Thiazole derivatives
View Patent ↗(Wherein n is an integer of from 0 to 3; R 1 is substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, a substituted or unsubstituted alicyclic heterocyclic group, or a substituted or unsubstituted aromatic heterocyclic group; R 2 is halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, a substituted or unsubstituted alicyclic heterocyclic group, a substituted or unsubstituted aromatic heterocyclic group, —COR 8 , or the like; R 3 and R 4 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl, —COR 12 , or the like) For example, provided are adenosine A 2A receptor antagonists comprising, as the active ingredient, a thiazole derivative represented by a general formula (I), or a pharmaceutically acceptable salt thereof, and the like.
1. A thiazole derivative represented by a formula (IA):
wherein
R 1A represents 5-membered aromatic heterocyclic group containing at least one oxygen atom;
n represents an integer of from 0 to 3;
represents a substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, a substituted or unsubstituted alicyclic heterocyclic group, a substituted or unsubstituted aromatic heterocyclic group, substituted or unsubstituted alicyclic heterocyclic-alkyl, or substituted or unsubstituted aromatic heterocyclic-alkyl;
R 3A represents a hydrogen atom, or substituted or unsubstituted lower alkyl; and
R 2A represents —COR 8 (wherein R 8 represents a substituted or unsubstituted alicyclic heterocyclic group containing at least one oxygen atom),
or a pharmaceutically acceptable salt thereof.
2. The thiazole derivative according to claim 1 , wherein R 1A is substituted or unsubstituted furyl, or a pharmaceutically acceptable salt thereof.
3. The thiazole derivative according to claim 1 , wherein n is 0, or a pharmaceutically acceptable salt thereof.
4. The thiazole derivative according to claim 1 , wherein R 3A is a hydrogen atom, or a pharmaceutically acceptable salt thereof.
5. The thiazole derivative according to claim 1 , wherein R 3A is lower alkyl, or a pharmaceutically acceptable salt thereof.
6. The thiazole derivative according to claim 1 , wherein R 1A is furyl, or a pharmaceutically acceptable salt thereof.
7. The thiazole derivative according to claim 6 , wherein n is 0, or a pharmaceutically acceptable salt thereof.
8. The thiazole derivative according to claim 7 , wherein R 3A is a hydrogen atom, or a pharmaceutically acceptable salt thereof.
9. The thiazole derivative according to claim 8 , wherein R 12 is substituted or unsubstituted phenyl, or substituted or unsubstituted aromatic heterocyclic group, or a pharmaceutically acceptable salt thereof.
10. The thiazole derivative according to claim 8 , wherein R 12 is substituted or unsubstituted alicyclic heterocyclic-methyl, or a pharmaceutically acceptable salt thereof.
11. The thiazole derivative according to claim 8 , wherein R 12 is substituted or unsubstituted pyridyl, or a pharmaceutically acceptable salt thereof.
12. The thiazole derivative according to any one of claims 9 to 11 , wherein R 8 is tetrahydropyranyl, or a pharmaceutically acceptable salt thereof.
13. A thiazole derivative selected from the group consisting of the following formulae, or a pharmaceutically acceptable salt thereof: