IP Library Granted Patent US 7,680,315
Granted Patent B2
US 7,680,315 · App. 10/622,978 · Granted Mar 16, 2010

Facilitating computer-aided detection, comparison, or display of medical images

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Quick Facts
Patent No.
US 7,680,315
App. No.
10/622,978
Granted
Mar 16, 2010
Kind
B2
Abstract

The present invention is methods for processing medical images so as to remove certain effects of the physical characteristics of the object being imaged and/or of the apparatus used to form the images. The invention further provides for the formation of a standardized image from the processed image and for the use of the standardized image or the processed image in the training of computer-aided detection/diagnosis algorithms. These algorithms may then be used to detect abnormalities in other standardized or processed images derived from any of a variety of image acquisition systems.

Claims (11)

1. A method for processing mammographic images comprising the steps of:

forming in a first mammography system a digital or digitized mammogram of a breast along with images of first and second reference materials having thicknesses that range from 0 to the thickness of the breast, one reference material having an attenuation constant that is approximately the same as that of fat and the other having an attenuation constant that is approximately the same as that of glandular tissue;

using exposure information in the images of the first and second reference materials to process the digital or digitized mammogram system to transform the digital or digitized mammogram into a first processed image whereby substantially all effects related to the physical characteristics of the first mammography system and its operating parameters and the effect of fat content in the breast being imaged are removed;

transforming the first processed image into a standard-form mammogram having pixel values that would have been obtained by a standard-form mammography system having a first standard x-ray voltage parameter and a first standard exposure parameter; and

storing said standard-form mammogram

whereby visual comparison of mammograms taken by different mammography systems is facilitated by comparing standard-form mammograms derived from mammograms taken by the different mammography systems.

2. The method of claim 1 wherein the processing removes distinguishing effects of both of the following operating parameters of the mammography system, wherein the distinguishing effects are related to at least one of:

x-ray energy;

exposure.

3. The method of claim 1 wherein the standard x-ray voltage parameter is in the range 25-28 kVp.

4. The method of claim 1 wherein the standard exposure is in the range of 20-200 milli-Ampere-seconds.

Assignments (12)
RELEASE OF SECURITY INTEREST Recorded Apr 28, 2026
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: HOLOGIC, INC., ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO DIRECT RADIOGRAPHY CORP.; CYTYC CORPORATION, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO BIOLUCENT, LLC; CYTYC SURGICAL PRODUCTS, LLC, AS SUCCESSOR-BY-CONVERSION TO CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; GEN-PROBE INCORPORATED, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.
Reel/Frame 075566/0039 →
CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT PATENT NO. 8081301 PREVIOUSLY RECORDED AT REEL: 035820 FRAME: 0239. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY INTEREST RELEASE. Recorded Nov 9, 2017
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 044727/0529 →
CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT PATENT NO. 8081301 PREVIOUSLY RECORDED AT REEL: 028810 FRAME: 0745. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY AGREEMENT. Recorded Nov 9, 2017
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
To: GOLDMAN SACHS BANK USA
Reel/Frame 044432/0565 →
SECURITY AGREEMENT Recorded Aug 7, 2015
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; DIRECT RADIOGRAPHY CORP.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 036307/0199 →
SECURITY INTEREST RELEASE REEL/FRAME 028810/0745 Recorded Jun 4, 2015
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 035820/0239 →
SECURITY AGREEMENT Recorded Aug 1, 2012
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
To: GOLDMAN SACHS BANK USA
Reel/Frame 028810/0745 →
TERMINATION OF PATENT SECURITY AGREEMENTS AND RELEASE OF SECURITY INTERESTS Recorded Aug 25, 2010
From: GOLDMAN SACHS CREDIT PARTNERS, L.P., AS COLLATERAL AGENT
To: HOLOGIC, INC.; R2 TECHNOLOGY, INC.; SUROS SURGICAL SYSTEMS, INC.; BIOLUCENT, LLC; DIRECT RADIOGRAPHY CORP.; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS LIMITED PARTNERSHIP; CYTYC SURGICAL PRODUCTS II LIMITED PARTNERSHIP; CYTYC SURGICAL PRODUCTS III, INC.; CYTYC PRENATAL PRODUCTS CORP.; THIRD WAVE TECHNOLOGIES, INC.
Reel/Frame 024944/0315 →
21ST SUPPLEMENT TO PATENT SECURITY AGREEMENT Recorded Mar 29, 2010
From: HOLOGIC, INC.
To: GOLDMAN SACHS CREDIT PARTNERS L.P., AS COLLATERAL AGENT
Reel/Frame 024151/0435 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 8, 2009
From: R2 TECHNOLOGY, INC.
To: HOLOGIC, INC.
Reel/Frame 023620/0362 →
PATENT SECURITY AGREEMENT Recorded Jul 29, 2008
From: R2 TECHNOLOGY, INC.
To: GOLDMAN SACHS CREDIT PARTNERS L.P., AS COLLATERAL AGENT
Reel/Frame 021301/0838 →
PATENT SECURITY AGREEMENT Recorded Oct 26, 2007
From: R2 TECHNOLOGY, INC.
To: GOLDMAN SACHS CREDIT PARTNERS L.P.
Reel/Frame 020024/0231 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 14, 2005
From: ROEHRIG, JIMMY R.; MARSHALL, JULIAN
To: R2 TECHNOLOGY, INC.
Reel/Frame 017235/0414 →