Sterilization system and method
View Patent ↗A system, device and method for sterilizing or decontaminating an object that includes a sealable sterilizing chamber ( 12 ) and a sterilant gas-generating composition ( 24 ) that preferably generates NO or a mixture of NO and NO 2 . The preferred sterilant gas-generating composition ( 24 ) includes a carbon-based diazeniumdiolate compound and a powdered acid.
1. A system or device for sterilizing a material comprising:
a gas generating chamber;
a sealable sterilizing chamber in fluid communication with the gas generating chamber and configured to hold the material to be sterilized;
a valve, configured and arranged to controllably allow flow between the gas generating chamber and the sterilizing chamber; and
a sterilant gas-generating composition within the gas generating chamber, wherein said sterilant gas-generating composition is selected to generate a sterilant gas comprising a mixture of NO and NO 2 .
2. The system or device of claim 1 , wherein said sterilant gas-generating composition is freely exposed to an inner wall of the sterilization chamber.
3. The system or device of claim 1 , wherein said sterilant gas-generating composition comprises a carbon-based diazeniumdiolate compound.
4. The system or device of claim 3 , wherein the sterilant gas-generating composition requires from about 2 seconds to about 30 seconds to release sufficient quantities of NO and NO 2 to sterilize an object in the sterilization chamber.
5. The system or device of claim 3 , wherein said carbon-based diazeniumdiolate compound produces quantities of NO that are greater than 1 mole of NO per mole of said carbon-based diazeniumdiolate compound.
6. The system or device of claim 3 , wherein said carbon-based diazeniumdiolate has a carbon bearing a diazeniumdiolate group, wherein said carbon does not comprise part of an imidiate, thioimidate, amidine or enamine.
7. The system or device of claim 3 , wherein said carbon-based diazeniumdiolate compound is a C-based diazeniumdiolate compound having the formula:
R 3 —C(R 1 ) x (N 2 O 2 R 2 ) y
wherein x is an integer from 0 to 2 and y is an integer from 1 to 3 and the sum of x plus y equals 3;
wherein R 1 is not an imidiate, thioimidate, amidine or enamine;
wherein R 2 is selected from the group consisting of a countercation and a protecting group on the terminal oxygen; and
wherein R 3 is a phenyl group.
8. The system or device of claim 3 , wherein said carbon-based diazeniumdiolate compound has the formula:
wherein R 1 is not an imidiate, thioimidate, amidine or enamine;
wherein R 2 is selected from the group consisting of a countercation and a protecting group on the terminal oxygen; and
wherein R 3 is a phenyl.
9. The system or device of claim 8 , wherein R 1 is selected from the group consisting of an electron withdrawing group, a nitro group, an ether, a thioether, and a non-enamine amine;
wherein the R 3 substituent is selected from the group consisting of aliphatic, aromatic, and non-aromatic cyclic groups; and
wherein the R 3 substituent is selected from the group consisting of mono- or di-substituted amino, unsubstituted amino, ammonium, alkoxy, acetoxy, aryloxy, acetamide, aldehyde, benzyl, cyano, nitro, thio, sulfonic, vinyl, carboxyl, nitroso, trihalosilane, trialkylsilane, trialkylsiloxane, trialkoxysilane, diazeniumdiolate, hydroxyl, halogen, trihalomethyl, ketone, benzyl, and alkylthio.
10. The system or device of claim 8 , wherein the countercation is selected from the group consisting of, ammonium and other quaternary amines;
and further wherein the protecting group is selected from the group consisting of aryl, sulfonyl, glycosyl, acyl, alkyl and olefinic groups.
11. The system or device of claim 1 , wherein said sterilant gas-generating composition comprises a nitrogen-based diazeniumdiolate compound.
12. The system or device of claim 1 , wherein said sterilant gas-generating composition further comprises an activator, wherein said activator is an acid.
13. The system or device of claim 12 , wherein said acid is selected from the group consisting of oxalic acid and maleic acid.
14. The system or device of claim 1 , wherein the sterilizing chamber is impermeable to liquid and/or gas.
15. The system or device of claim 1 , further comprises a scrubbing system.
16. The system or device of claim 15 , wherein said scrubbing system comprises an oxidizer to convert NO to NO 2 .
17. The system or device of claim 15 , wherein said scrubbing system comprises an adsorbent to trap NO 2 .