IP Library › Granted Patent US 7,932,382
Granted Patent B2
US 7,932,382 · App. 10/586,271 · Granted Apr 26, 2011

Conformationally constrained Smac mimetics and the uses thereof

Assignee: The Regents of the University of Michigan
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Quick Facts
Patent No.
US 7,932,382
App. No.
10/586,271
Granted
Apr 26, 2011
Kind
B2
Abstract

The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.

Claims (10)

1. A compound having Formula I:

or a pharmaceutically acceptable salt thereof, wherein:

R 1 is C 1-2 alkyl or C 1-2 haloalkyl;

R 2 is branched or unbranched alkyl or cycloalkyl or substituted or unsubstituted aryl, alkylaryl, heteroaryl, or alkylheteroaryl;

X is CONH;

Y 1 is (CH 2 ) 1-5 ; Y 2 is(CH 2 ) 1-5 ;

Z is CONH.

2. The compound of claim 1 , wherein said compound is selected from the group consisting of:

3. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.

4. The pharmaceutical composition of claim 3 , wherein said compound is selected from the group consisting of:

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 27, 2008
From: XU, LIANG; WANG, SHAOMENG; SUN, HAIYING; NIKOLOVSKA-COLESKA, ZANETA; YANG, CHAO-YIE
To: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Reel/Frame 021001/0103 →
Continuity (1)
Related Publication 20080269140A1 · Oct 30, 2008