Mechanically attached medical device coatings
The present invention relates to nanofibrous coatings on medical devices such a surgical mesh or stent, wherein the coating is mechanically attached to the device. The principal mechanism for attaching the coating is through causing the fibers to permeate and entangle with the substrate.
1. A method for attaching a fibrous coating to a substrate comprising the steps of:
providing a substrate;
coating a first side of the substrate with a fibrous coating; and
forcing at least one fiber through an opening in the substrate,
wherein the fibrous coating includes fibers formed from one or more polyolefins, polyethylene, polypropylene, linear poly(ethylenimine), cellulose acetate, grafted cellulosics, poly(L-lactic acid), poly(caprolactone), poly(ethyleneoxide), poly(hydroxyethylmethacrylate), poly(glycolic acid) or polyvinylpyrrolidone,
wherein the step of forcing at least a portion of the fibrous coating through said opening in the substrate is performed by pulling a substantially needle-like object through said opening in the substrate, wherein a portion of the fibrous coating is pulled through said opening by the needle-like object.
2. A method for attaching a fibrous coating to a substrate comprising the steps of:
providing a substrate;
coating a first side of the substrate with a fibrous coating; and
forcing at least one fiber through an opening in the substrate,
wherein the fibrous coating includes fibers formed from one or more polyolefins, polyethylene, polypropylene, linear poly(ethylenimine), cellulose acetate, grafted cellulosics, poly(L-lactic acid), poly(caprolactone), poly(ethyleneoxide), poly(hydroxyethylmethacrylate), poly(glycolic acid) or polyvinylpyrrolidone,
wherein the step of forcing at least a portion of the fibrous coating through said opening in the substrate is achieved by performing the additional steps of:
inserting a portion of at least one substantially needle-like object through said opening;
attaching at least one nanofiber to the substantially needle-like object; and
withdrawing the substantially needle-like object from said opening so that the at least one nanofiber is pulled through said opening.
3. A method for attaching a fibrous coating to a substrate comprising the steps of:
providing a substrate;
coating a first side of the substrate with a fibrous coating; and
forcing at least one fiber through an opening in the substrate,
wherein the fibrous coating includes fibers formed from one or more polyolefins, polyethylene, polypropylene, linear poly(ethylenimine), cellulose acetate, grafted cellulosics, poly(L-lactic acid), poly(caprolactone), poly(ethyleneoxide), poly(hydroxyethylmethacrylate), poly(glycolic acid) or polyvinylpyrrolidone;
applying a positively-charged fibrous coating to a first side of the substrate; and
applying a negatively-charged fibrous coating to a second side of the substrate.