Antibiotics AW998A, AW998B, AW998C and AW998D
View Patent ↗This invention relates to antibiotics selected from the group AW998A, AW998B, AW998C and AW998D derived from the microorganism Streptomyces designated LL-AW998, which are useful as antibacterial agents.
1. The compound AW998A which has the structure:
2. The compound AW998B which has the structure:
3. The compound AW998C which has the structure:
4. The compound AW998D which has the structure:
5. A method of treating a warm-blooded animal affected by bacterial infections, which method comprises administering to said warm-blooded animal in need thereof an effective amount of a compound selected from the group AW998A, AW998B, AW998C and AW998D or combinations thereof.
6. A pharmaceutical composition comprising an effective amount of a compound selected from the group AW998A, AW998B, AW998C and AW998D or combinations thereof together with one or more pharmaceutically acceptable carriers.
7. A process for the preparation of a compound selected from the group AW998A, AW998B, AW998C and AW998D or combinations thereof which comprises cultivating Streptomyces designated LL-AW998 under aerobic conditions, in a sterile liquid medium containing assimilable sources of carbon, nitrogen and inorganic anion and cation salts, until substantial antibiotic activity is imparted to said medium by the production of a compound selected from the group AW998A, AW998B, AW998C and AW998D, or combination thereof, recovering and isolating compounds selected from the group AW998A, AW998B, AW998C and AW998D or combinations thereof.
8. A disinfectant composition comprising an effective amount of a compound selected from the group AW998A, AW998B, AW998C and AW998D or combinations thereof together with one or more acceptable disinfectant carriers.
9. A process according to claim 7 wherein the assimilable sources of carbon, nitrogen and inorganic anion and cation salts are Soy Flour 1.25%, N-Z Amine, (Sheffield Type A) 0.25%, Dextrose 1.25%, CaCO 3 0.1%, and NH 4 Cl 0.15%.