IP Library Granted Patent US 7,816,501
Granted Patent B2
US 7,816,501 · App. 10/610,338 · Granted Oct 19, 2010

Compositions comprising a linked acceptor moiety

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Quick Facts
Patent No.
US 7,816,501
App. No.
10/610,338
Granted
Oct 19, 2010
Kind
B2
Abstract

This invention is directed to compositions comprising a linked acceptor moiety.

Claims (16)

1. A non-nucleic acid polymer bearing a linked acceptor moiety but not a linked donor moiety, wherein the non-nucleic acid polymer comprises subunits having the formula:

wherein

each J is the same or different and is selected from the group consisting of H, R 1 , OR 1 , SR 1 , NHR 1 , NR 1 2 , F, Cl, Br and I;

each K is the same or different and is selected from the group consisting of O, S, NH and NR 1 ;

each R 1 is the same or different and is an alkyl group having one to five carbon atoms which may optionally contain a heteroatom or a substituted or an unsubstituted aryl group;

each A is selected from the group consisting of a single bond, a group of the formula —(CJ 2 ) n — and a group of the formula —(CJ 2 ) s C(O)—;

each t is an integer having the value of 1 or 2;

each u is an integer having the value of 1 or 2;

each s is an integer having the value between 1 and 5; and

each L is the same or different and at least one L comprises the acceptor moiety but not the donor moiety.

2. The non-nucleic acid polymer of claim 1 , wherein

each L is independently selected from the group consisting of J, adenine, cytosine, guanine, thymine, uridine, 5-methylcytosine, 2- aminopurine, 2-amino-6-chloropurine, 2,6-diaminopurine, hypoxanthine, pseudoisocytosine, 2-thiouracil, 2-thiothymidine, other naturally occurring nucleobase analogs, other non-naturally occurring nucleobases, substituted and unsubstituted aromatic moieties, biotin, and dabcyl.

3. The non-nucleic acid polymer of claim 2 , wherein the non-nucleic acid polymer comprises a naturally occurring nucleobase attached to the aza nitrogen of N-[2-(aminoethyl)]glycine backbone through a methylene carbonyl linkage.

4. The non-nucleic acid polymer of claim 1 , wherein the acceptor moiety is dabcyl.

5. The non-nucleic acid polymer of claim 1 , wherein the acceptor moiety is a quencher moiety.

6. The non-nucleic acid polymer of claim 5 , wherein the quencher moiety is dabcyl.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 12, 2014
From: BOSTON PROBES, INC.
To: APPLIED BIOSYSTEMS, LLC
Reel/Frame 034627/0546 →
LIEN RELEASE Recorded Apr 8, 2013
From: BANK OF AMERICA, N.A.
To: BOSTON PROBES, INC.
Reel/Frame 030174/0230 →
SECURITY AGREEMENT Recorded Dec 5, 2008
From: BOSTON PROBES, INC.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 021924/0629 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 11, 2003
From: COULL, JAMES M.; GILDEA, BRIAN D.; HYLDIG-NIELSEN, JENS J.
To: BOSTON PROBES, INC.
Reel/Frame 014188/0837 →