracted from, and the formulation is buffered to pH 7.4±2%; and wherein the platelets are processed for a period of time and under conditions so as to break open 90% or more of the platelets.

6. The method of claim 5 , further comprising:

repeatedly injecting a therapeutically effective amount of the formulation to the patient over a period of time while monitoring the patient and adjusting dosing to effectively treat the cancer.

7. The method of claim 1 , wherein injecting of the injectable platelet releasate is to an area where a tumor has been removed from the patient.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 6, 2021
From: MISHRA, ALLAN, DR.
To: BLUE ENGINE BIOLOGICS, LLC
Reel/Frame 056759/0943 →
TO CORRECT RECORDATION INFORMATION AT REEL 018186 FRAME 0674,DATED AUG. 29 2006. THE CORRECT ASSIGNOR IS AM BIOSOLUTIONS,INC.,A CORP. THE CORRECT ASSIGNEE IS ALLAN MISHRA,AN INDIVIDUAL Recorded Mar 11, 2008
From: AM BIOSOLUTIONS, INC.
To: MISHRA,ALLAN
Reel/Frame 020636/0354 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 29, 2006
From: MISHRA, ALLAN
To: AM BIOSOLUTIONS, INC.
Reel/Frame 018186/0674 →