Pegylation and hydroxylation of trimetallic nitride endohedral metallofullerenes
View Patent ↗A pegylated and hydroxlated trimetallic nitride endohedral metallofullerene is provided comprising a plurality of hydroxyl groups and one or more polyethylene glycol (PEG) moieties covalently bonded to a fullerene encapsulating a trimetallic nitride. Methods of pegylation and hydroxylation of trimetallic nitride endohedral metallofullerene and methods of using pegylated and hydroxlated trimetallic nitride endohedral metallofullerene are described.
1. An endohedral metallofullerene of the formula: A 3−n X n N@C m (—R(—[—O—CH 2 CH 2 —] k —Q) j ) i (—OH) h ; where A and X are metal atoms, n=0−3; m is an even number between about 60 and about 200; 1<h<m−2; i≧1; j=1 or 2; and k>1 wherein R is a malonyl group or an ethyl-malonyl group and Q is a methoxy group or a functional group selected from among an antigen, an antibody fragment, a membrane anchoring sequence, a polynucleotide, a receptor ligand, and biotin.
2. The endohedral metallofullerene of claim 1 , wherein j=1 and R is an ethyl malonyl group.
3. The endohedral metallofullerene of claim 1 , wherein Q is a methoxy group.
4. The endohedral metallofullerene of claim 1 , wherein j=2 and R is a malonyl group.
5. The endohedral metallofullerene of claim 1 , wherein k is about 7.
6. The endohedral metallofullerene of claim 1 , wherein k is about 1.
7. The endohedral metallofullerene of claim 1 , wherein k is about 16 or greater.
8. The endohedral metallofullerene of claim 1 , wherein k is about 40 or greater.
9. The endohedral metallofullerene of claim 1 , wherein, A and/or X are rare earth element and/or a group IIIB element.
10. The endohedral metallofullerene of claim 1 , wherein A and/or X are chosen from among the group consisting of Scandium, Yttrium, Lanthanum, Gadolinium, Holmium, Erbium, Thulium, and Ytterbium.