Methods and compositions for treating flaviviruses and pestiviruses
View Patent ↗A method and composition for treating a host infected with flavivirus or pestivirus comprising administering an effective flavivirus or pestivirus treatment amount of a described 1′, 2′ or 3′-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.
1. A method for the treatment of a flavivirus or pestivirus infection in a host, comprising administering to said host an anti-virally effective amount of a β-D-2′-methyl-ribofuranosyl nucleoside or a pharmaceutically acceptable salt or ester thereof.
2. The method of claim 1 , wherein the nucleoside is a pyrimidine nucleoside.
3. The method of claim 1 , wherein the nucleoside is a purine nucleoside.
4. The method of claim 1 wherein the β-D-2′-methyl-ribofuranosyl nucleoside is administered in combination or alternation with a second anti-flavivirus or anti-pestivirus agent.
5. The method of claim 4 , wherein the second anti-flavivirus or anti-pestivirus agent is selected from the group consisting of interferon, ribavirin, a protease inhibitor, a thiazolidine derivative, a polymerase inhibitor, and a helicase inhibitor.
6. The method of claim 5 , wherein the second anti-flavivirus or anti-pestivirus agent is interferon.
7. The method of claim 5 , wherein the second anti-flavivirus or anti-pestivirus agent is ribavirin.
8. The method of claim 1 , wherein the compound is in the form of a dosage unit.
9. The method of claim 8 , wherein the dosage unit contains 50 to 1000 mg of the β-D-2′methyl-ribofuranosyl nucleoside.
10. The method of claim 8 , wherein said dosage unit is a tablet or capsule.
11. The method of claim 1 , wherein the host is a human.
12. The method of claim 1 , wherein the β-D-2′-methyl-ribofuranosyl nucleoside is in substantially pure form.
13. The method of claim 12 , wherein the β-D-2′-methyl-ribofuranosyl nucleoside is at least 90% by weight of the β-D-isomer.
14. The method of claim 12 , wherein the β-D-2′-methyl-ribofuranosyl nucleoside is at least 95% by weight of the β-D-isomer.
15. The method of claim 1 , wherein the flavivirus or pestivirus is a Dengue virus.
16. The method of claim 1 , wherein the flavivirus or pestivirus is a West Nile virus.
17. The method of claim 1 , wherein the flavivirus or pestivirus is a yellow fever virus.
18. The method of claim 1 , wherein the flavivirus or pestivirus is a bovine viral diarrhea virus (BVDV).