IP Library › Granted Patent US 8,431,604

Granted Patent B2

US 8,431,604 · App. 10/590,265 · Granted Apr 30, 2013

Guanidine compounds, and use thereof as binding partners for 5-HT5 receptors

View Patent ↗

Loading inventors, assignments & file history…

Monitor This Case

Get email alerts when status or documents change.

Order Certified Copies

Most orders are placed with the USPTO same day — all within 24 business hours.

Order via The Patent Place →

Pre-filled with this patent's details

Quick Facts

Patent No.: US 8,431,604
App. No.: 10/590,265
Granted: Apr 30, 2013
Kind: B2

External Links

USPTO Patent Center↗ Full Patent PDF↗

Abstract

The present invention relates to guanidine compounds of the general formula I corresponding enantiomeric, diastereomeric and/or tautomeric forms thereof as well as pharmaceutically acceptable salts thereof. The present compound further relates to the use of guanidine compounds as binding partners for 5-HT5 receptors for the treatment of diseases which are modulated by a 5-HT5 receptor activity, in particular for the treatment of neurodegenerative and neuropsychiatric disorders as well as the associated signs, symptoms and dysfunctions.

Claims (220)

1. A guanidine compound of the formula I

corresponding enantiomeric, diastereomeric and/or tautomeric forms thereof, as well as pharmaceutically acceptable salts thereof, wherein the given moieties have the following definitions:

a moiety of the formula W1

wherein

NO 2 , NH 2 , OH, CN, CF 3 , OCF 3 , CHF 2 , OCHF 2 , COOH, O—CH 2 —COOH, halogen, SH, or

each optionally substituted C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 7 -cycloalkyl, C 1 -C 4 -alkylene-C 3 -C 7 -cycloalkyl, C 1 -C 4 -alkylene-heterocyclo-alkyl, aryl, hetaryl, heterocycloalkyl, C 1 -C 4 -alkylene-hetaryl or C 1 -C 4 -alkylene-aryl, or

O—R A 1 , CO—R A 1 , S—R A 1 , SO—R A 1 , CO—O—R A 1 , NR A 4 —CO—O—R A 1 , O—CH 2 —COO—R A 1 , NR A 2 R A 3 , CONH 2 , SO 2 NH 2 , NR A 4 —CO—R A 1 , SO 2 —R A 1 , NR A 4 —SO 2 —R A 1 , SO 2 —NR A 2 R A 3 or CO—NR A 2 R A 3 ;

R A 1 :

R A 2 :

hydrogen, OH, CN, or

each optionally substituted C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 1 -C 4 -alkylene-C 3 -C 7 -cycloalkyl, C 1 -C 4 -alkylene-heterocycloalkyl, aryl, hetaryl, heterocycloalkyl, C 1 -C 4 -alkylene-aryl, C 1 -C 4 -alkylene-hetaryl, C 1 -C 6 -alkylene-O—C 1 -C 6 -alkyl, CO—C 1 -C 6 -alkyl, CO-aryl, CO-hetaryl, CO—C 1 -C 4 -alkylene-aryl, CO—C 1 -C 4 -alkylene-hetaryl, CO—O—C 1 -C 6 -alkyl, CO—O-aryl, CO—O—C 1 -C 4 -alkylene-aryl, CO—O-hetaryl, CO—O—C 1 -C 4 -alkylene-hetaryl, SO 2 —C 1 -C 6 -alkyl, SO 2 -aryl, SO 2 -hetaryl, SO 2 —C 1 -C 4 -alkylene-aryl or SO 2 —C 1 -C 4 -alkylene-hetaryl;

R A 3 :

or the moieties R A 2 and R A 3 form, together with the nitrogen, a 3 to 7-membered, optionally substituted, saturated or aromatic heterocycle which can contain one, two or three different or same heteroatoms from the group O, N, S; wherein optionally two moieties substituted on this heterocycle can together form an anellated, saturated, unsaturated or aromatic carbocycle or heterocycle, wherein the heterocycle can contain up to three different or same heteroatoms O, N, S, and wherein the cycle formed can optionally be substituted or a further, optionally substituted cycle can be condensed onto this cycle;

R A 4 :

hydrogen or

each optionally substituted C 1 -C 6 -alkyl, C 1 -C 6 -alkylene-O—C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 3 -C 12 -alkynyl, CO—C 1 -C 6 -alkyl, CO—O—C 1 -C 6 -alkyl, SO 2 —C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, aryl, C 1 -C 4 -alkylene-aryl, CO—O-arylalkyl, CO—C 1 -C 4 -alkylene-aryl, CO-aryl, SO 2 -aryl, hetaryl, CO-hetaryl or SO 2 —C 1 -C 4 -alkylene-aryl;

hydrogen or as moiety A is defined,

or each independently of one another, two of the moieties A, B or R W 1 form, together with a 3 to 7-membered, optionally substituted, saturated or unsaturated carbocycle or an optionally substituted, saturated or unsaturated or aromatic heterocycle which can contain one, two or three further different or same heteroatoms from the group O, N, S; wherein optionally two of the moieties substituted on this carbo- or heterocycle can together form an anellated, saturated, unsaturated or aromatic carbocycle or heterocycle, wherein the heterocycle can contain up to three different or same heteroatoms O, N, S, and wherein the cycle formed can optionally be substituted or a further, optionally substituted cycle can be condensed onto this cycle;

R W 1 :

hydrogen, OH, halogen, NO 2 , NH 2 , CN, CF 3 , CHF 2 , O—CF 3 , O—CHF 2 , or each optionally substituted C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 1 -C 6 -alkylene-O—C 1 -C 6 -alkyl, C 1 -C 6 -thioalkyl, aryl, hetaryl, O—C 1 -C 6 -alkyl, O-aryl, O-benzyl, C 1 -C 6 -alkylamino, C 1 -C 6 -dialkylamino, pyrrolidinyl, piperidinyl, morpholinyl, CO—C 1 -C 6 -alkyl, SO 2 —C 1 -C 6 -alkyl, CO-aryl, SO 2 -aryl, CO—C 1 -C 4 -alkylene-aryl, SO 2 —C 1 -C 4 -alkylene-aryl, SO-aryl, CONH 2 , CONH—C 1 -C 6 -alkyl, SO 2 NH—C 1 -C 6 -alkyl, CON—(C 1 -C 6 -alkyl) 2 , SO 2 N—(C 1 -C 6 -alkyl) 2 , NH—SO 2 —C 1 -C 6 -alkyl or NH—CO—C 1 -C 6 -alkyl;

as moiety A is defined;

each optionally substituted C 1-4 -alkylene or C 1-4 -alkyleneoxy;

R 1 , R 2 , R 3 independently of one another:

hydrogen, OH,

each optionally substituted C 1 -C 6 -alkyl, O—C 1 -C 6 -alkyl, C 1 -C 6 -alkylene-O—C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, O—C 3 -C 7 -cycloalkyl, aryl, hetaryl, C 1 -C 4 -alkylene-aryl, C 1 -C 4 -alkylene-hetaryl, O-aryl, O—C 1 -C 4 -alkylene-aryl, O-hetaryl, O—C 1 -C 4 -alkylene-hetaryl, CO—C 1 -C 6 -alkyl, CO-aryl, CO-hetaryl, CO—C 1 -C 4 -alkylene-aryl, CO—C 1 -C 4 -alkylene-hetaryl, CO—O—C 1 -C 6 -alkyl, CO—O-aryl, CO—O-hetaryl, CO—O—C 1 -C 4 -alkylene-aryl, SO 2 —C 1 -C 6 -alkyl, SO 2 -aryl, SO 2 -hetaryl, SO 2 —C 1 -C 4 -alkylene-aryl, OCO—C 1 -C 6 -alkyl, OCO-aryl, OCO-hetaryl, OCO—C 1 -C 4 -alkylene-aryl, OCO—C 1 -C 4 -alkylene-hetaryl, SO 2 —C 1 -C 6 -alkyl, SO 2 -aryl, SO 2 -hetaryl or SO 2 —C 1 -C 4 -alkylene-aryl, or

each independent from the third moiety two moieties of R 1 , R 2 or R 3 together form a 5 to 7-membered, optionally substituted, saturated or unsaturated carbocycle or an optionally substituted, saturated or unsaturated heterocycle which can contain one, two or three further different or same heteroatoms from the group O, N, S, wherein optionally two moieties substituted on this carbo- or heterocycle together can form an anellated, saturated, unsaturated or aromatic carbocycle or heterocycle, wherein the heterocycle can contain up to three different or same heteroatoms O, N, S, and wherein the cycle formed can be optionally substituted or a further, optionally substituted cycle can be condensed onto this cycle;

a doubly substituted 5-membered hetaryl moiety of formula Q1

E: S;

R Q 1 :

hydrogen or

each optionally substituted C 1 -C 4 -alkyl, CO—C 1 -C 4 -alkyl, SO 2 —C 1 -C 4 -alkyl, CO—O—C 1 -C 4 -alkyl, aryl, C 1 -C 4 -alkylene-aryl, CO-aryl, CO-hetaryl, SO 2 -aryl, SO 2 -hetaryl, CO—O-aryl, CO—C 1 -C 4 -alkylene-aryl, SO 2 —C 1 -C 4 -alkylene-aryl or CO—O—C 1 -C 4 -alkylene-aryl;

R 4 , R 5 each independently of one another a moiety chosen from the groups 1), 2), 3), 4), 5), 6) or 7):

1) hydrogen, halogen, CN, CF 3 , CHF 2 , or

each optionally substituted C 1 -C 10 -alkyl, C 2 -C 10 -alkenyl, C 2 -C 10 -alkynyl, C 3 -C 7 -cycloalkyl, C 1 -C 6 -alkylene-C 3 -C 7 -cycloalkyl, C 1 -C 4 -alkylene-aryl, C 1 -C 4 -alkylene-hetaryl, C 1 -C 6 -alkylene-O—C 1 -C 6 -alkyl, C 1 -C 6 -alkylene-O-aryl, COO—C 1 -C 4 -alkyl or C 1 -C 4 -alkylene-COO—C 1 -C 4 -alkyl;

2) Phenyl or naphthyl, which are each substituted with R Q 2 , R Q 3 and R Q 4 , wherein

R Q 2 , R Q 3 and R Q 4 each independently of one another represent a substituent from the following group:

hydrogen, NO 2 , NH 2 , OH, CN, CF 3 , CHF 2 , OCF 3 , OCHF 2 , COOH, O—CH 2 —COOH, SH, halogen, or

each optionally substituted aryl, hetaryl, heterocycloalkyl, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 7 -cycloalkyl, C 1 -C 4 -alkylene-C 3 -C 7 -cycloalkyl, C 1 -C 4 -alkylene-heterocycloalkyl, C 1 -C 4 -alkylene-aryl or C 1 -C 4 -alkylene-hetaryl, or

O—R Q 5 , S—R Q 5 , NR Q 7 R Q 8 , CO—OR Q 6 , NR Q 8 —COO—O—R Q 6 , O—CH 2 —COO—R Q 6 , NR Q 8 —CO—R Q 6 , SO 2 —R Q 6 , NR Q 8 —SO 2 —R Q 6 , SO 2 NH 2 , CONH 2 , SO 2 —NR Q 7 R Q 8 or CO—NR Q 7 R Q 8 , or

two of the moieties R Q 2 , R Q 3 or R Q 4 together form a 3 to 7-membered, optionally substituted, saturated, unsaturated or aromatic carbocycle or a an optionally substituted, saturated, unsaturated aromatic heterocycle which can contain up to three further different or same heteroatoms O, N, S and optionally two of the moieties substituted on this heterocycle can together form an anellated, saturated, unsaturated or aromatic carbocycle or heterocycle, wherein the heterocycle can contain up to three different or same heteroatoms O, N, S and the cycle formed can be optionally substituted or a further, optionally substituted cycle can be condensed onto this cycle;

R Q 5 each optionally substituted C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 1 -C 4 -alkylene-C 3 -C 7 -cycloalkyl, C 1 -C 4 -alkylene-heterocycloalkyl, heterocycloalkyl or hetaryl, or

C 1 -C 6 -alkyl, which is optionally substituted with a substituent from the group consisting of halogen, NO 2 , NH 2 , OH, CN, CF 3 , CHF 2 , OCF 3 , OCHF 2 , NH—(C 1 -C 6 -alkyl) and N(C 1 -C 6 -alkyl) 2 ;

R Q 6 each optionally substituted C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 7 -cycloalkyl, C 1 -C 4 -alkylene-C 3 -C 7 -cycloalkyl, C 1 -C 4 -alkylene-heterocycloalkyl, aryl, hetaryl, heterocycloalkyl or C 1 -C 6 -alkylene-O—C 1 -C 6 -alkyl;

R Q 7 hydrogen, OH, CN, or

each optionally substituted C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 7 -cycloalkyl, C 1 -C 4 -alkylene-C 3 -C 7 -cycloalkyl, C 1 -C 4 -alkylene-heterocycloalkyl, aryl, hetaryl, heterocycloalkyl, C 1 -C 6 -alkylene-O—C 1 -C 6 -alkyl, CO—C 1 -C 6 -alkyl, C 1 -C 4 -alkylene-aryl, C 1 -C 4 -alkylene-hetaryl, CO-aryl, CO-hetaryl, CO—C 1 -C 4 -alkylene-aryl, CO—C 1 -C 4 -alkylene-hetaryl, CO—O—C 1 -C 6 -alkyl, CO—O-aryl, CO—O—C 1 -C 4 -alkylene-aryl, CO—O-hetaryl, CO—O—C 1 -C 4 -alkylene-hetaryl, SO 2 —C 1 -C 6 -alkyl, SO 2 -aryl, SO 2 -hetaryl, SO 2 —C 1 -C 4 -alkylene-aryl or SO 2 —C 1 -C 4 -alkylene-hetaryl;

R Q 8 hydrogen or

each optionally substituted C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 7 -cycloalkyl, C 1 -C 4 -alkylene-C 3 -C 7 -cycloalkyl, C 1 -C 4 -alkylene-heterocycloalkyl, aryl, hetaryl, heterocycloalkyl, C 1 -C 6 -alkylene-O—C 1 -C 6 -alkyl, CO—C 1 -C 6 -alkyl, CO-aryl, CO-hetaryl, CO—C 1 -C 4 -alkylene-aryl, CO—C 1 -C 4 -alkylene-hetaryl, CO—O—C 1 -C 6 -alkyl, CO—O-aryl, CO—O—C 1 -C 4 -alkylene-aryl, CO—O-hetaryl, CO—O—C 1 -C 4 -alkylene-hetaryl, SO 2 —C 1 -C 6 -alkyl, SO 2 -aryl, SO 2 -hetaryl, SO 2 —C 1 -C 4 -alkylene-aryl or SO 2 —C 1 -C 4 -alkylene-hetaryl;

or the moieties R Q 7 and R Q 8 , together with the nitrogen, form a 3 to 7-membered, optionally substituted, saturated or aromatic heterocycle, which can contain one, two or three further different or same heteroatoms O, N, S; and optionally two of the moieties substituted on this heterocycle can together form an anellated, saturated, unsaturated or aromatic carbocycle or heterocycle, wherein the heterocycle can contain up to three different or identical heteroatoms O, N, S, and the cycle formed can optionally be substituted or a further, optionally substituted cycle can be condensed onto this cycle;

3) a 5- or 6-membered hetaryl moiety optionally substituted with 1 or 2 substituents, the hetaryl moiety chosen from the group consisting of:

2-pyrrolyl, 3-pyrrolyl, 2-oxazolyl, 4-oxazolyl, 5-oxazolyl, 2-pyrimidyl, 4-pyrimidyl, 5-pyrimidyl, 6-pyrimidyl, 3-pyrazolyl, 4-pyrazolyl, 5-pyrazolyl, 3-isothiazolyl, 4-isothiazolyl, 5-isothiazolyl, 3-pyridazinyl, 4-pyridazinyl, 5-pyridazinyl, 6-pyridazinyl, 3-isoxazolyl, 4-isoxazolyl, 5-isoxazolyl, thiadiazolyl, oxadiazolyl or triazinyl or their anellated derivatives indazolyl, benzothiophenyl, benzofuranyl, indolinyl, benzimidazolyl, benzthiazolyl, benzoxazolyl, quinolinyl and isoquinolinyl; or

2-thienyl or 3-thienyl optionally substituted with one or two substituents, wherein the substituents are chosen from the group consisting of halogen, NO 2 , NH 2 , OH, CN, CF 3 , OCF 3 , CHF 2 , O—CHF 2 , C 1 -C 6 -alkyl, O—C 1 -C 6 -alkyl, NH—(C 1 -C 6 -alkyl), N(C 1 -C 6 -alkyl) 2 , NHCO—C 1 -C 4 -alkyl, NHSO 2 —C 1 -C 4 -alkyl and SO 2 —C 1 -C 4 -alkyl;

4) both moieties R 4 and R 5 together form a 4 to 7-membered, optionally substituted, saturated or unsaturated or aromatic carbocycle or a 5- or 6-membered optionally substituted, saturated or unsaturated or aromatic heterocycle, which can contain up to three further different or identical heteroatoms O, N, S; and can be substituted with up to two further moieties, wherein optionally two moieties substituted on this carbo or hetero cycle can together form an anellated, saturated, unsaturated or aromatic carbo cycle or heterocycle, wherein the heterocycle can contain up to three different or identical heteroatoms O, N, S and wherein the cycle formed can be optionally substituted or a further, optionally substituted cycle can be condensed onto this cycle;

5) a C 5 -C 18 -bi- or tricyclic, saturated hydrocarbon moiety;

6) each optionally substituted C 1 -C 8 -Alkyl-NH 2 , C 1 -C 8 -Alkyl-NR Q 7 R Q 8 , C 1 -C 8 -Alkyl-CO—NR Q 7 R Q 8 , C 1 -C 8 -Alkyl-SO 2 NR Q 7 R Q 8 , C 1 -C 8 -Alkyl-CO—NH 2 , C 1 -C 8 -Alkyl-SO 2 NH 2 , CO—NH 2 , CO—NR Q 7 R Q 8 , SO 2 NH 2 , SO 2 NR Q 7 R Q 8 , NR Q 7 R Q 8 ;

7) a 4-7-membered monocyclic saturated heterocycle or bicyclic saturated or unsaturated heterocycle, which can contain up to two different or identical heteroatoms from the group O, N or S, wherein this cycle can also be multiply substituted; for the case that the heterocycle contains an N-atom, this can be substituted with a moiety R Q 7 .

2. A guanidine compound of the formula I

corresponding enantiomeric, diastereomeric and/or tautomeric forms thereof as well as pharmaceutically acceptable salts thereof, wherein the given moieties have the following definitions:

a moiety of the formula W1

wherein

NO 2 , NH 2 , OH, CN, CF 3 , OCF 3 , CHF 2 , OCHF 2 , COOH, O—CH 2 —COOH, halogen, SH, or

O—R A 1 , CO—R A 1 , SO—R A 1 , SO—R A 1 , CO—O—R A 1 , NR A 4 —CO—O—R A 1 , O—CH 2 —COO—R A 1 , NR A 2 R A 3 , CONH 2 , SO 2 NH 2 , NR A 4 —CO—R A 1 , SO 2 —R A 1 , NR A 4 —SO 2 —R A 1 , SO 2 —NR A 2 R A 3 or CO—NR A 2 R A 3 ;

R A 1 :

R A 2 :

hydrogen, OH, CN, or

R A 3 :

or the moieties R A 2 and R A 3 form, together with the nitrogen, a 3 to 7-membered, optionally substituted, saturated or aromatic heterocycle, which can contain one, two or three further different or identical heteroatoms from the group O, N, S; wherein optionally two of the moieties substituted on this heterocycle can together form an anellated, saturated, unsaturated or aromatic carbocycle or heterocycle, wherein the heterocycle can contain up to three different or identical heteroatoms O, N, S and wherein the so-formed cycle can be optionally substituted or a further, optionally substituted cycle can be condensed onto this cycle;

R A 4 :

hydrogen, or

hydrogen or as moiety A is defined,

or each independently of one another, two of the moieties A, B or R w 1 together form a 3 to 7-membered, optionally substituted, saturated or unsaturated carbocycle or an optionally substituted, saturated or unsaturated or aromatic heterocycle which can contain one, two or three further different or identical heteroatoms from the group O, N, S; wherein optionally two moieties substituted on this carbo- or heterocycle can together form an anellated, saturated, unsaturated or aromatic carbocycle or heterocycle, wherein the heterocycle can contain up to three different or identical heteroatoms O, N, S and wherein the cycle formed can optionally be substituted or a further, optionally substituted cycle can be condensed onto this cycle;

R W 1 :

as moiety A is defined;

each optionally substituted C 1-4 -alkylene or C 1-4 -alkyleneoxy;

R 1 , R 2 , R 3 independently of one another:

hydrogen, OH, or

each independently of the third moiety, two moieties of R 1 , R 2 or R 3 together form a 5 to 7-membered, optionally substituted, saturated or unsaturated carbocycle or an optionally substituted, saturated or unsaturated heterocycle which can contain one, two or three further different or identical heteroatoms from the group O, N, S, wherein optionally two of the moieties substituted on this carbo- or heterocycle can together form an anellated, saturated, unsaturated or aromatic carbocycle or heterocycle wherein the heterocycle can contain up to three different or identical heteroatoms O, N, S and wherein the cycle formed is optionally substituted or a further, optionally substituted cycle is condensed onto this cycle;

a doubly substituted 5-membered hetaryl moiety of formula Q1

E: S;

R Q 1 :

hydrogen, or

R 4 , R 5 each independently of one another a moiety chosen from the groups 1), 2), 3), 4) or 5):

1) hydrogen, halogen, CN, CF 3 , CHF 2 , or

2) Phenyl or naphthyl, which are each substituted with R Q 2 , R Q 3 and R Q 4 , wherein

R Q 2 , R Q 3 and R Q 4 each independently of one another represent a substituent from the following group:

hydrogen, NO 2 , NH 2 , OH, CN, CF 3 , CHF 2 , OCF 3 , OCHF 2 , COOH, O—CH 2 —COOH, SH, halogen, or

O—R Q 5 , S—R Q 5 , NR Q 7 R Q 8 , CO—OR Q 6 , NR Q 8 —CO—R Q 6 , O—CH 2 —COO—R Q 6 , NR Q 8 —CO—R Q 6 , SO 2 —R Q 6 , NR Q 8 —SO 2 —R 6 , SO 2 NH 2 , CONH 2 , SO 2 —NR Q 7 R Q 8 or CO—NR Q 7 R Q 8 or

two of the moieties R Q 2 , R Q 3 or R Q 4 together form a 3 to 7-membered, optionally substituted, saturated, unsaturated or aromatic carbocycle or an optionally substituted, saturated or unsaturated aromatic heterocycle, which can contain up to three further different or identical heteroatoms O, N, S and optionally two moieties substituted on this heterocycle can together form an anellated, saturated, unsaturated or aromatic carbocycle or heterocycle, wherein the heterocycle can contain up to three different or identical heteroatoms O, N, S and the cycle formed can optionally be substituted or a further, optionally substituted cycle can be condensed onto this cycle;

R Q 5 each optionally substituted C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 1 -C 4 -alkylene-C 3 -C 7 -cycloalkyl, C 1 -C 4 -alkylene-heterocycloalkyl, heterocycloalkyl or hetaryl, or C 1 -C 6 -alkyl, which is optionally substituted with a substituent from the group consisting of halogen, NO 2 , NH 2 , OH, CN, CF 3 , CHF 3 , OCF 3 , OCHF 2 , NH—(C 1 -C 6 -alkyl) and N(C 1 -C 6 -alkyl) 2 ;

R Q 7 hydrogen, OH, CN, or

R Q 8 each optionally substituted C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 7 -cycloalkyl, C 1 -C 4 -alkylene-C 3 -C 7 -cycloalkyl, C 1 -C 4 -alkylene-heterocycloalkyl, aryl, hetaryl, heterocycloalkyl, C 1 -C 6 -alkylene-O—C 1 -C 6 -alkyl, CO—C 1 -C 6 -alkyl, CO-aryl, CO-hetaryl, CO—C 1 -C 4 -alkylene-aryl, CO—C 1 -C 4 -alkylene-hetaryl, CO—O—C 1 -C 6 -alkyl, CO—O-aryl, CO—O—C 1 -C 4 -alkylene-aryl, CO—O-hetaryl, CO—O—C 1 -C 4 -alkylene-hetaryl, SO 2 —C 1 -C 6 -alkyl, SO 2 -aryl, SO 2 -hetaryl, SO 2 —C 1 -C 4 -alkylene-aryl or SO 2 —C 1 -C 4 -alkylene-hetaryl;

or the moieties R Q 7 and R Q 8 form, together with the nitrogen, a 3 to 7-membered, optionally substituted, saturated or aromatic heterocycle which can contain one, two or three further or different identical heteroatoms O, N, S; and optionally two moieties substituted on this heterocycle can form an anellated, saturated, unsaturated or aromatic carbocycle or heterocycle, wherein the heterocycle can contain up to three different or identical heteroatoms O, N, S and the cycle formed can optionally be substituted or a further, optionally substituted cycle can be condensed onto this cycle;

3) a 5- or 6-membered hetaryl moiety optionally substituted with one or two substituents from the group consisting of:

2-pyrrolyl, 3-pyrrolyl, 2-thiazolyl, 4-thiazolyl, 5-thiazolyl, 2-oxazolyl, 4-oxazolyl, 5-oxazolyl, 2-pyrimidyl, 4-pyrimidyl, 5-pyrimidyl, 6-pyrimidyl, 3-pyrazolyl, 4-pyrazolyl, 5-pyrazolyl, 3-isothiazolyl, 4-isothiazolyl, 5-isothiazolyl, 2-imidazolyl, 4-imidazolyl, 5-imidazolyl, 3-pyridazinyl, 4-pyridazinyl, 5-pyridazinyl, 6-pyridazinyl, 3-isoxazolyl, 4-isoxazolyl, 5-isoxazolyl, thiadiazolyl, oxadiazolyl or triazinyl or their anellated derivatives indazolyl, benzothiophenyl, benzofuranyl, indolinyl, benzimidazolyl, benzthiazolyl, benzoxazolyl, quinolinyl and isoquinolinyl; or

4) both moieties R 4 and R 5 together form a 4 to 7-membered, optionally substituted, saturated or unsaturated or aromatic carbocycle or a 5- or 6-membered optionally substituted, saturated or unsaturated or aromatic heterocycle, which can contain up to three further different or identical heteroatoms O, N, S and can be substituted with up to two further moieties, wherein optionally two moieties substituted on this carbo- or heterocycle can form an anellated, saturated, unsaturated or aromatic carbocycle or heterocycle, wherein the heterocycle can contain up to three different or identical heteroatoms O, N, S and wherein the cycle formed can be optionally substituted or a further, optionally substituted cycle can be condensed onto this cycle;

5) a C 5 -C 1 — bi- or tricyclic, saturated hydrocarbon moiety.

3. The compound according to claim 1 , wherein the given moieties have the following definition:

W: W1;

A: halogen, OH, CN, CF 3 , CHF 2 , OCF 3 , OCHF 2 , or

each optionally substituted C 1 -C 6 -alkyl or C 2 -C 6 -alkenyl,

O—CH 2 —COO—R A 1 , O—R A 1 , S—R A 1 , NR A 2 R A 3 , NR A 4 —CO—R A 1 or CO—NR A 4 R A 1 ;

R A 1 : each optionally substituted C 1 -C 4 -alkyl, C 3 -C 7 -cycloalkyl, phenyl or benzyl;

R A 2 : hydrogen, or

each optionally substituted C 1 -C 4 -alkyl, phenyl, benzyl, phenethyl, CO—C 1 -C 4 -alkyl, CO-aryl, CO—O—C 1 -C 4 -alkyl, SO 2 —C 1 -C 4 -alkyl, SO 2 -aryl, SO 2 -hetaryl or SO 2 —C 1 -C 4 -alkylene-aryl;

R A 3 : each optionally substituted C 1 -C 4 -alkyl, phenyl, benzyl, phenethyl, CO—C 1 -C 4 -alkyl, CO-aryl, CO—O—C 1 -C 4 -alkyl, SO 2 —C 1 -C 4 -alkyl, SO 2 -aryl, SO 2 -hetaryl, or SO 2 —C 1 -C 4 -alkylene-aryl;

or the moieties R A 2 and R A 3 together form an optionally substituted 5- or 6-membered saturated or unsaturated ring, which can contain up to two identical or different heteroatoms from the group O and N;

R A 4 : hydrogen or an optionally substituted C 1 -C 4 -alkyl moiety;

B: hydrogen or as moiety A is defined;

R W 1 : hydrogen, F, Cl, CN, CF 3 , O—CF 3 , or

each optionally substituted C 1 -C 4 -alkyl, aryl, C 1 -C 6 -alkylamino or C 1 -C 6 -dialkylamino;

R 1 , R 2 , R 3 independently of one another:

hydrogen, OH, C 1 -C 4 -alkyl, C 1 -C 6 -alkylene-O—C 1 -C 6 -alkyl, substituted aryl, benzyl, CO—C 1 -C 6 -alkyl, CO-aryl, CO—C 1 -C 4 -alkylene-aryl, OCO—C 1 -C 6 -alkyl, OCO-aryl or OCO—C 1 -C 4 -alkylene-hetaryl;

Q is Q1;

R Q 1 : hydrogen, optionally substituted C 1 -C 4 -alkyl, in the aryl moiety optionally substituted benzyl, CO—C 1 -C 4 -alkyl, optionally substituted benzoyl, SO 2 —C 1 -C 4 -alkyl or in the aryl moiety optionally substituted SO 2 -aryl.

4. The compound according to claim 1 , wherein the given moieties have the following definitions:

A: OH, F, Cl, OCF 3 , OCHF 2 , optionally substituted C 1 -C 4 -alkyl, O—C 1 -C 4 -alkyl or S—C 1 -C 4 -alkyl;

B: hydrogen, OH, F, Cl, CF 3 , OCF 3 , OCHF 2 , optionally substituted C 1 -C 4 -alkyl, O—C 1 -C 4 -alkyl or S—C 1 -C 4 -alkyl;

R W 1 : hydrogen, F, Cl, CN, CF 3 or O—CF 3 ;

R 1 , R 2 , R 3 independently of one another:

hydrogen, OH, O-methyl, O-phenyl, acetyl, benzoyl, O-acetyl, or O-benzoyl;

Q is chosen from the group consisting of

R Q 1 : hydrogen, CH 3 , methanesulfonyl, phenylsulfonyl or tosyl.

5. The compound according to claim 1 , wherein the given moieties have the following definitions:

A: OH, OCF 3 , OCH 3 , O-ethyl, O-propyl or O-i-propyl;

Z: —CH 2 —, —CH 2 —O—, —CH 2 —CH 2 — or —CH 2 —CH 2 —O—;

two of the moieties R 1 , R 2 , or R 3 , are hydrogen, and the third moiety is hydrogen, OH, acetyl or benzoyl;

6. The compound according to claim 1 , wherein R 4 and/or R 5 each independently of one another represents a moiety chosen from the groups 1), 2), 3), 4) or 5):

1) hydrogen, F, Cl, CN, CF 3 , or

each optionally substituted C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 1 -C 6 -alkylene-O—C 1 -C 6 -alkyl or C 3 -C 7 -cycloalkyl;

2) Phenyl or naphthyl, which are each substituted with R Q 2 , R Q 3 , and R Q 4 , wherein

R Q 2 , R Q 3 , and R Q 4 each independently of one another represent a substituent from the following group:

hydrogen, CN, CF 3 , CHF 2 , OCF 3 , OCHF 2 , F, Cl, OH or

each optionally substituted phenyl or hetaryl, C 1 -C 4 -alkyl, C 5 -C 7 -cycloalkyl, O—R Q 5 , NR Q 7 R Q 8 , CO—OR Q 6 , NR Q 8 —CO—O—R Q 6 , O—CH 2 —COO—R Q 6 , NR Q 8 —CO—R Q 6 , SO 2 —R Q 6 , NR Q 8 —SO 2 —R Q 6 , NR Q 8 —CO—O—R Q 6 , SO 2 NH 2 , CONH 2 , SO 2 —NR Q 7 R Q 8 or CO—NR Q 7 R Q 8 ;

R Q 5 : C 1 -C 4 -Alkyl, which is optionally substituted with a substituent from the group consisting of F, Cl, OH, CN, CF 3 , OCF 3 , NH—(C 1 -C 4 -alkyl) and N(C 1 -C 4 -alkyl) 2 ;

R Q 6 : each optionally substituted C 1 -C 6 -alkyl, aryl, hetaryl or phenyl;

R Q 7 : hydrogen, each optionally substituted C 1 -C 4 -alkyl, allyl, aryl, hetaryl, benzyl, phenethyl or CH 2 -hetaryl;

R Q 8 , each optionally substituted C 1 -C 4 -alkyl, allyl, aryl, hetaryl, benzyl, phenethyl or CH 2 -hetaryl;

or R Q 7 and R Q 8 form an optionally substituted 3- or 7-membered saturated or unsaturated ring which can contain up to two identical or different hetero atoms from the group O and N;

3) benzothiophenyl, benzofuranyl, quinolinyl and isoquinolinyl;

4) both moieties R 4 and R 5 together form one of the following rings:

wherein R Q 2 and R Q 3 are as defined under 2);

5) Adamantyl.

7. The compound according to claim 1 , wherein the given moieties have the following definitions:

W: W1;

A: halogen, OH, CN, CF 3 , CHF 2 , OCF 3 , OCHF 2 , or

each optionally substituted C 1 -C 6 -alkyl or C 2 -C 6 -alkenyl,

O—CH 2 —COO—R A 1 , O—R A 1 , S—R A 1 , NR A 2 R A 3 , NR A 4 —CO—R A 1 , SO 2 NH 2 , NR A 4 —SO 2 —R A 1 , SO 2 —NR A 2 R A 3 or CO—NR A 4 R A 1 ;

R A 1 : each optionally substituted C 1 -C 4 -alkyl, C 3 -C 7 -cycloalkyl, phenyl or benzyl;

R A 2 : hydrogen, or

R A 4 : hydrogen or an optionally substituted C 1 -C 4 -alkyl moiety;

B: hydrogen or as moiety A is defined;

R W 1 : hydrogen, F, Cl, CN, CF 3 , O—CF 3 , or

each optionally substituted C 1 -C 4 -alkyl, aryl, C 1 -C 6 -alkylamino or C 1 -C 6 -dialkylamino;

R 1 , R 2 , R 3 independently of one another:

Q is Q1;

8. The compound according to claim 1 , wherein the given moieties have the following definitions:

A: OH, F, Cl, OCF 3 , OCHF 2 , optionally substituted C 1 -C 4 -alkyl, O—C 1 -C 4 -alkyl or S—C 1 -C 4 -alkyl;

B: hydrogen, OH, F, Cl, CF 3 , OCF 3 , OCHF 2 , optionally substituted C 1 -C 4 -alkyl, O—C 1 -C 4 -alkyl or S—C 1 -C 4 -alkyl;

R W 1 : hydrogen, F, Cl, CN, CF 3 or O—CF 3 ;

R 1 , R 2 , R 3 independently of one another:

hydrogen, OH, O-methyl, O-phenyl, acetyl, benzoyl, O-acetyl, or O-benzoyl;

Q is

R Q 1 : hydrogen, CH 3 , phenyl, benzyl, methanesulfonyl, phenylsulfonyl or tosyl.

9. The compound according to claim 1 , wherein the given moieties have the following definitions:

A: OH, OCF 3 , OCH 3 , O-ethyl, O-propyl or O-i-propyl;

Z: —CH 2 —, —CH 2 —O—, —CH 2 —CH 2 — or —CH 2 —CH 2 —O—;

two of the moieties R 1 , R 2 , or R 3 are hydrogen, and the third moiety is hydrogen, OH, acetyl or benzoyl;

R Q 1 : hydrogen, CH 3 , phenyl, benzyl, methanesulfonyl, phenylsulfonyl or tosyl.

10. Guanidine compound according to claim 1 , wherein R 4 and/or R 5 each independently from one another represent a moiety chosen from the groups 1), 2), 3), 4), 5) or 6):

1) hydrogen, F, Cl, CN, CF 3 , or

each optionally substituted C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 1 -C 6 -alkylene-O—C 1 -C 6 -alkyl or C 3 -C 7 -cycloalkyl;

2) Phenyl or naphthyl, which are each substituted with R Q 2 , R Q 3 , and R Q 4 , wherein

R Q 2 , R Q 3 , and R Q 4 each independently of one another represent a substituent from the following group:

hydrogen, CN, CF 3 , CHF 2 , OCF 3 , OCHF 2 , F, Cl, OH or

R Q 5 : C 1 -C 4 -alkyl, which is optionally substituted with a substituent from the group consisting of F, Cl, OH, CN, CF 3 , OCF 3 , NH—(C 1 -C 4 -alkyl) and N(C 1 -C 4 -alkyl) 2 ;

R Q 6 : each optionally substituted C 1 -C 6 -alkyl, aryl, hetaryl or phenyl;

R Q 7 , hydrogen, each optionally substituted C 1 -C 4 -alkyl, allyl, aryl, hetaryl, benzyl, phenethyl or CH 2 -hetaryl;

R Q 8 , hydrogen, each optionally substituted C 1 -C 4 -alkyl, allyl, aryl, hetaryl, benzyl, phenethyl or CH 2 -hetaryl;

or R Q 7 and R Q 8 form an optionally substituted 3- or 7-membered saturated or unsaturated ring, which can contain up to two identical or different heteroatoms from the group O and N;

3) benzothiophenyl, benzofuranyl, quinolinyl and isoquinolinyl;

4) both moieties R 4 and R 5 together form one of the following rings:

wherein R Q 2 and R Q 3 are defined as under 2); or together can form an anellated 5- or 6-membered ring;

5) adamantyl;

6) each optionally substituted azetidine-3-yl, pyrrolidine-2-yl, pyrrolidine-3-yl, piperidine-2-yl, piperidine-3-yl, piperidine-4-yl, tetrahydro-2H-pyrane-4-yl, tetrahydrofuran-3-yl, azepan-4-yl, azepan-3-yl, azepan-2-yl, 1,4-diazepane-5-yl, 1,2,3,6-tetrahydropyridine-4-yl, or 2,5-dihydro-1H-pyrrol-3-yl.

11. The compound according to claim 1 , wherein one moiety from R 4 and R 5 is chosen from group 1), and the other moiety from R 4 and R 5 is chosen from the group 1), 2) or 3).

12. A pharmaceutical composition, comprising at least one guanidine compound according to claim 1 , as well as a pharmaceutically acceptable carrier or dilution agent.

Assignments (2)

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 16, 2013

From: ABBOTT GMBH & CO KG

To: ABBVIE DEUTSCHLAND GMBH & CO KG

Reel/Frame 030804/0429 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 14, 2007

From: NETZ, ASTRID; AMBERG, WILHELM; LANGE, UDO; OCHSE, MICHAEL; HUTCHINS, CHARLES W.; GARCIA-LADONA, FRANCISCO-XAVIER; WERNET, WOLFGANG; KLING, ANDREAS

To: ABBOTT GMBH & CO., KG

Reel/Frame 019819/0707 →