Amylin family peptides
View Patent ↗The present invention relates to obesity related polypeptides (ORPs), related nucleic acids, expression constructs, host cells, and processes production of the obesity related polypeptides. The ORPs of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent metabolic disorders such as obesity, diabetes, and increased cardiovascular risk.
1. A peptide having at least 92% sequence identity to the amino acid sequence of SEQ ID NO: 137.
2. The peptide of claim 1 , wherein the peptide having at least 92% sequence identity comprises the amino acid sequence of SEQ ID NO: 55, 67, 70, 73, 82, 83, 84, 89, 94, 100, 103, 106, 107, 111, 112, 125, 133, or 137.
3. The peptide of claim 1 , wherein the peptide is linked to a polyethylene glycol polymer, a polyamino acid, or a fatty acid.
4. A peptide having at least 95% sequence identity to the amino acid sequence of SEQ ID NO: 137.
5. The peptide of claim 4 , wherein the peptide having at least 95% sequence identity comprises the amino acid sequence of SEQ ID NO: 40, 42, 43, 46, 47, 48, 54, 64, 65, 68, 69, 74, 78, 79, 80, 81, 85, 90, 91, 92, 93, 95, 96, 97, 98, 99, 101, 102, 109, 118, 119, 121, 130, or 137.
6. A peptide having at least 95% sequence identity to the amino acid sequence of SEQ ID NO: 43.
7. The peptide of claim 6 , wherein the peptide having at least 95% sequence identity comprises the amino acid sequence of SEQ ID NO: 43 or 137.
8. The peptide of claim 7 , wherein the peptide is linked to a polyethylene glycol polymer, a polyamino acid, or a fatty acid.
9. A peptide comprising the amino acid sequence of SEQ ID NO:137.
10. The peptide of claim 9 , wherein the peptide is linked to a polyethylene glycol polymer, a polyamino acid, or a fatty acid.