Neurotrophin production/secretion promoting agent
View Patent ↗A neurotrophin production/secretion promoting agent which comprises an azole derivative of the formula: wherein R 1 represents a halogen atom, a heterocyclic group which may optionally be substituted, a hydroxy group which may optionally be substituted, a thiol group which may optionally be substituted, or an amino group which may optionally be substituted; A represents an acyl group which may optionally be substituted, a heterocyclic group which may optionally be substituted, a hydroxy group which may optionally be substituted, or a carboxyl group which may optionally be esterified or amidated; B represents an aromatic group which may optionally be substituted; X represents oxygen atom, sulfur atom, or nitrogen atom which may optionally be substituted; and Y represents a divalent hydrocarbon group or heterocyclic group, or a salt thereof; which is useful as an agent for preventing or treating neuropathy.
1. A method for treating senile dementia of Alzheimer's disease in a mammal in need thereof, which comprises administering to said mammal an effective amount of an azole derivative of the formula:
wherein R 1 represents an imidazolyl group which may optionally be substituted; A represents (i) a phenoxy group substituted with an alkyl group which may optionally be substituted or (ii) a phenoxy group substituted with a C 1-4 alkoxy; B represents a phenyl group which may optionally be substituted; X represents oxygen atom; and Y represents a divalent hydrocarbon group, or a salt thereof.
2. A method according to claim 1 , wherein A is a phenoxy group substituted with an alkyl group which may optionally be substituted.
3. A method according to claim 1 , wherein Y is a divalent aliphatic hydrocarbon group.
4. A method according to claim 1 , wherein the azole derivative is 4-(4-chlorophenyl)-5-[3-(2-methoxyphenoxy)propyl]-2-(2-methyl-1-imidazolyl)oxazole, 4-(4-chlorophenyl)-5-[3-(3-methoxyphenoxy)propyl]-2-(2-methyl-1-imidazolyl)oxazole, 4-(4-chlorophenyl)-5-[3-(4-methoxyphenoxy)propyl]-2-(2-methyl-1-imidazolyl)oxazole, or 4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-[3-(2-methylphenoxy)propyl]oxazole.
5. A method according to claim 1 , wherein the azole derivative is of the formula:
wherein R 1 represents an imidazolyl group which may optionally be substituted; A b represents an phenoxy group which is substituted by an alkyl group; B represents a phenyl group which may optionally be substituted; and Y represents a divalent hydrocarbon group, or a salt thereof.
6. A method according to claim 5 , wherein R 1 is an imidazolyl group which may optionally be substituted by a C 1-10 alkyl.
7. A method according to claim 5 , wherein B is a phenyl group which may optionally be substituted by halogens.
8. A method according to claim 5 , wherein Y is a divalent aliphatic hydrocarbon group.
9. A method according to claim 8 , wherein Y is a divalent C 1-4 aliphatic hydrocarbon group.
10. A method according to claim 5 , wherein the azole derivative is 4-(4-Chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-[3-(2-methylphenoxy)propyl]oxazole or a salt thereof.
11. A method according to claim 5 , wherein the azole derivative is 4-(4-Chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-[3-(3-methylphenoxy)propyl]oxazole or a salt thereof.