Method Of Screening Molecule Associated With Psychiatric Disorder
A method for screening a gene relating to a psychiatric disorder such as schizophrenia, which comprises the step of using a nematode behaviorally sensitized with amphetamine, methamphetamine, apomorphine, cocaine or the like for screening of a gene relating to the behavioral sensitization, and a method for screening a substance useful for prophylactic and/or therapeutic treatment of a psychiatric disorder, which comprises the step of using a nematode behaviorally sensitized with amphetamine, methamphetamine, apomorphine, cocaine or the like for screening of a substance that affects the behavioral sensitization.
1 . A method for screening a gene relating to a psychiatric disorder, which comprises using a behaviorally sensitized nematode for screening of a gene relating to the behavioral sensitization.
2 . A method for screening a substance useful for prophylactic and/or therapeutic treatment of a psychiatric disorder, which comprises using a behaviorally sensitized nematode for screening of a substance that affects the behavioral sensitization.
3 . The screening method according to claim 1 , wherein the psychiatric disorder is schizophrenia.
4 . The screening method according to claim 1 , wherein a nematode behaviorally sensitized by a central nervous system stimulant or another dopamine agonist is used.
5 . The screening method according to claim 4 , wherein a nematode behaviorally sensitized by any of a psychostimulant, an apomorphine, and a narcotic analgesic is used.
6 . The screening method according to claim 5 , wherein a nematode behaviorally sensitized by any of amphetamine, methamphetamine, apomorphine, and cocaine is used.
7 . A behaviorally sensitized nematode, which is used for screening a gene relating to a psychiatric disorder or a substance useful for prophylactic and/or therapeutic treatment of the psychiatric disorder.
8 . The behaviorally sensitized nematode according to claim 7 , wherein the psychiatric disorder is schizophrenia.
9 . The behaviorally sensitized nematode according to claim 7 , which is behaviorally sensitized by a central nervous system stimulant or another dopamine agonist.
10 . The behaviorally sensitized nematode according to claim 9 , which is behaviorally sensitized by any of a psychostimulant, an apomorphine, and a narcotic analgesic.
11 . The behaviorally sensitized nematode according to claim 10 , which is behaviorally sensitized by any of amphetamine, methamphetamine, apomorphine, and cocaine.
12 . The screening method according to claim 2 , wherein the psychiatric disorder is schizophrenia.
13 . The screening method according to claim 2 , wherein a nematode behaviorally sensitized by a central nervous system stimulant or another dopamine agonist is used.
14 . The screening method according to claim 3 , wherein a nematode behaviorally sensitized by a central nervous system stimulant or another dopamine agonist is used.
15 . The screening method according to claim 13 , wherein a nematode behaviorally sensitized by any of a psychostimulant, an apomorphine, and a narcotic analgesic is used.
16 . The screening method according to claim 15 , wherein a nematode sensitized by any of amphetamine, methamphetamine, apomorphine, and cocaine is used.
17 . The behaviorally sensitized nematode according to claim 8 , which is behaviorally sensitized by a central nervous stimulant or another dopamine agonist.
18 . The behaviorally sensitized nematode according to claim 17 , which is behaviorally sensitized by any of a psychostimulant, an apomorphine, and a narcotic analgesic.
19 . The behaviorally sensitized nematode according to claim 18 , which is behaviorally sensitized by any of amphetamine, methamphetamine, apomorphine, and cocaine.