Sustained release formulation for oral administration of HMG-CoA reductase inhibitor and method for the preparation thereof
View Patent ↗The sustained release formulation for oral administration of an HMG-CoA reductase inhibitor of the present invention can be easily and economically prepared and is capable of maintaining a constant drug level in blood by slowly releasing the HMG-CoA reductase inhibitor at a uniform rate for 24 hrs. Accordingly, the sustained release formulation of the present invention can be effectively used for lowering blood cholesterol and triglyceride levels.
1. A sustained release formulation for oral administration of an HMG-CoA reductase inhibitor comprising:
a spray-dried solid dispersant in the form of particles having a particle size ranging from 5 to 200 μm, wherein the solid dispersant contains the HMG-CoA reductase inhibitor, a solubilizing agent, and a stabilizing agent;
a mixture of sodium alginate and xanthan gum as a sustained release composite carrier; and
a mixture of propylene glycol ester alginate and hydroxypropyl methyl cellulose as a gel hydration accelerator.
2. The sustained release formulation of claim 1 , wherein the amount of the solubilizing agent is 0.05 to 20 weight part; the amount of the stabilizing agent is 0.01 to 0.1 weight part; the amount of the sustained release composite carrier is 3 to 30 weight part; and the amount of the gel hydration accelerator is 0.1 to 5 weight part based on 1 weight part of the HMG-CoA reductase inhibitor.
3. The sustained release formulation of claim 1 , wherein the HMG-CoA reductase inhibitor is selected from the group consisting of mevastatin, lovastatin, pravastatin, lactone of pravastatin, velostatin, simvastatin, rivastatin, fluvastatin, atorvastatin, cerivastatin and a pharmaceutically acceptable salt thereof.
4. The sustained release formulation of claim 3 , wherein the HMG-CoA reductase inhibitor is simvastatin or a pharmaceutically acceptable salt thereof.
5. The sustained release formulation of claim 1 , wherein the solubilizing agent is selected from the group consisting of d-α-tocopheryl polyethylene glycol 1000 succinate, polyoxyethylene stearic acid ester, polyethylene glycol and polyoxypropylene-polyoxypropylene block copolymer.
6. The sustained release formulation of claim 1 , wherein the stabilizing agent is selected from the group consisting of butylated hydroxy toluene, butylated hydroxy anisol, erythorbic acid and ascorbic acid.
7. The sustained release formulation of claim 1 , wherein the solid dispersant further includes a pharmaceutically acceptable solubilizing carrier.
8. The sustained release formulation of claim 1 , wherein the sustained release composite carrier includes 0.1 to 10 weight part of the xanthan gum based on 1 weight part of the sodium alginate.
9. The sustained release formulation of claim 1 , wherein the sustained release composite carrier further includes locust bean gum.
10. The sustained release formulation of claim 9 , wherein the sustained release composite carrier includes 0.1 to 5 weight part of the locust bean gum based on 1 weight part of the sodium alginate.
11. The sustained release formulation of claim 1 , wherein the gel hydration accelerator includes 0.05 to 20 weight part of the propylene glycol ester alginate based on 1 weight part of the hydroxypropyl methyl cellulose.
12. The sustained release formulation of claim 11 , wherein the hydroxypropyl methyl cellulose has a viscosity ranging from 4,000 to 100,000 cps.
13. The sustained release formulation of claim 1 , further comprising a pharmaceutically acceptable additive selected from the group consisting of a binder, a lubricating agent, a sweetening agent and an excipient.
14. A method for preparing the sustained release formulation of claim 1 , comprising the steps of:
(1) mixing a HMG-CoA reductase inhibitor, a solubilizing agent, and a stabilizing agent in a solvent to obtain a solid dispersant;
(2) homogeneously mixing the sustained release composite carrier being a mixture of sodium alginate and xanthan gum and the gel hydration accelerator being a mixture of propylene glycol ester alginate and hydroxypropyl methyl cellulose with the solid dispersant to form a first mixture;
(3) adding a pharmaceutically acceptable additive to the first mixture to form a second mixture; and
(4) dry-mixing and formulating the second mixture into a solid formulation, wherein, the solid dispersant is prepared by a spray-drying Method and is in the form of particles having a particle size ranging from 5 to 200 μm.
15. A sustained release formulation for oral administration of an HMG-CoA reductase inhibitor comprising:
a spray-dried solid dispersant in the form of particles having a particle size ranging from 5 to 200 μm, wherein the solid dispersant consists of the HMG-CoA reductase inhibitor, a solubilizing agent, and a stabilizing agent;
a mixture of sodium alginate and xanthan gum as a sustained release composite carrier; and
a mixture of propylene glycol ester alginate and hydroxypropyl methyl cellulose as a gel hydration accelerator.