IP Library › Granted Patent US 7,919,578
Granted Patent B2
US 7,919,578 · App. 10/582,662 · Granted Apr 5, 2011

Methods and compositions for inhibition of BCL6 repression

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Quick Facts
Patent No.
US 7,919,578
App. No.
10/582,662
Granted
Apr 5, 2011
Kind
B2
Abstract

Provided are peptides or mimetics that block corepressor binding to a BCL6 lateral groove. Also provided are methods of blocking corepressor binding to the BCL6 lateral groove. Additionally, methods of inhibiting BCL6 repression in a mammalian, cell, and methods of treating a mammal with cancer are provided.

Claims (4)

1. An isolated compound comprising the amino acid sequence of SEQ ID NO: 1, wherein the compound has 21 amino acids or less.

2. The isolated compound of claim 1 , consisting of the amino acid sequence of SEQ ID NO: 1.

3. The isolated compound of claim 1 , which further comprises a moiety that facilitates entry of the compound into a cell.

4. The isolated compound of claim 2 , which further comprises a moiety that facilitates entry of the compound into a cell.

Assignments (3)
MERGER AND CHANGE OF NAME Recorded Feb 26, 2019
From: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.; ALBERT EINSTEIN COLLEGE OF MEDICINE
To: ALBERT EINSTEIN COLLEGE OF MEDICINE
Reel/Frame 048438/0275 →
CHANGE OF NAME Recorded Oct 19, 2015
From: COM AFFILIATION, INC.
To: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
Reel/Frame 036888/0927 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 15, 2015
From: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
To: COM AFFILIATION, INC.
Reel/Frame 036875/0057 →