Carboxylic acid derivatives, their preparation and use
View Patent ↗Carboxylic acid derivatives where R–R 6 , X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling diseases.
1. A compound having the formula:
wherein:
X is CH;
Y is oxygen;
Z is oxygen;
R is CO 2 H;
R 2 is methyl;
R 3 is methyl;
R 4 is phenyl;
R 5 is phenyl; and
R 6 is methyl,
or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , wherein said compound is an optically active enantiomer.
3. The compound of claim 2 , wherein the enantiomer is the S enantiomer.
4. The compound of claim 3 , wherein the enantiomer is the pure form of the S enantiomer.
5. The compound of claim 2 , wherein the enantiomer is the R enantiomer.
6. The compound of claim 5 , wherein the enantiomer is the pure form of the R enantiomer.
7. A pharmaceutical composition comprising a compound having the formula:
wherein:
X is CH;
Y is oxygen;
Z is oxygen;
R is CO 2 H;
R 2 is methyl;
R 3 is methyl;
R 4 is phenyl;
R 5 is phenyl;
R 6 is methyl; or a
pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
8. The composition of claim 7 , wherein said composition is suitable for oral, parenteral, or nasopharyngeal delivery.
9. The composition of claim 7 , wherein the composition is in a solid form.
10. The composition of claim 7 , wherein the composition is in a liquid form.
11. The composition of claim 7 , wherein the composition is in the form of a tablet, capsule, powder, granule, suppository, solution, colloid, ointment, cream, vapor or spray.
12. The composition of claim 7 , wherein the carrier comprises a tablet binder, filler, preservative, tablet disintegrant, flow regulator, plasticizer, wetting agent, dispersant, emulsifier, solvent, release-slowing agent, antioxidant, or propellant gas.
13. The composition of claim 7 , wherein the compound is an optically active enantiomer.
14. The composition of claim 13 , wherein the enantiomer is the S enantiomer.
15. The composition of claim 14 , wherein the enantiomer is the pure form of the S enantiomer.
16. The composition of claim 13 , wherein the enantiomer is the R enantiomer.
17. The composition of claim 16 , wherein the enantiomer is the pure form of the R enantiomer.
18. The compound