IP Library › Granted Patent US 7,342,114
Granted Patent B2
US 7,342,114 · App. 10/612,240 · Granted Mar 11, 2008

Podophyllotoxin derivatives

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Quick Facts
Patent No.
US 7,342,114
App. No.
10/612,240
Granted
Mar 11, 2008
Kind
B2
Abstract

4-O esters of podophyllotoxin and 4′-demethylepipodophyllotoxin are provided. The compounds are 4-O esters of an alkanoic acid or substituted alkanoic acid and podophyllotoxin and 4′-demethylepipodophyllotoxin. The compounds are useful for treating cancer.

Claims (6)

1. A compound represented by the formula:

wherein R is C(O)—(CH 2 ) m —X—R 1 , wherein m is 1, X is a covalent bond, and R 1 is optionally substituted thymin-1-yl.

2. A compound represented by the formula:

wherein R is C(O)—(CH 2 ) m —X—R 1 , wherein m is 1, X is a covalent bond, and R 1 is 5-nitrofuran-2-yl.

3. A composition of the compound of claim 1 in combination with a pharmaceutically-acceptable excipient to form a pharmaceutical composition.

4. A composition of the compound of claim 2 in combination with a pharmaceutically-acceptable excipient to form a pharmaceutical composition.

Assignments (4)
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE'S ADDRESS FROM 475 BRANNAN STREET, SUITE 200, SAN FRANCISCO, CA 94107 PREVIOUSLY RECORDED ON REEL 023180 FRAME 0332. ASSIGNOR(S) HEREBY CONFIRMS THE CORRECT ASSIGNEE'S ADDRESS TO BE 475 BRANNAN STREET, SUITE 220, SAN FRANCISCO, CA 94107. Recorded Dec 29, 2009
From: CALIFORNIA PACIFIC MEDICAL CENTER
To: SUTTER WEST BAY HOSPITALS, DBA CALIFORNIA PACIFIC MEDICAL CENTER
Reel/Frame 023715/0749 →
CHANGE OF NAME Recorded Sep 2, 2009
From: CALIFORNIA PACIFIC MEDICAL CENTER
To: SUTTER WEST BAY HOSPITALS, DBA CALIFORNIA PACIFIC MEDICAL CENTER
Reel/Frame 023180/0332 →
CONFIRMATORY LICENSE Recorded Aug 23, 2006
From: CALIFORNIA PACIFIC MEDICAL CTR. RES. INST.
To: US GOVERNMENT - SECRETARY OF THE ARMY
Reel/Frame 018158/0964 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 2, 2003
From: YANG, LI-XI
To: CALIFORNIA PACIFIC MEDICAL CENTER; CATHOLIC HEALTHCARE WEST, DBA ST. MARY'S MEDICAL CENTER OF SAN FRANCISCO
Reel/Frame 014168/0504 →