Use of a phenothiazine derivative for preventing and/or treating hearing loss
View Patent ↗The invention concerns the use of a phenothiazine derivative of formula (I), wherein: R represents the hydrogen atom, an alkyl radical, arylalkyl, or —C(O)R′, for preparing a medicine for preventing and/or treating hearing loss.
1. A method of protecting acoustic hair cells comprising administering to a patient in need thereof a heterocyclic derivative of formula
diastereoisomers of derivative (I), or combinations thereof,
wherein R is a (C 1 -C 6 ) alkyl, aryl alkyl or —C(O)R′ radicals;
wherein R′ is a (C 1 -C 6 ) alkyl or aralkyl radical;
the alkyl or aryl radicals being optionally substituted by one or more identical or different substituents including: (C 1 -C 6 ) alkyl, hydroxy, (C 1 -C 6 ) alkoxy, nitro, cyano, halogen or —NR 1 R 2 ;
wherein R 1 and R 2 are independently, a hydrogen atom or an (C 1 -C 6 )alkyl radical.
2. The method of claim 1 , wherein R is —C(O)R′.
3. The method of claim 2 , wherein R′ is an alkyl radical.
4. The method of claim 3 , wherein R is —C(O)—CH 3 .
5. The method of claim 1 , wherein the derivative (I) has the formula
6. The method of claim 1 , wherein the derivative (I) has the formula
7. The method of claim 1 , wherein the derivative (I) has the formula
8. The method of claim 1 , wherein the derivative (I) has the formula
9. The method of claim 1 , wherein the derivative (I) has the formula
10. The method of claim 1 , wherein the derivative (I) has the formula
11. The method of claim 1 , wherein the derivative is administered following the administration of a medicament, wherein the medicament comprises antibiotics, anti-cancer drugs, non-steroidal anti-inflammatory agents, diuretics, antiulceratives, anticonvulsant agents, or combinations thereof.
12. The method of claim 11 , wherein the medicament is an antibiotic.
13. The method of claim 12 , wherein the antibiotic is gentamicin.
14. The method of claim 1 , wherein said method protects acoustic hair cells following presbycusis.
15. The method of claim 1 , further comprising administering at least one other substance with pharmaceutical activity which is able to treat hearing loss or to treat any pathologies associated with hearing loss.
16. The method of claim 15 , wherein the other substance with pharmaceutical activity includes: antioxidants, calpain inhibitors, peripheral vasodilitators, agonists or antagonists of the NMDA receptor, peptide inhibitors of c-Jun N-terminal kinase or combinations thereof.
17. A method of treating hearing loss comprising administering, to a patient in need thereof up to 24 hours following an acoustic traumatism, a heterocyclic derivative of formula
diastereoisomers of derivative (I), or combinations thereof,
wherein R is a (C 1 -C 6 ) alkyl, aryl alkyl or —C(O)R′ radical;
wherein R′ is a (C 1 -C 6 ) alkyl or aralkyl radical;
the alkyl or aryl radicals being optionally substituted by one or more identical or different substituents including: (C 1 -C 6 ) alkyl, hydroxy, (C 1 -C 6 ) alkoxy, nitro, cyano, halogen or —NR 1 R 2 ;
wherein R 1 and R 2 are independently, a hydrogen atom or an (C 1 -C 6 )alkyl radical.
18. The method of claim 17 , wherein R is —C(O)R′.
19. The method of claim 18 , wherein R′ is an alkyl radical.
20. The method of claim 18 , wherein R is —C(O)—CH 3 .
21. The method of claim 17 , wherein the derivative (I) has the formula
22. The method of claim 17 , wherein the derivative (I) has the formula
23. The method of claim 17 , wherein the derivative (I) has the formula
24. The method of claim 17 , wherein the derivative (I) has the formula
25. The method of claim 17 , wherein the derivative (I) has the formula
26. The method of claim 17 , wherein the derivative (I) has the formula
27. The method of claim 17 , wherein the derivative (I) is administered 12 hours following an acoustic traumatism.
28. The method of claim 17 , wherein the derivative (I) is administered 7 hours following an acoustic traumatism.
29. The method of claim 1 , wherein the derivative is administered following the administration of a medicament, wherein the medicament comprises antibiotics, anti-cancer drugs, non-steroidal anti-inflammatory agents, diuretics, antiulceratives, anticonvulsant agents, or combinations thereof.
30. The method of claim 29 , wherein the antibiotic is gentamicin.
31. The method of claim 17 , further comprising administering at least one other substance with pharmaceutical activity comprising antioxidants, calpain inhibitors, peripheral vasodilitators, agonists or antagonists of the NMDA receptor, peptide inhibitors of c-Jun N-terminal kinase or combinations thereof.