IP Library › Granted Patent US 7,897,566
Granted Patent B2
US 7,897,566 · App. 10/582,534 · Granted Mar 1, 2011

Analogues of GLP-1

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Quick Facts
Patent No.
US 7,897,566
App. No.
10/582,534
Granted
Mar 1, 2011
Kind
B2
Abstract

Disclosed are peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, methods of using such analogues to treat mammals and pharmaceutical compositions useful therefor comprising said analogues.

Claims (28)

1. A compound according to the formula:

(Aib 8,35 , Arg 26,34 , Phe 31 , Pro 37 , Ser 38,39 )hGLP-1(7-39)-NH 2 ; (SEQ ID NO:1)

(Aib 8,35,37 , Arg 26,34 , Phe 31 , Asn 38 )hGLP-1(7-38)-NH 2 ; (SEQ ID NO:2)

(Aib 8,35,37 , Arg 26,34 , Phe 31 , Ser 38 )hGLP-1(7-38) NH 2 ; (SEQ ID NO:3)

(Aib 8,35,37 , Gaba 38 )hGLP-1(7-38) NH 2 ; (SEQ ID NO:4)

(Aib 8,35,37 , Arg 26,34 , Phe 31 , His 38 )hGLP-1(7-38) NH 2 ; (SEQ ID NO:5)

(Aib 8,35 , Arg 26,34 , Phe 31 , β-Ala 37 , His 38 )hGLP-1(7-38) NH 2 ; (SEQ ID NO:6)

(Aib 8,35,37 , Arg 26,34 , D-His 38 )hGLP-1(7-38) NH 2 ; (SEQ ID NO:7)

(Aib 8,35,37 , β-Ala 38 )hGLP-1(7-38) NH 2 ; (SEQ ID NO:8)

(Aib 8,35 , Arg 26,34 , β-Ala 37 , His 38 )hGLP-1(7-38) NH 2 ; (SEQ ID NO:9)

(Aib 8,35,37 , Arg 26,34 , Phe 31 , Gly 38 )hGLP-1(7-38) NH 2 ; (SEQ ID NO:10)

(Aib 8,35,37 , Arg 26,34 , Gly 38 )hGLP-1(7-38) NH 2 ; (SEQ ID NO:11)

(Aib 8,35,37 , Arg 26,34 , β-Ala 38 )hGLP-1(7-38) NH 2 ; (SEQ ID NO:12)

(Aib 8,35,37 , Arg 26,34 , Gaba 38 )hGLP-1(7-38) NH 2 ; (SEQ ID NO:13)

(Aib 8,35,37 , Arg 34 , Phe 31 , His 38 )hGLP-1(7-38) NH 2 ; (SEQ ID NO:14)

(Aib 8,35,37 , Arg 26,34 , His 38 )hGLP-1(7-38) NH 2 ; (SEQ ID NO:15)

(Aib 8,35,37 , Arg 26,34 , Phe 31 , Gaba 38 )hGLP-1(7-38) NH 2 ; (SEQ ID NO:16)

(Aib 8,35,37 , Arg 34 , Phe 31 , D-His 38 )hGLP-1(7-38) NH 2 ; (SEQ ID NO:19)

(Aib 8,35,37 , Arg 34 , Phe 31 , Gly 38 )hGLP-1(7-38) NH 2 ; (SEQ ID NO:20)

(Aib 8,35,37 , Gly 38 )hGLP-1(7-38) NH 2 ; (SEQ ID NO:21)

(Aib 8,35,37 , Arg 26,34 , Phe 31 , D-His 38 )hGLP-1(7-38) NH 2 ; (SEQ ID NO:22)

(Aib 8,35 , Arg 26,34 , Phe 31 , β-Ala 37 , D-His 38 )hGLP-1(7-38) NH 2 ; (SEQ ID NO:23)

(Aib 8,35,37 , Arg 26,34 , Phe 31 , β-Ala 38 )hGLP-1(7-38) NH 2 ; (SEQ ID NO:24)

(Aib 8,35 , Arg 26,34 , Phe 31 , β-Ala 37,38 )hGLP-1(7-38) NH 2 ; (SEQ ID NO:25)

(Aib 8,35,37 , Arg 34 , Phe 31 , β-Ala 38 )hGLP-1(7-38) NH 2 ; (SEQ ID NO:26) or

(Aib 8,35,37 , Arg 34 , Phe 31 , Gaba 38 )hGLP-1(7-38) NH 2 ; (SEQ ID NO:27)

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising a compound according to claim 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier or diluent.

Assignments (5)
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNOR NAME PREVIOUSLY RECORDED ON REEL 296336 FRAME 0777. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Jan 5, 2016
From: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES, S.A.S.
To: IPSEN PHARMA S.A.S.
Reel/Frame 037430/0194 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ADDRESS PREVIOUSLY RECORDED ON REEL 023034 FRAME 0251. ASSIGNOR(S) HEREBY CONFIRMS THE ADDRESS SHOULD BE 65 QUAI GEORGES GORSE, 92100 BOULOGNE-BILLANCOURT, FRANCE. Recorded Jan 16, 2013
From: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATION SCIENTIFIQUES (S.C.R.A.S.)
To: IPSEN PHARMA S.A.S.
Reel/Frame 029636/0777 →
CHANGE OF NAME Recorded Jul 31, 2009
From: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATION SCIENTIFIQUES (S.C.R.A.S.)
To: IPSEN PHARMA S.A.S.
Reel/Frame 023034/0251 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 5, 2006
From: DONG, ZHENG XIN
To: BIOMEASURE, INCORPORATED
Reel/Frame 018259/0538 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 5, 2006
From: BIOMEASURE, INCORPORATED
To: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES, S.A.S.
Reel/Frame 018259/0958 →